Anti-Inflammatory Agents

Publication Title: 
The Libyan Journal of Medicine

BACKGROUND: Volatile oils obtained from lemon grass [Cymbopogon citratus (DC.) Stapf, Poaceae family] are used in traditional medicine as remedies for the treatment of various diseases. AIMS: In the present study, lemon grass essential oil (LGEO) was evaluated for its in vivo topical and oral anti-inflammatory effects, and for its in vitro antifungal activity using both liquid and vapor phases. METHODS: The chemical profile of LGEO as determined by gas chromatography-mass spectrometry analysis revealed two major components: geranial (42.2%), and neral (31.5%).

Author(s): 
Boukhatem, Mohamed Nadjib
Ferhat, Mohamed Amine
Kameli, Abdelkrim
Saidi, Fairouz
Kebir, Hadjer Tchoketch
Publication Title: 
Neurology India

OBJECTIVES: We are presenting 20 cases of the intriguing clinico-electromyographic entity, now considered a potassium channel disorder, Neuromyotonia. Our experience with the clinical manifestations, underlying abnormalities and response to various therapies is documented. MATERIALS AND METHODS: Patients with diffuse pain or undulating muscle movements, with or without stiffness were sent for electromyographic and further studies. Patients with "neuromyotonic discharges" were included after exclusion of hypocalcaemia.

Author(s): 
Panagariya, Ashok
Kumar, Hrishikesh
Mathew, Vivek
Sharma, Bhawna
Publication Title: 
Molecular Cancer Therapeutics

Pinitol (3-O-methyl-chiroinositol), a component of traditional Ayurvedic medicine (talisapatra), has been shown to exhibit anti-inflammatory and antidiabetic activities through undefined mechanisms. Because the transcription factor nuclear factor-kappaB (NF-kappaB) has been linked with inflammatory diseases, including insulin resistance, we hypothesized that pinitol must mediate its effects through modulation of NF-kappaB activation pathway. We found that pinitol suppressed NF-kappaB activation induced by inflammatory stimuli and carcinogens. This suppression was not specific to cell type.

Author(s): 
Sethi, Gautam
Ahn, Kwang Seok
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Curcuma longa (turmeric) has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Turmeric constituents include the three curcuminoids: curcumin (diferuloylmethane; the primary constituent and the one responsible for its vibrant yellow color), demethoxycurcumin, and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone, and zingiberone), sugars, proteins, and resins.

Author(s): 
Jurenka, Julie S.
Publication Title: 
Biochemical Pharmacology

Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer.

Author(s): 
Nair, Hareesh B.
Sung, Bokyung
Yadav, Vivek R.
Kannappan, Ramaswamy
Chaturvedi, Madan M.
Aggarwal, Bharat B.
Publication Title: 
Current Drug Targets

Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation.

Author(s): 
Aggarwal, Bharat B.
Prasad, Sahdeo
Reuter, Simone
Kannappan, Ramaswamy
Yadev, Vivek R.
Park, Byoungduck
Kim, Ji Hye
Gupta, Subash C.
Phromnoi, Kanokkarn
Sundaram, Chitra
Prasad, Seema
Chaturvedi, Madan M.
Sung, Bokyung
Publication Title: 
Journal of Biosciences

Mango ginger (Curcuma amada Roxb.) is a unique spice having morphological resemblance with ginger but imparts a raw mango flavour. The main use of mango ginger rhizome is in the manufacture of pickles and culinary preparations. Ayurveda and Unani medicinal systems have given much importance to mango ginger as an appetizer, alexteric, antipyretic, aphrodisiac, diuretic, emollient, expectorant and laxative and to cure biliousness, itching, skin diseases, bronchitis, asthma, hiccough and inflammation due to injuries.

Author(s): 
Policegoudra, R. S.
Aradhya, S. M.
Singh, L.
Publication Title: 
Acta Poloniae Pharmaceutica

The seeds of Alangium salvifolium Linn. have been traditionally reported to exhibit a variety of biological activities, including antidiabetic, anticancer, diuretic, anti-inflammatory, antimicrobial, laxative, and antiepileptic activities. The objective of this study was to verify the traditional claims and to evaluate the seeds of Alangium salvifolium in various organic extracts to screen the antidiabetic, antiepileptic, analgesic and antiinflammatory activities.

Author(s): 
Sharma, Ashish Kumar
Agarwal, Vipin
Kumar, Rajesh
Balasubramaniam, Arumugam
Mishra, Anurag
Gupta, Rajiv
Publication Title: 
Liver International: Official Journal of the International Association for the Study of the Liver

BACKGROUND: Cholestasis is a common disease of the liver. Chronic cholestasis eventually leads to hepatic cirrhosis and fibrosis, and rodent chronic cholestasis models are used to study aspects of fibrosis and cirrhosis. Cholestasis-induced liver injury and fibrosis are associated with increased oxidative stress and inflammation. Few pharmacological therapies exist for treatment of cholestasis or cirrhosis, but it is known that humans with better nutritional intake are less likely to develop certain types of cirrhosis.

Author(s): 
Donepudi, Ajay C.
Aleksunes, Lauren M.
Driscoll, Maureen V.
Seeram, Navindra P.
Slitt, Angela L.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan

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