Publication Title: 
Autonomic Neuroscience: Basic & Clinical

Enkephalinergic neurons in the rostral ventrolateral medulla (rVLM), an important presympathetic region in the brainstem, are activated by 30 min of low frequency (2 Hz) electroacupuncture (EA) at acupoints P5-P6, which overlie the median nerves. To more closely model the clinical application of acupuncture, we administered EA for 30 min twice over a 72 h period to unsedated conscious rats to examine its prolonged action. We hypothesized that repetitive EA would increase preproenkephalin mRNA and met-enkephalin in the rVLM of unsedated conscious rats.

Li, Min
Tjen-A-Looi, Stephanie C.
Guo, Zhi-Ling
Longhurst, John C.
Publication Title: 
PloS One

BACKGROUND: Our previous research and other studies with radiotracers showed evidence of a centripetal drainage pathway, separate from blood or lymphatic vessels, that can be visualized when a small amount of low molecular weight tracer is injected subcutaneously into a given region on skin of humans. In order to further characterize this interesting biological phenomenon, animal experiments are designed to elucidate histological and physiologic characteristics of these visualized pathways.

Li, Hong-yi
Chen, Min
Yang, Jie-fu
Yang, Chong-qing
Xu, Liang
Wang, Fang
Tong, Jia-bin
Lv, You
Suonan, Caidan
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To observe the effects of electro-acupuncture (EA) at related Jing-well Points (HT 9, PC 9, KI 1 and LU 11) in rats with vascular dementia (VD) and discuss the relative mechanism. METHODS: A randomized controlled animal experiment was designed. A total of 104 rats were involved in the present study and divided randomly into 4 groups: sham-operation group, model group, Jing-well Points group, and medication group. The VD model was established according to the modified 4-vessel occlusion (4-VO) method.

He, Feng
Publication Title: 
PloS One

BACKGROUND: Electroacupuncture (EA) has been widely used to alleviate diverse pains. Accumulated clinical experiences and experimental observations indicated that significant differences exist in sensitivity to EA analgesia for individuals of patients and model animals. However, the molecular mechanism accounting for this difference remains obscure.

Wang, Ke
Zhang, Rong
Xiang, Xiaohui
He, Fei
Lin, Libo
Ping, Xingjie
Yu, Lei
Han, Jisheng
Zhao, Guoping
Zhang, Qinghua
Cui, Cailian
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the effects of electroacupuncture (EA) at Neiguan (PC6) and Xinshu (BL15) on the nerve electrical activity in spinal dorsal root and norepinephrine (NE) and dopamine (DA) concentrations in the paraventricular nucleus of the hypothalamus in rats with acute myocardial ischemia (AMI). METHODS: A total of 100 male Sprague-Dawley rats were randomly divided into sham-operation, model, EA at PC6, EA at BL15 and EA at both PC6 and BL15 groups with 20 rats in each group. The nerve electrical activity in spinal dorsal roots was recorded by bipolar electrodes.

Li, Meng
Hu, Ling
Cai, Rong-lin
Wu, Zi-jian
Wang, Ke-ming
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The improvement of axonal regeneration is a major objective in the treatment of peripheral nerve injuries. The aim of this study was to evaluate the effects of electro-acupuncture on the functional recovery of sensorimotor responses following left sciatic nerve crush in mice. METHODS: Sciatic nerve crush was performed on seven week old female mice. Following the injury, the control group was untreated while the experimental group received an electro-acupuncture application to the injured limb under isoflurane anesthesia at acupoints GB 30 and GB 34.

Hoang, Ngoc Son
Sar, Chamroeun
Valmier, Jean
Sieso, Victor
Scamps, Frédérique
Publication Title: 
PloS One

Previous animal and clinical studies have shown that acupuncture is an effective alternative treatment in the management of hypertension, but the mechanism is unclear. This study investigated the proteomic response in the nervous system to treatment at the Taichong (LR3) acupoint in spontaneously hypertensive rats (SHRs). Unanesthetized rats were subject to 5-min daily acupuncture treatment for 7 days. Blood pressure was monitored over 7 days. After euthanasia on the 7(th) day, rat medullas were dissected, homogenized, and subject to 2D gel electrophoresis and MALDI-TOF analysis.

Lai, Xinsheng
Wang, Jiayou
Nabar, Neel R.
Pan, Sanqiang
Tang, Chunzhi
Huang, Yong
Hao, Mufeng
Yang, Zhonghua
Ma, Chunmei
Zhang, Jin
Chew, Helen
He, Zhenquan
Yang, Junjun
Su, Baogui
Zhang, Jian
Liang, Jun
Sneed, Kevin B.
Zhou, Shu-Feng
Publication Title: 
BMC neuroscience

BACKGROUND: Electroacupuncture (EA) pretreatment can induce the tolerance against focal cerebral ischemia. However, the underlying mechanisms have not been fully understood. Emerging evidences suggest that canonical Notch signaling may be involved in ischemic brain injury. In the present study, we tested the hypothesis that EA pretreatment-induced tolerance against focal cerebral ischemia is mediated by Notch signaling.

Zhao, Yu
Chen, Xiyao
Ma, Lei
Zuo, Zhiyi
Zhu, Zhenghua
Zhu, Xiaoling
Wang, Qiang
He, Ertao
Xiong, Lize
Pei, Jianming
Xu, Lixian
Hou, Lihong
Chen, Shaoyang
Publication Title: 

OBJECTIVE: The purpose of this study was to determine the effects of electroacupuncture (EA) ST36 on food intake and body weight in obese prone (OP) rats compared to obese resistant (OR) strain on a high fat diet. The influences of EA on mRNA levels of pro-opiomelanocortin (POMC), transient receptor potential vanilloid type-1 (TRPV1), and neuronal nitric oxide synthase (nNOS) were also examined in the medulla regions and ST36 skin tissue. METHODS: Advanced EA ST36 was conducted in two sessions of 20 min separated by an 80 min interval for 7 days.

Ji, Bo
Hu, Jay
Ma, Shengxing
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Orexin A (OXA, hypocretin/hcrt 1) is a newly discovered potential analgesic substance. However, whether OXA is involved in acupuncture analgesia remains unknown. The present study was designed to investigate the involvement of spinal OXA in electroacupuncture (EA) analgesia. METHODS: A modified rat model of post-laparotomy pain was adopted and evaluated. Von Frey filaments were used to measure mechanical allodynia of the hind paw and abdomen. EA at 2/15 Hz or 2/100 Hz was performed once on the bilateral ST36 and SP6 for 30 min perioperatively.

Feng, Xiao-Ming
Mi, Wen-Li
Xia, Fang
Mao-Ying, Qi-Liang
Jiang, Jian-Wei
Xiao, Sheng
Wang, Zhi-Fu
Wang, Yan-Qing
Wu, Gen-Cheng


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