Anorexia Nervosa

Publication Title: 
Journal of the American Psychiatric Nurses Association

BACKGROUND: Anorexia nervosa is a serious psychiatric illness with limited evidenced-based treatment options. Mindfulness appears useful in many conditions, but few studies focus on its use in individuals with anorexia nervosa. OBJECTIVE: To examine and summarize studies of mindfulness in individuals with anorexia nervosa and identify areas for future research. DESIGN: An integrated review was conducted by searching health care computerized databases. RESULTS: Results were mixed among the eight studies that met inclusion criteria.

Dunne, Julie
Publication Title: 
Eating Behaviors

This systematic review critically appraises the role of complementary and alternative medicine in the treatment of those with an eating disorder. Sixteen studies were included in the review. The results of this review show that the role of complementary and alternative medicine in the treatment of those with an eating disorder is unclear and further studies should be conducted.

Fogarty, Sarah
Smith, Caroline A.
Hay, Phillipa
Publication Title: 
Medical Hypotheses

Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psychiatric disorder in which there is altered handling of signals which otherwise are useful in survival/longevity.

Spencer, R. P.
Publication Title: 
Mayo Clinic Proceedings
Nelson, Ralph A.
Publication Title: 

Vegetarianism in its various forms, is widely encountered in different societies all over the world; thus, combining nutritional, social, behavioral and psychological aspects. The prevalence of vegetarianism in the western world, as well as in Israel, is dealt with in this review. The extent of vegetarianism among young patients with eating disorders is much higher than in any other age group. Anorexia nervosa patients in Israel admit to be vegetarians in 85% (mean), as compared to 65% (mean) in other western countries.

Aloufy, Aviva
Latzer, Yael
Publication Title: 
Journal of Psychiatric Research

Proopiomelanocortin (POMC) and its derived peptides, in particular alpha-MSH, have been shown to play a crucial role in the regulation of hunger, satiety and energy homeostasis. Studies in patients with anorexia nervosa (AN) suggest an abnormal expression of appetite-regulating hormones. Hormone expression levels may be modulated by epigenetic mechanisms, which were recently shown to be implicated in the pathophysiology of eating disorders.

Ehrlich, Stefan
Weiss, Deike
Burghardt, Roland
Infante-Duarte, Carmen
Brockhaus, Simone
Muschler, Marc A.
Bleich, Stefan
Lehmkuhl, Ulrike
Frieling, Helge
Publication Title: 
Psychosomatic Medicine

OBJECTIVES: Comorbidity among eating disorders, traumatic events, and posttraumatic stress disorder (PTSD) has been reported in several studies. The main objectives of this study were to describe the nature of traumatic events experienced and to explore the relationship between PTSD and anorexia nervosa (AN) in a sample of women. METHODS: Eight hundred twenty-four participants from the National Institutes of Health-funded Genetics of Anorexia Nervosa Collaborative Study were assessed for eating disorders, PTSD, and personality characteristics.

Reyes-RodrÌguez, Mae Lynn
Von Holle, Ann
Ulman, Teresa Frances
Thornton, Laura M.
Klump, Kelly L.
Brandt, Harry
Crawford, Steve
Fichter, Manfred M.
Halmi, Katherine A.
Huber, Thomas
Johnson, Craig
Jones, Ian
Kaplan, Allan S.
Mitchell, James E.
Strober, Michael
Treasure, Janet
Woodside, D. Blake
Berrettini, Wade H.
Kaye, Walter H.
Bulik, Cynthia M.
Publication Title: 
Clinical Pharmacology and Therapeutics

Anorexia nervosa (AN) is a disease defined by inappropriate weight loss and maintenance of body weight <85% of that expected for weight and height; it is most common in adolescent women aged 15-19 years. Numerous studies have highlighted the familial aggregation of the disease, suggesting a significant genetic component to its etiology. The purpose of this review is to discuss the different fields of genetic research--both in humans and animals--that have contributed to the understanding of this complex disorder.

Clarke, T. K.
Weiss, A. R. D.
Berrettini, W. H.
Publication Title: 
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie

OBJECTIVE: Our pilot study evaluates the impact of environmental factors, such as nutrition and smoking status, on epigenetic patterns in a disease-associated gene. METHOD: We measured the effects of malnutrition and cigarette smoking on proopiomelanocortin (POMC) promoter-specific DNA methylation in female patients with and without anorexia nervosa (AN). POMC and its derived peptides (alpha melanocyte stimulating hormone and adrenocorticotropic hormone) are implicated in stress and feeding response.

Ehrlich, Stefan
Walton, Esther
Roffman, Joshua L.
Weiss, Deike
Puls, Imke
Doehler, Nico
Burghardt, Roland
Lehmkuhl, Ulrike
Hillemacher, Thomas
Muschler, Marc
Frieling, Helge
Publication Title: 
The World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry

OBJECTIVES: The one-carbon metabolism, also known as methionine-homocysteine cycle, governs the dynamics of DNA methylation, epigenetically regulating gene expression, and has been reported altered in anorexia nervosa (AN) adult patients. The aim of this study consisted in assessing whole-blood DNA methylation in adolescent AN patients, assessing its significance in relationship to clinical and hormonal variables.

Tremolizzo, L.
Conti, E.
Bomba, M.
Uccellini, O.
Rossi, M. S.
Marfone, M.
Corbetta, F.
Santarone, M. E.
Raggi, M. E.
Neri, F.
Ferrarese, C.
Nacinovich, R.


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