Publication Title: 
PloS One

Administration of cocaine increases locomotor activity by enhancing dopamine transmission. To explore the peripheral mechanisms underlying acupuncture treatment for drug addiction, we developed a novel mechanical acupuncture instrument (MAI) for objective mechanical stimulation. The aim of this study was to evaluate whether acupuncture inhibition of cocaine-induced locomotor activity is mediated through specific peripheral nerves, the afferents from superficial or deep tissues, or specific groups of nerve fibers.

Kim, Seol Ah
Lee, Bong Hyo
Bae, Jong Han
Kim, Kwang Joong
Steffensen, Scott C.
Ryu, Yeon-Hee
Leem, Joong Woo
Yang, Chae Ha
Kim, Hee Young
Publication Title: 
PloS One

Low dose methotrexate is the cornerstone for the treatment of rheumatoid arthritis. One of its major drawbacks is hepatotoxicity, resulting in poor compliance of therapy. Dissatisfied arthritis patients are likely to seek the option of complementary and alternative medicine such as bee venom. The combination of natural products with modern medicine poses the possibility of potential interaction between the two groups and needs investigation.

Darwish, Samar F.
El-Bakly, Wesam M.
Arafa, Hossam M.
El-Demerdash, Ebtehal
Publication Title: 

In the last decade, preclinical investigations of electroacupuncture mechanisms on persistent tissue injury (inflammatory), nerve injury (neuropathic), cancer, and visceral pain have increased. These studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2 to 10 Hz than at 100 Hz.

Zhang, Ruixin
Lao, Lixing
Ren, Ke
Berman, Brian M.
Publication Title: 
PloS One

Hippocampal neurons play a critical role in learning and memory; however, the effects of environmental mechanical forces on neurite extension and associated underlying mechanisms are largely unexplored, possibly due to difficulties in maintaining central nervous system neurons. Neuron adhesion, neurite length, and mechanotransduction are mainly influenced by the extracellular matrix (ECM), which is often associated with structural scaffolding.

Chen, Wei-Hsin
Cheng, Sin-Jhong
Tzen, Jason T. C.
Cheng, Chao-Min
Lin, Yi-Wen
Publication Title: 
PloS One

Depletion of interstitial cells of Cajal (ICC) is certified in the stomach of diabetic patients. Though electroacupuncture (EA) at ST36 is an effective therapy to regulate gastric motility, the mechanisms of EA at ST36 on gastric emptying and networks of ICC remain to be elucidated. The aims of this study were to investigate the effects of EA on gastric emptying and on the alterations of ICC networks.

Chen, Yan
Xu, Juan Juan
Liu, Shi
Hou, Xiao Hua
Publication Title: 
Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia

PURPOSE: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. METHODS: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg(-1) of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg(-1) of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint.

Cassu, Renata Navarro
Melchert, Alessandra
Canoa, Jiancarlo Tortoza Bignelli
Martins, Paula Denise de Oliveira
Publication Title: 
Nature Medicine

Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals, had limited efficacy in clinical trials, in part because they targeted single cytokines and the experimental models failed to mimic clinical settings. Neuronal networks represent physiological mechanisms, selected by evolution to control inflammation, that can be exploited for the treatment of inflammatory and infectious disorders. Here, we report that sciatic nerve activation with electroacupuncture controls systemic inflammation and rescues mice from polymicrobial peritonitis.

Torres-Rosas, Rafael
Yehia, Ghassan
Peña, Geber
Mishra, Priya
del Rocio Thompson-Bonilla, Maria
Moreno-Eutimio, Mario Adán
Arriaga-Pizano, Lourdes Andrea
Isibasi, Armando
Ulloa, Luis
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture (EA) and human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied.

Yang, Zhuoxin
Chen, Pengdian
Yu, Haibo
Luo, Wenshu
Pi, Min
Wu, Yonggang
Wang, Ling
Yang, Fuxia
Gou, Yanhua
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

14-3-3 is a family of regulatory proteins highly expressed in the brain. Previous invertebrate studies have demonstrated the importance of 14-3-3 in the regulation of synaptic functions and learning and memory. However, the in vivo role of 14-3-3 in these processes has not been determined using mammalian animal models. Here, we report the behavioral and electrophysiological characterization of a new animal model of 14-3-3 proteins. These transgenic mice, considered to be a 14-3-3 functional knock-out, express a known 14-3-3 inhibitor in various brain regions of different founder lines.

Qiao, Haifa
Foote, Molly
Graham, Kourtney
Wu, Yuying
Zhou, Yi
Publication Title: 
Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan / Sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine

OBJECTIVE: To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin (POMC) and prodynorphin (PDYN) mRNA expressions and plasma beta-endorphin (beta-EP) content in rheumatoid arthritis (RA) rats, to understand the mechanism of moxibustion analgesia and its dose-effect relationship. METHODS: Twelve male Wistar rats were randomly selected from 48 male Wistar rats as a normal control group.

Zheng, Baozhu
Hu, Ling
Song, Xiaoge
Wu, Zijian
Cai, Ronglin
He, Lu
Zhang, Cheng
Yu, Qing


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