Anesthetics, Intravenous

Publication Title: 
Anesthesia and Analgesia

In this study we compared the effects of propofol, small-dose isoflurane, and nitrous oxide (N(2)O) on cortical somatosensory evoked potentials (SSEP) and bispectral index (BIS) monitoring in adolescents undergoing spinal fusion. Twelve patients received the following anesthetic maintenance combinations in a randomly determined order: treatment #1: isoflurane 0.4% + N(2)O 70% + O(2) 30%; treatment #2: isoflurane 0.6% + N(2)O 70% + O(2) 30%; treatment #3: isoflurane 0.6% + air + O(2) 30%; treatment #4: propofol 120 microg . kg(-1) . min(-1) + air + O(2) 30%.

Author(s): 
Clapcich, Anthony J.
Emerson, Ronald G.
Roye, David P.
Xie, Hui
Gallo, Edward J.
Dowling, Kathy C.
Ramnath, Brian
Heyer, Eric J.
Publication Title: 
Anesthesiology

BACKGROUND: The Narcotrend index (MonitorTechnik, Bad Bramstedt, Germany) is a dimensionless number between 0 and 100 that is calculated from the electroencephalogram and inversely correlates with depth of hypnosis. The current study evaluates the capability of the Narcotrend to separate awareness from unconsciousness at the transition between these levels. METHODS: Electroencephalographic recordings of 40 unpremedicated patients undergoing elective surgery were analyzed. Patients were randomly assigned to receive (1) sevoflurane-remifentanil (</= 0.1 microg . kg .

Author(s): 
Schneider, Gerhard
Kochs, Eberhard F.
Horn, Bettina
Kreuzer, Matthias
Ningler, Michael
Publication Title: 
Anesthesia and Analgesia

The growing interest in combining local and general anesthesia has led to studies investigating possible interactions between general anesthesia and local anesthetics administered via spinal, epidural, IV, or IM routes. However, no study has evaluated the effect of local anesthetics on all three components of balanced anesthesia, i.e., hypnosis, analgesia, and muscle relaxation.

Author(s): 
Agarwal, Anil
Pandey, Ravindra
Dhiraaj, Sanjay
Singh, Prabhat K.
Raza, Mehdi
Pandey, Chandra K.
Gupta, Devendra
Choudhury, Arindam
Singh, Uttam
Publication Title: 
Critical Reviews in Neurobiology

Neurosteroids--i.e., steroid produced in brain ex novo or through metabolism of precursors--affect neuronal and brain functions through genomic and nongenomic mechanisms, depending on their molecular structure. Among neurosteroids, 3alpha-hydroxylated, 5alpha-reduced metabolites of progesterone (3alpha-hydroxy,5alpha-pregnan-20one/3alpha,5alpha-THP) and deoxycorticosterone (3alpha,21-dihydroxy,5alpha-pregnan-20one/3alpha,5alpha-THDOC) are positive allosteric modulators of gamma-aminobutyric acid (GABA) action at GABAA receptors.

Author(s): 
Barbaccia, Maria Luisa
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

General anesthetics are among the most widely used and important therapeutic agents. The molecular targets mediating different endpoints of the anesthetic state in vivo are currently largely unknown. The analysis of mice carrying point mutations in neurotransmitter receptor subunits is a powerful tool to assess the contribution of the respective receptor subtype to the pharmacological actions of clinically used general anesthetics.

Author(s): 
Zeller, Anja
Arras, Margarete
Lazaris, Anelise
Jurd, Rachel
Rudolph, Uwe
Publication Title: 
Neuroscience Letters

Propofol (2,6-diisopropylphenol) is a short-acting intravenous anesthetic. Propofol is known to impair maintenance of long-term potentiation (LTP) in synaptic responses from Schaffer collateral-commissural (SC) pathway to CA1 pyramidal cells in the hippocampus, but the threshold concentration of propofol needed to elicit this action is unknown. The actions of propofol in vivo (e.g., amnesia, sedation, hypnosis and immobility) depend on its concentration, and thus it is necessary to determine the concentration required to impair CA1 LTP in order to assess the impact of impairment in vivo.

Author(s): 
Takamatsu, Isao
Sekiguchi, Masayuki
Wada, Keiji
Sato, Tetsuo
Ozaki, Makoto
Publication Title: 
Anesthesiology

BACKGROUND: The effects of anesthetics on airway protective reflexes have not been extensively characterized in children. The aim of this study was to compare the laryngeal reflex responses in children anesthetized with either sevoflurane or propofol under two levels of hypnosis using the Bispectral Index score (BIS). The authors hypothesized that the incidence of apnea with laryngospasm evoked by laryngeal stimulation would not differ between sevoflurane and propofol when used in equipotent doses and that laryngeal responsiveness would be diminished with increased levels of hypnosis.

Author(s): 
Oberer, Christine
von Ungern-Sternberg, Britta S.
Frei, Franz J.
Erb, Thomas O.
Publication Title: 
Journal of vascular and interventional radiology: JVIR

PURPOSE: To assess how patients' underlying anxiety affects their experience of distress, use of resources, and responsiveness toward nonpharmacologic analgesia adjunct therapies during invasive procedures.

Author(s): 
Schupp, Christine J.
Berbaum, Kevin
Berbaum, Michael
Lang, Elvira V.
Publication Title: 
European Journal of Anaesthesiology

BACKGROUND: The suggested induction dose of methohexital for electroconvulsive therapy (ECT) varies widely influencing efficacy of ECT and safety of anaesthesia. Bispectral index (BIS), a monitor of consciousness, may be useful to assure adequate hypnosis with optimized methohexital dose. METHODS: Patients with medically resistant major depression (ICD10), scheduled for multiple ECT's, were studied. Depth of anaesthesia was BIS controlled. ECT was not performed until BIS dropped below 50.

Author(s): 
Hanss, R.
Bauer, M.
Bein, B.
Goeder, R.
Buttgereit, B.
Schulz-Du Bois, A. C.
Steinfath, M.
Scholz, J.
Publication Title: 
Laboratory Animals

The aim of this study was to determine and compare the degree of hypnosis achieved during propofol or sevoflurane anaesthesia in rabbits using bispectral index (BIS), and to evaluate its usefulness as a predictor of both haemodynamic changes during anaesthesia and recovery times. Twenty adult male New Zealand White rabbits, average weight 4.4 +/- 0.4 kg, were used for this study. Animals were randomly allocated to one of two groups with 10 rabbits/group. An electroencephalographic recording was obtained from each conscious rabbit prior to drug administration.

Author(s): 
Martín-Cancho, M. F.
Lima, J. R.
Luis, L.
Crisóstomo, V.
Carrasco-Jiménez, M. S.
Usón-Gargallo, J.

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