Anesthetics, Intravenous

Publication Title: 
The Annals of Otology, Rhinology, and Laryngology

Today cochlear implantation is a widely used means of treatment in deafness and severe hearing disorders in adults, children, and infants. Postoperative fitting of the externally worn speech processor is very important for successful use of the cochlear implant. However, especially in infants and young children, this fitting process can be difficult because of limited communication capabilities.

Author(s): 
Schultz, Arthur
Berger, Frank Andreas
Weber, Benno Paul
Grouven, Ulrich
Niclaus, Oliver
Lüllwitz, Ekkehard
Schultz, Barbara
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: This retrospective study describes the performance of the Patient State Index (PSI), under standard clinical practice conditions. The PSI is comprised of quantitative features of the EEG (QEEG) that display clear differences between hypnotic states, but consistency across anaesthetic agents within the state. METHODS: The PSI was constructed from a systematic investigation of a database containing QEEG extracted from the analyses of continuous 19 channel EEG recordings obtained in 176 surgical patients. Induction was accomplished with etomidate, propofol, or thiopental.

Author(s): 
Prichep, L. S.
Gugino, L. D.
John, E. R.
Chabot, R. J.
Howard, B.
Merkin, H.
Tom, M. L.
Wolter, S.
Rausch, L.
Kox, W. J.
Publication Title: 
Anesthesia and Analgesia

In this double-blinded randomized study, we sought to confirm that patients undergoing general anesthesia who were exposed to a hemispheric synchronization (Hemi-Sync) musical recording during surgery had a smaller analgesia requirement, as was suggested in a previous study. Bispectral index monitoring was used to adjust depth of hypnosis, and hemodynamic variables were used to determine analgesia administration. Consented patients underwent either laparoscopic bariatric or one-level lumbar disk surgery.

Author(s): 
Lewis, Ariane K.
Osborn, Irene P.
Roth, Ram
Publication Title: 
Der Anaesthesist

INTRODUCTION: We investigated the relationship between bispectral index (BIS, A-2000, Aspect Medical Systems, USA) and end-tidal desflurane concentrations below 1 MAC which is especially the range of interest if desflurane is combined with remifentanil for fast-track anaesthesia. METHODS: With institutional review board approval and written informed consent we investigated 50 adult ASA I-III patients scheduled for minor orthopaedic surgical procedures.

Author(s): 
Wrobel, M.
Kreuer, S.
Wilhelm, W.
Publication Title: 
Die Pharmazie

Propofol whole blood and plasma concentrations at offset of hypnosis in eighteen patients were inversely related to patient age and body fat. The relationship between propofol concentrations and body fat is derived from the relationship between age and body fat and age was the single independent predictor of concentrations at offset of propofol hypnosis.

Author(s): 
O'Halloran, P. L.
Hosseini-Yeganeh, M.
McBride, L. J.
Ramzan, I.
Publication Title: 
Revue Belge De Médecine Dentaire

The article describes the different ways of dealing with dental fear. First the importance of preventive dentistry is pointed out. Subsequently the potential of behaviour therapy for both children and adults is discussed. Relaxation therapy and hypnosis are considered next. From the pharmacological point of view the indications and use of oral and intravenous sedation are explained. One more option to achieve sedation is nitrous oxide inhalation. As a last resort we have general anaesthesia. Indications and procedures are outlined.

Author(s): 
Vinckier, Frans
Vansteenkiste, Griet
Publication Title: 
Biomedizinische Technik. Biomedical Engineering

A reliable assessment of the depth of hypnosis during sedation and general anaesthesia using the EEG is a subject of current interest. The Narcotrend Index implemented in the latest version 4.0 of the EEG monitor Narcotrend provides an automatic classification of the EEG on a scale ranging from 100 (awake) to 0 (very deep hypnosis, EEG suppression). The classification algorithms implemented in the EEG monitor Narcotrend are described.

Author(s): 
Schultz, A.
Grouven, U.
Beger, F. A.
Schultz, B.
Publication Title: 
European Journal of Anaesthesiology

BACKGROUND AND OBJECTIVE: This randomized, double-blinded, prospective study compared the effects of clonidine, esmolol or alfentanil on the level of hypnosis and haemodynamic responses to intravenous induction of anaesthesia and endotracheal intubation. METHODS: Forty-five patients scheduled for elective surgery were allotted to one of three groups. They were given either alfentanil 3 microg kg(-1) min(-1) (n = 15); esmolol 1 mg kg(-1) min(-1) (n = 16) or clonidine 3 microg kg(-1) (n = 14) as a 10 min infusion.

Author(s): 
Fernandez-Galinski, S.
Bermejo, S.
Mansilla, R.
Pol, O.
Puig, M. M.
Publication Title: 
Anaesthesia

Target-controlled infusion systems have been shown to result in the administration of larger doses of propofol, which may result in delayed emergence and recovery from anaesthesia. The aim of this study was to investigate if this was due to a difference in the depth of hypnosis (using the bispectral index monitoring) between the manual and target controlled systems of administration. Fifty unpremedicated patients undergoing elective surgery were randomly allocated to have their anaesthesia maintained with manual or target-controlled propofol infusion schemes.

Author(s): 
Breslin, D. S.
Mirakhur, R. K.
Reid, J. E.
Kyle, A.
Publication Title: 
European Journal of Pharmacology

Different effects of moderate to high doses of gamma-hydroxybutyric acid, including sedation/hypnosis, have been found to be blocked by gamma-aminobutyric acidB (GABAB) receptor antagonists. The present study investigated whether the protective effect of GABAB receptor antagonists extends also to gamma-hydroxybutyric acid-induced mortality. To this aim, the present study investigated the effect of the GABAB receptor antagonist, (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 100 mg/kg, ip), on mortality induced by gamma-hydroxybutyric acid (1-6 g/kg, ip) in DBA mice.

Author(s): 
Carai, Mauro A. M.
Colombo, Giancarlo
Gessa, Gian Luigi

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