Anthocyanins

Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVE: To critically evaluate the evidence regarding complementary and alternative medicines (CAMs) taken orally or applied topically for the treatment of FM. METHODS: Randomized controlled trials of FM using CAMs, in comparison with other treatments or placebo, published in English up to March 2009, were eligible for inclusion. They were identified using systematic searches of bibliographic databases and manual searching of reference lists.

Author(s): 
De Silva, Vijitha
El-Metwally, Ashraf
Ernst, Edzard
Lewith, George
Macfarlane, Gary J.
Arthritis Research Campaign working group on complementary and alternative medicines
Publication Title: 
Journal of Food Science

Total phenolic content, total antioxidant activity of Myrobalan plum (Prunus cerasifera Ehrh.) and anthocyanin content in peel were analyzed in this article. In addition, ultra-performance liquid chromatography with photodiode array detection and electrospray ionization tandem mass spectrometry were used to determine anthocyanin composition of this fruit. The range of total phenolic content of the tested samples was 1.34 to 6.11 g/kg fresh weight (FW), and anthocyanin content in fruit peel of Myrobalan plum was from 1.93 to 19.86 g/kg peel.

Author(s): 
Wang, Yan
Chen, Xiaoliu
Zhang, Yanmin
Chen, Xuesen
Publication Title: 
Food Chemistry

Wild edible fruits contribute significantly to the nutritional security of mankind across the globe. However, detailed analyses of health promoting bioactive compounds and antioxidants are lacking, especially in Himalayan wild edible fruits.

Author(s): 
Bhatt, Indra D.
Rawat, Sandeep
Badhani, Amit
Rawal, Ranbeer S.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Withania somnifera, also known as ashwagandha, is an important herb in ayurvedic and indigenous medical systems. The present study was designed to evaluate the antioxidant and antibacterial activities of an 80% aqueous methanolic extract of W. somnifera roots (WSREt), fruits (WSFEt) and leaves (WSLEt). METHODS: Several assays were performed to determine the antioxidant properties of this herb including 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, ferric reducing antioxidant power (FRAP), ferrous chelation and inhibition of β-carotene bleaching.

Author(s): 
Alam, Nadia
Hossain, Monzur
Mottalib, Md Abdul
Sulaiman, Siti Amrah
Gan, Siew Hua
Khalil, Md Ibrahim
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Withania somnifera, also known as ashwagandha, is an important herb in ayurvedic and indigenous medical systems. The present study was designed to evaluate the antioxidant and antibacterial activities of an 80% aqueous methanolic extract of W. somnifera roots (WSREt), fruits (WSFEt) and leaves (WSLEt). METHODS: Several assays were performed to determine the antioxidant properties of this herb including 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, ferric reducing antioxidant power (FRAP), ferrous chelation and inhibition of β-carotene bleaching.

Author(s): 
Alam, Nadia
Hossain, Monzur
Mottalib, Md Abdul
Sulaiman, Siti Amrah
Gan, Siew Hua
Khalil, Md Ibrahim
Publication Title: 
The Journal of Investigative Dermatology

Solar UV radiation, in particular its UVB component, is the primary cause of many adverse biological effects, the most damaging of which is skin cancer. Here, we assessed the photochemopreventive effect of delphinidin, a major anthocyanidin present in many pigmented fruits and vegetables, on UVB-mediated responses in human immortalized HaCaT keratinocytes and SKH-1 hairless mouse skin. We found that pretreatment of cells with delphinidin (1-20 microM for 24 hours) protected against UVB (15-30 mJ/cm2, 24 hours)-mediated (i) decrease in cell viability and (ii) induction of apoptosis.

Author(s): 
Afaq, Farrukh
Syed, Deeba N.
Malik, Arshi
Hadi, Naghma
Sarfaraz, Sami
Kweon, Mee-Hyang
Khan, Naghma
Zaid, Mohammad Abu
Mukhtar, Hasan
Publication Title: 
Journal of Agricultural and Food Chemistry

Four wild berry species, Amelanchier alnifolia, Viburnum trilobum, Prunus virginiana, and Shepherdia argentea, all integral to the traditional subsistence diet of Native American tribal communities, were evaluated to elucidate phytochemical composition and bioactive properties related to performance and human health. Biological activity was screened using a range of bioassays that assessed the potential for these little-known dietary berries to affect diabetic microvascular complications, hyperglycemia, pro-inflammatory gene expression, and metabolic syndrome symptoms.

Author(s): 
Burns Kraft, Tristan F.
Dey, Moul
Rogers, Randy B.
Ribnicky, David M.
Gipp, David M.
Cefalu, William T.
Raskin, Ilya
Lila, Mary Ann
Publication Title: 
The American Journal of Clinical Nutrition

Metabolic syndrome describes the human condition characterized by the presence of coexisting traditional risk factors for cardiovascular disease, such as hypertension, dyslipidemia, glucose intolerance, and obesity, in addition to nontraditional cardiovascular disease risk factors, such as inflammatory processes and abnormalities of the blood coagulation system.

Author(s): 
Cefalu, William T.
Ye, Jianping
Zuberi, Aamir
Ribnicky, David M.
Raskin, Ilya
Liu, Zhijun
Wang, Zhong Q.
Brantley, Phillip J.
Howard, Luke
Lefevre, Michael
Publication Title: 
Metabolism: Clinical and Experimental

The mechanism(s) through which fruits, vegetables, and whole grains favorably affect health is not well established. Using an anthocyanin-rich grape as a model, we examined the ability of an agnostic analytical approach using gene expression microarrays to generate novel testable hypotheses regarding the mechanisms of action of potentially healthful foods and food components. C57BL/6 mice were divided into 2 groups and fed a proatherogenic diet with or without a semipurified anthocyanin extract (70% anthocyanins) incorporated at a level of 0.1 mg/mL into the drinking water.

Author(s): 
Lefevre, Michael
Wiles, Judith E.
Zhang, Xiaying
Howard, Luke R.
Gupta, Sunita
Smith, Andrea A.
Ju, Zhi Y.
DeLany, James P.
Publication Title: 
Pharmaceutical Research

PURPOSE: Results from our oral cavity chemoprevention trial demonstrated appreciable interpatient variations regarding chemopreventive efficacy of a freeze dried black raspberry (FBR) gel. We speculated these data reflected individual patient-related differences in absorption, target tissue uptake and local compound metabolism of key FBR compounds (anthocyanins). Accordingly, this study assessed the distribution of anthocyanins from the 10% (w/w) FBR gel in saliva, oral tissues and plasma.

Author(s): 
Ugalde, Carlos M.
Liu, Zhongfa
Ren, Chen
Chan, Kenneth K.
Rodrigo, Kapila A.
Ling, Yhonghua
Larsen, Peter E.
Chacon, Guillermo E.
Stoner, Gary D.
Mumper, Russell J.
Fields, Henry W.
Mallery, Susan R.

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