The Journal of Pharmacology and Experimental Therapeutics
The effect of methaqualone on the induction of hepatic enzymes was evaluated in rats and compared with that of phenobarbital by measuring effects on hexobarbital and methaqualone hypnosis, plasma and tissue levels of methaqualone, hepatic aniline hydroxylase and aminopyrine demethylase activity and warfarin-induced hypoprothrombinemia. Maximal reductions in hexobarbital hypnosis occurred 3 days after daily administration of 60 mg of methaqualone per kg per day.
Induction of hepatic propoxyphene N-demethylase and aniline hydroxylase activities resulted following repeated oral administration of 25, 50 and 100 mg d-propoxyphene hydrochloride per kg daily in the mouse over a six-day period. A significant elevation in both enzyme activities was noted after a single dose of propoxyphene (100 mg/kg). A dose-related response characterized the observed induction of each microsomal enzyme activity.
Research Communications in Chemical Pathology and Pharmacology
Three days after pretreatment of rats of both sexes with sodium selenite (2.4 mg Se/kg, ip) the duration of pentobarbital-induced hypnosis was potentiated in males but not females. Similar treatment with selenium led to a significant inhibition of ethylmorphine demethylase activity by hepatic microsomal enzymes obtained from male but not female rats. Selenium treatment did not alter the activity of aniline hydroxylase in animals of either sex.
1. Pretreatment with a Cannabis constituent, cannabichromene (CBC), i.p., had no effect on in vitro hepatic microsomal enzyme activity compared to a known inhibitor of these systems, SKF 525-A. 2. The results indicate that the previously reported CBC potentiation of CNS depressant-induced hypnosis is not mediated by the hepatic microsomal enzyme system.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases
In this paper, the effect of Schistosoma japonicum infection on liver drug-metabolizing enzymes of mice was studied. The prolongation of hypnosis duration of sodium pentobarbital in vivo and the inhibition of liver aniline hydroxylase (AH), aminopyrine N-demethylase (APD) as well as cytochrome P-450 (Cyt P-450) in vitro were observed in mice infected with 20, 40 and 60 cercariae of S. japonicum after 6 weeks.