Anthraquinones

Publication Title: 
Physical Therapy

An increasing number of systematic reviews are available regarding nonpharmacological and nonsurgical interventions for hip osteoarthritis (OA). The objectives of this article are to identify high-quality systematic reviews on the effect of nonpharmacological and nonsurgical interventions for hip OA and to summarize available high-quality evidence for these treatment approaches. The authors identified and screened 204 reviews. Two independent reviewers using a previously pilot-tested quality assessment form assessed the full text of 58 reviews.

Author(s): 
Moe, Rikke H.
Haavardsholm, Espen A.
Christie, Anne
Jamtvedt, Gro
Dahm, Kristin Thuve
Hagen, Kåre Birger
Publication Title: 
Physical Therapy

An increasing number of systematic reviews are available regarding nonpharmacological and nonsurgical interventions for hip osteoarthritis (OA). The objectives of this article are to identify high-quality systematic reviews on the effect of nonpharmacological and nonsurgical interventions for hip OA and to summarize available high-quality evidence for these treatment approaches. The authors identified and screened 204 reviews. Two independent reviewers using a previously pilot-tested quality assessment form assessed the full text of 58 reviews.

Author(s): 
Moe, Rikke H.
Haavardsholm, Espen A.
Christie, Anne
Jamtvedt, Gro
Dahm, Kristin Thuve
Hagen, Kåre Birger
Publication Title: 
Journal of Endodontics

INTRODUCTION: Dental pulp stem cells (DPSCs) have received much attention as a promising population of stem cells in regenerative endodontics. Securing a good blood supply during regeneration is a challenging task because of the constricted apical canal opening, which allows only a limited blood supply. The aim of this study was to investigate any potential synergistic effects of dental pulp stem cells and endothelial cells (ECs) on osteo-/odontogenic and angiogenic differentiation in vitro.

Author(s): 
Dissanayaka, Waruna Lakmal
Zhan, Xuan
Zhang, Chengfei
Hargreaves, Kenneth M.
Jin, Lijian
Tong, Edith H. Y.
Publication Title: 
Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

OBJECTIVE: To isolate and elucidate the constituents from stem of Chirita longgangensis var. hongyao. METHOD: The constituents were extracted with methanol and isolated by chromatography on silica gel, Sephadex LH-20 and ODS. The structures were determined by NMR and MS spectral analysis. RESULT: Seven compounds were identified as 2-hydroxy-7-methyl-9, 10-anthraquinone (1), 2-methyl-9, 10-anthraquinone (tectoquinone) (2), ursolic acid (3), vanillic acid (4), beta-sitosteryl-D-glucoside-6'-palmitate (5), beta-sitosterol (6), daucosterol (7), respectively.

Author(s): 
Wang, Man-Yuan
Yang, Lan
Tu, You-you
Publication Title: 
The Journal of Pharmacy and Pharmacology

Senna is a well-known drug, used in the Ayurvedic and Allopathic systems of medicine, and is a treatment for constipation. The purgative action of senna and its formulations is due to the presence of sennosides A and B. An HPTLC method has been developed for the determination of individual sennosides (A, B, C, D) without any derivatization in marketed formulations (three tablet formulations, two granule formulations and one liquid formulation) and plant materials (senna leaf and pod). The methanolic solution of a sample was applied on a pre-coated silica gel G60 F254 TLC plate (E.

Author(s): 
Shah, S. A.
Ravishankara, M. N.
Nirmal, A.
Shishoo, C. J.
Rathod, I. S.
Suhagia, B. N.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Rubia cordifolia L. (Rubiaceae) is an important medicinal plant used in the Ayurvedic medicinal system. Its use as a traditional therapeutic has been related to the treatment of skin disorders and cancer. Besides its medicinal value, anthraquinones from this plant are used as natural food colourants and as natural hair dyes. Dyes derived from natural sources have emerged as important alternatives to synthetic dyes. Alizarin (1,2-dihydroxyanthraquinone) was isolated and characterized from R. cordifolia L. and evaluated for its antigenotoxic potential against a battery of mutagens viz.

Author(s): 
Kaur, Prabhjit
Chandel, Madhu
Kumar, Subodh
Kumar, Neeraj
Singh, Bikram
Kaur, Satwinderjeet
Publication Title: 
Planta Medica

Aloe is a genus of medicinal plants with a notable history of medical use. Basic research over the past couple of decades has begun to reveal the extent of Aloe's pharmaceutical potential, particularly against neoplastic disease. This review looks at Aloe, both the genus and the folk medicine, often being called informally "aloes", and delineates their chemistry and anticancer pharmacognosy. Structures of key compounds are provided, and their pharmacological activities reviewed.

Author(s): 
Harlev, Eli
Nevo, Eviatar
Lansky, Ephraim P.
Ofir, Rivka
Bishayee, Anupam
Publication Title: 
The Indian Journal of Medical Research

BACKGROUND & OBJECTIVES: Obesity is now considered as a major risk factor for the development of fatty liver diseases, cardiovascular diseases, and atherosclerosis. SoSoSo is a newly developed dietary supplement made of seven medicinal herbs. This study was aimed at examining the anti-obesity effect of SoSoSo or its active ingredient chrysophanol on the production of inflammatory cytokines and adipokine in macrophyage cell line RAW264 and 3T3-L1 adipocytes. METHODS: No release was measured as a form of nitrite by Griess method.

Author(s): 
Rim, Hong-Kun
Moon, Phil-Dong
Choi, In-Hwa
Lee, Eun-Hee
Kim, Hyung-Min
Jeong, Hyun-Ja
Publication Title: 
In Vivo (Athens, Greece)

Rhein, an anthraquinone compound, can be found in the rhizome of rhubarb, a traditional Chinese medicine herb showing antitumor activity. In this study, it was observed that rhein induced S-phase arrest through the inhibition of p53, cyclin A and E and it induced apoptosis through the endoplasmic reticulum stress by the production of reactive oxygen species (ROS) and Ca2+ release, mitochondrial dysfunction, and caspase-8, -9 and -3 activation in human tongue cancer cell line (SCC-4). The most efficient induction of apoptosis was observed at 30 microM for 24 h.

Author(s): 
Lai, Wan-Wen
Yang, Jai-Sing
Lai, Kuang-Chi
Kuo, Chao-Lin
Hsu, Cheng-Kuang
Wang, Chien-Kuo
Chang, Ching-Yao
Lin, Jen-Jyh
Tang, Nou-Ying
Chen, Po-Yuan
Huang, Wen-Wen
Chung, Jing-Gung
Publication Title: 
The Journal of Biological Chemistry

Retinoic X receptor (RXR) is a promising target for drug discovery against cancer and metabolic syndromes. Here, we identified a specific RXRα antagonist, danthron, from the traditional Chinese medicine rhubarb. Danthron repressed all tested RXRα-involved response element transcription, including the RXRE, PPRE, FXRE, and LXRE. Results from native PAGE and isothermal titration calorimetry (ITC)-based assays indicated that danthron bound to the tetrameric RXRα-LBD in a specific stoichimetric ratio, and such a binding could influence the corepressor SMRT affinity to the receptor.

Author(s): 
Zhang, Haitao
Zhou, Rong
Li, Li
Chen, Jing
Chen, Lili
Li, Chenjing
Ding, Hong
Yu, Liang
Hu, Lihong
Jiang, Hualiang
Shen, Xu

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