Anti-Arrhythmia Agents

Publication Title: 
Modern Trends in Pharmacopsychiatry

Presently available clinical genetic studies point to a considerable heritability of anxiety disorders (30-67%), with multiple vulnerability genes such as 5-HT1A, 5-HTT, MAO-A, COMT, CCK-B, ADORA2A, CRHR1, FKBP5, ACE, RGS2/7 and NPSR1 suggested by molecular genetic association studies. These genes have been shown to partially interact with each other as well as with environmental factors to shape the overall disease risk in a complex genetic model.

Author(s): 
Domschke, Katharina
Maron, Eduard
Publication Title: 
Arzneimittel-Forschung

The pharmacological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent, on the central nervous system were studied in various experimental animals as compared with those of disopyramide, mexiletine and lidocaine, and the following results were obtained. 1. Acute toxicity of SUN 1165 in mice was similar to that of mexiletine, and twice as potent as compared with that of disopyramide and lidocaine.

Author(s): 
Hirotsu, I.
Kihara, T.
Nakamura, S.
Hattori, Y.
Hatta, M.
Kitakaze, Y.
Takahama, K.
Hashimoto, Y.
Miyata, T.
Ishihara, T.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemisinin (Art) on outward rectifier potassium current in ventricular myocytes. METHODS: In isolated guinea pig ventricular myocytes, the effects of Art on the two components of delayed outward rectifier K+ current (IK), the rapidly activating inward K+ current (IKr), and the slowly rectifying outward K+ current (IKs) were observed by the whole cell patch-clamp technique. RESULTS: Art decreased IK in a concentration-dependent manner.

Author(s): 
Yang, B. F.
Luo, D. L.
Bao, L. H.
Zhang, Y. C.
Wang, H. Z.
Publication Title: 
Acta Pharmacologica Sinica

AIM: To compare the effects of matrine, artemisinin, and tetrandrine on intracellular Ca2+ concentration ([Ca2+]i) in guinea pig ventricular myocytes. METHODS: A single ventricular myocyte was loaded with Fluo 3-acetoxymethyl (Fluo 3-AM). [Ca2+]i was recorded by laser scanning confocal microscope and represented by fluorescence intensity (FI). RESULTS: 1) KCl 60 mmol . L-1 elevated the FI from 299 +/ -19 to 1389 +/- 325 (P < 0.01) in the presence of extracellular Ca2+ 1.8 mmol . L-1. 2) Both matrine and artemisinin at the concentration of 100 micromol .

Author(s): 
Ai, J.
Gao, H. H.
He, S. Z.
Wang, L.
Luo, D. L.
Yang, B. F.
Publication Title: 
PloS One

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently available as over the counter herbal remedy for memory enhancement in children and adults. However, the consumption of herbal drugs has been reported to alter the expression of drug metabolizing enzymes and membrane transporters.

Author(s): 
Singh, Rajbir
Panduri, Jagadeesh
Kumar, Devendra
Kumar, Deepak
Chandsana, Hardik
Ramakrishna, Rachumallu
Bhatta, Rabi Sankar
Publication Title: 
Archives of Internal Medicine

Ayurveda is an East Indian tradition involving the treatment of medical ailments through the use of herbal medications. A previously asymptomatic 62-year-old man with a history of hypertension and stable coronary artery disease developed paresthesias and fascicular and ventricular tachycardia after ingestion of an Ayurveda bowel regimen containing substrates from the Aconitum species, which is a known neurotoxin and cardiotoxin.

Author(s): 
Dhesi, Pavittarpaul
Ng, Rita
Shehata, Michael M.
Shah, Prediman K.
Publication Title: 
PloS One

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently available as over the counter herbal remedy for memory enhancement in children and adults. However, the consumption of herbal drugs has been reported to alter the expression of drug metabolizing enzymes and membrane transporters.

Author(s): 
Singh, Rajbir
Panduri, Jagadeesh
Kumar, Devendra
Kumar, Deepak
Chandsana, Hardik
Ramakrishna, Rachumallu
Bhatta, Rabi Sankar
Publication Title: 
Journal of Experimental Animal Science

The experimental production of a myocardial infarction (MI) in the dog was achieved adopting a new catheter technique. After induction of the MI, a variety of arrhythmias appeared and were classified according to the Lown-classification as more or less severe. The therapy was achieved with antiarrhythmics class 1-111 (Vaughn-Williams classification) for late premature ventricular beats or couplets. Sinus tachycardia was often terminated by occular or sinus carotis pressure or a new selective sinus blocking agent.

Author(s): 
Beyer, M.
Hoffer, H.
Eggeling, T.
Mierdl, S.
Beyer, U.
Hannekum, A.
Publication Title: 
Wiener Medizinische Wochenschrift (1946)

The most important symptoms in bradycardia are vertigo, dizziness and syncopy due to diminished cerebral blood sypply. Cardial symptoms are cardiac insufficiency and angina pectoris. By means of ECG, especially Holter-ECG, carotid sinus massage, atropin test and invasive methods (atrial stimulation, His-bundle ECG) sinu-nodal dysfunction, carotid sinus syndrome, bradyarrhythmia absoluta and AV-block can be diagnosed. Pharmacological treatment is only useful in acute situations. For symptomatic bradyarrhythmias the implantation of a Pacemaker is the therapy of choice.

Author(s): 
Rausch, P.
Jungmair, W.
Kaliman, J. F.
Publication Title: 
Archives Des Maladies Du Coeur Et Des Vaisseaux

The carotid sinus syndrome is a well-known cause of syncope: the cardio-inhibitory forms are the easiest to diagnose and probably the easiest to treat. However, the vasodepressive forms are as common but their outcome is mainly unknown. Eight hundred and fifty-three patients underwent endocavitary electrophysiological studies with invasive blood pressure measurement for unexplained syncope between October 1984 and January 1990. A carotid sinus syndrome was diagnosed in 215 cases.

Author(s): 
Graux, P.
Carlioz, R.
Guyomar, Y.
Lemaire, N.
Rihani, R.
Cornaert, P.
Dutoit, A.
Croccel, L.

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