Angelica sinensis

Publication Title: 
The Journal of Nutrition

Despite recent advances in antibiotic therapy and intensive care, sepsis remains a widespread problem in critically ill patients. The high mortality from sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., tumor necrosis factor, interleukin-1, and interferon-gamma) and late [e.g., high mobility group box 1 protein (HMGB1)] proinflammatory cytokines. Our discovery of HMGB1 as a late mediator of lethal systemic inflammation has initiated a new field of investigation for the development of experimental therapeutics.

Author(s): 
Wang, Haichao
Li, Wei
Li, Jianhua
Rendon-Mitchell, Beatriz
Ochani, Mahendar
Ashok, Mala
Yang, Lihong
Yang, Huan
Tracey, Kevin J.
Wang, Ping
Sama, Andrew E.
Publication Title: 
Journal of Natural Products

Monomeric phthalides such as Z-ligustilide (1) and Z-butylidenephthalide (2) are major constituents of medicinal plants of the Apiaceae family. While 1 has been associated with a variety of observed biological effects, it is also known for its instability and rapid chemical degradation. For the purpose of isolating pure 1 and 2, a gentle and rapid two-step countercurrent isolation procedure was developed.

Author(s): 
Schinkovitz, Andreas
Pro, Samuel M.
Main, Matthew
Chen, Shao-Nong
Jaki, Birgit U.
Lankin, David C.
Pauli, Guido F.
Publication Title: 
Chemical Research in Toxicology

The roots of Angelica sinensis (Oliv.) Diels (Dang Gui; Apiaceae) have a long history in traditional Chinese medicine as a remedy for women's disorders and are often called "lady's ginseng". Currently, extracts of A. sinensis are commonly included in numerous dietary supplements used for women's health and as antiaging products. In the present study, we examined the potential chemopreventive activity of A. sinensis extracts by measuring the relative ability to induce the detoxification enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1).

Author(s): 
Dietz, Birgit M.
Liu, Dongting
Hagos, Ghenet K.
Yao, Ping
Schinkovitz, Andreas
Pro, Samuel M.
Deng, Shixin
Farnsworth, Norman R.
Pauli, Guido F.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Qidantongmai (QDTM) is a Traditional Chinese Medicine (TCM) preparation that has long been used in folk medicine for the treatment of cardiovascular diseases. However, the underlying mechanisms are poorly understood. The present study was designed to determine the effects of QDTM on endothelial cells under hypoxic conditions both in vitro and in vivo. Primary human umbilical vein endothelial cells (HUVECs) were isolated, pretreated with QDTM medicated serum or saline control, and then cultured under hypoxia (2% oxygen) for 24 h.

Author(s): 
Wang, Bing
Wang, Wen
Li, Feng
Wang, Zongren
Ma, Jing
Zhao, Gang
Publication Title: 
Sheng Li Xue Bao: [Acta Physiologica Sinica]

The aim of this article was to examine the protective effect of Chinese traditional medicine Angelica on human umbilical vein endothelial cells (HUVECs, ECV(304)) from injury induced by hyperlipidemic serum (HLS) and to study the underlying mechanisms. Microstructures of HUVECs were observed by a scanning electron microscope. Spectrophotometer and immunocytochemical methods were used to detect the content of NO in the suspension and expression of ICAM-1, TGFbeta(1), bFGF on the cell surface, respectively.

Author(s): 
Wang, B. H.
Ouyang, J. P.
Liu, Y. M.
Wei, L.
Yang, J. W.
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: In this study, we have examined the antitumor effects of chloroform extract of Angelica sinensis (AS-C), a traditional Chinese medicine, on glioblastoma multiforme (GBM) brain tumors in vitro and in vivo. EXPERIMENTAL DESIGN: In vitro, GBM cells were treated with AS-C, and the cell proliferation, changes in distributions of cell cycle, and apoptosis were determined. In vivo, human DBTRG-05MG and rat RG2 GBM tumor cells were injected s.c. or i.c. and were treated with AS-C.

Author(s): 
Tsai, Nu-Man
Lin, Shinn-Zong
Lee, Chau-Chin
Chen, Shee-Ping
Su, Hsuan-Chi
Chang, Wen-Liang
Harn, Horng-Jyh
Publication Title: 
Chemical Research in Toxicology

The roots of Angelica sinensis (Oliv.) Diels (Dang Gui; Apiaceae) have a long history in traditional Chinese medicine as a remedy for women's disorders and are often called "lady's ginseng". Currently, extracts of A. sinensis are commonly included in numerous dietary supplements used for women's health and as antiaging products. In the present study, we examined the potential chemopreventive activity of A. sinensis extracts by measuring the relative ability to induce the detoxification enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1).

Author(s): 
Dietz, Birgit M.
Liu, Dongting
Hagos, Ghenet K.
Yao, Ping
Schinkovitz, Andreas
Pro, Samuel M.
Deng, Shixin
Farnsworth, Norman R.
Pauli, Guido F.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Dozens of Traditional Chinese Medicine (TCM) formulas have been used for promotion of "blood production" for centuries, and we are interested in developing novel thrombopoietic medicines from these TCMs. Our previous studies have demonstrated the hematopoietic effects of DangGui BuXue Tong (DBT), a formula composed of Radix Angelicae Sinensis and Radix Astragali in animal and cellular models.

Author(s): 
Liu, Chang
Li, Jianqin
Meng, Fan Yi
Liang, Simon X.
Deng, Ruixia
Li, Chi Kong
Pong, N. H.
Lau, Ching Po
Cheng, Sau Wan
Ye, Jie Yu
Chen, Jian L.
Yang, S. T.
Yan, Haixia
Chen, Shilin
Chong, Beng H.
Yang, Mo
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype accounting for approximately 3 to 7% of cases each year. Despite its rarity among the various stroke types, SAH is still responsible for approximately 25% of all stroke fatalities. Although various preventative and therapeutic interventions have been explored for potential neuroprotection after SAH, a considerable percentage of patients still experience serious neurologic and/or cognitive impairments as a result of the primary hemorrhage and/or secondary brain damage that occurs.

Author(s): 
Chen, Di
Tang, Jiping
Khatibi, Nikan H.
Zhu, Mei
Li, Yingbo
Wang, Chengyuan
Jiang, Rong
Tu, Liu
Wang, Shali
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Qidantongmai (QDTM) is a Traditional Chinese Medicine (TCM) preparation that has long been used in folk medicine for the treatment of cardiovascular diseases. However, the underlying mechanisms are poorly understood. The present study was designed to determine the effects of QDTM on endothelial cells under hypoxic conditions both in vitro and in vivo. Primary human umbilical vein endothelial cells (HUVECs) were isolated, pretreated with QDTM medicated serum or saline control, and then cultured under hypoxia (2% oxygen) for 24 h.

Author(s): 
Wang, Bing
Wang, Wen
Li, Feng
Wang, Zongren
Ma, Jing
Zhao, Gang

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