Anopheles gambiae

Publication Title: 
PLoS pathogens

A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly, there is still a paucity of effector molecules with potent anti-malaria activity whose expression does not cause detrimental effects on mosquito fitness. Our objective was to examine a wide range of antimicrobial peptides (AMPs) for their toxic effects on Plasmodium and anopheline mosquitoes.

Carter, Victoria
Underhill, Ann
Baber, Ibrahima
Sylla, Lakamy
Baby, Mounirou
Larget-Thiery, Isabelle
Zettor, AgnËs
Bourgouin, Catherine
Langel, Ulo
Faye, Ingrid
Otvos, Laszlo
Wade, John D.
Coulibaly, Mamadou B.
Traoré, Sekou F.
Tripet, Frederic
Eggleston, Paul
Hurd, Hilary
Publication Title: 
Science (New York, N.Y.)

The African continent continues to bear the greatest burden of malaria and the greatest diversity of parasites, mosquito vectors, and human victims. The evolutionary plasticity of malaria parasites and their vectors is a major obstacle to eliminating the disease. Of current concern is the recently reported emergence of resistance to the front-line drug, artemisinin, in South-East Asia in Plasmodium falciparum, which calls for preemptive surveillance of the African parasite population for genetic markers of emerging drug resistance.

Ghansah, Anita
Amenga-Etego, Lucas
Amambua-Ngwa, Alfred
Andagalu, Ben
Apinjoh, Tobias
Bouyou-Akotet, Marielle
Cornelius, Victoria
Golassa, Lemu
Andrianaranjaka, Voahangy Hanitriniaina
Ishengoma, Deus
Johnson, Kimberly
Kamau, Edwin
Maïga-Ascofaré, Oumou
Mumba, Dieudonne
Tindana, Paulina
Tshefu-Kitoto, Antoinette
Randrianarivelojosia, Milijaona
William, Yavo
Kwiatkowski, Dominic P.
Djimde, Abdoulaye A.
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