Anti-Inflammatory Agents

Publication Title: 
Biochemical Pharmacology

Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer.

Author(s): 
Nair, Hareesh B.
Sung, Bokyung
Yadav, Vivek R.
Kannappan, Ramaswamy
Chaturvedi, Madan M.
Aggarwal, Bharat B.
Publication Title: 
Indian Journal of Experimental Biology

Herbal plants with antioxidant activities are widely used in Ayurvedic medicine for cardiac and other problems. Arjunolic acid is one such novel phytomedicine with multifunctional therapeutic applications. It is a triterpenoid saponin, isolated earlier from Terminalia arjuna and later from Combretum nelsonii, Leandra chaeton etc. Arjunolic acid is a potent antioxidant and free radical scavenger.

Author(s): 
Hemalatha, Thiagarajan
Pulavendran, Sivasami
Balachandran, Chidambaram
Manohar, Bhakthavatsalam Murali
Puvanakrishnan, Rengarajulu
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Ajuga bracteosa Wall Ex Benth. (Labiateae) is described in Ayurveda for the treatment of rheumatism, gout, palsy and amenorrhea. AIM OF THE STUDY: The aim of present investigation is to study anti-inflammatory activity of Ajuga bracteosa, to understand possible mechanism of action and to identify the constituents responsible for its activity.

Author(s): 
Gautam, Raju
Jachak, Sanjay M.
Saklani, Arvind
Publication Title: 
Phytotherapy research: PTR

Experimental studies conducted earlier have proved that Phyllanthus emblica (Pe), Plumbago zeylanica (Pz) and Cyperus rotundus (Cr), plants from the medohara group of Ayurveda possess antiatherosclerotic activity. As inflammation is also one of the pathophysiological factors, it was of interest to evaluate whether these drugs exhibit any antiinflammatory activity. Two models of acute inflammation, namely carrageenan induced rat paw edema and acetic acid induced peritonitis in mice were used.

Author(s): 
Dang, G. K.
Parekar, R. R.
Kamat, S. K.
Scindia, A. M.
Rege, N. N.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders. AIM OF THE STUDY: To explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity.

Author(s): 
Talwar, Sahil
Nandakumar, K.
Nayak, Pawan G.
Bansal, Punit
Mudgal, Jayesh
Mor, Vijay
Rao, Chamallamudi Mallikarjuna
Lobo, Richard
Publication Title: 
Plant Foods for Human Nutrition (Dordrecht, Netherlands)

Njavara is an important medicinal rice variety of Kerala, India, widely used in Ayurveda as a 'health food' and in the treatment of rheumatoid arthritis, paralysis, neurodegenerative diseases and in rejuvenation therapy. Phytochemical investigations and spectroscopic studies of the diethyl ether fraction of methanolic extract of Njavara Black (NB) rice bran gave three important compounds namely, tricin and two rare flavonolignans- tricin 4'-O-(erythro-β-guaiacylglyceryl) ether and tricin 4'-O-(threo-β-guaiacylglyceryl) ether.

Author(s): 
Mohanlal, Smitha
Parvathy, Rathnam
Shalini, Vasantha
Helen, Antony
Jayalekshmy, Ananthasankaran
Publication Title: 
Clinical Pharmacokinetics

Non-steroidal anti-inflammatory drug (NSAID) intake is associated with high prevalence of gastrointestinal or cardiovascular adverse effects. All efforts to develop NSAIDs that spare the gastrointestinal tract and the cardiovasculature are still far from achieving a breakthrough. In the last two decades, preparations of the gum resin of Boswellia serrata (a traditional ayurvedic medicine) and of other Boswellia species have experienced increasing popularity in Western countries. Animal studies and pilot clinical trials support the potential of B.

Author(s): 
Abdel-Tawab, Mona
Werz, Oliver
Schubert-Zsilavecz, Manfred
Publication Title: 
Current Drug Targets

Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation.

Author(s): 
Aggarwal, Bharat B.
Prasad, Sahdeo
Reuter, Simone
Kannappan, Ramaswamy
Yadev, Vivek R.
Park, Byoungduck
Kim, Ji Hye
Gupta, Subash C.
Phromnoi, Kanokkarn
Sundaram, Chitra
Prasad, Seema
Chaturvedi, Madan M.
Sung, Bokyung
Publication Title: 
Inflammopharmacology

The leaves of Jasminum grandiflorum (JG) are in clinical use in Ayurveda for wound management. Since, oxidative stress and inflammation are the primary causes in delayed wound healing, so here its antioxidant and anti-inflammatory activities have been investigated using in vitro as well as in vivo models. The solvent-free methanolic extract of dried leaves of JG were tested for its trapping capacity toward pre-generated ABTS•+ radicals, instantly generated superoxide and hydroxyl radicals, along with metal chelation property, reducing power and total phenolic content.

Author(s): 
Chaturvedi, Adya Prasad
Tripathi, Yamini Bhusan
Publication Title: 
La Clinica Terapeutica

INTRODUCTION AND OBJECTIVE: Curcuma longa (CL) or turmeric is an Ayurvedic herb that has been traditionally used to treat inflammatory conditions like rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is a well established experimental auto-immune mediated polyarthritis in susceptible strains of rodents. The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract.

Author(s): 
Taty Anna, K.
Elvy Suhana, M. R.
Das, S.
Faizah, O.
Hamzaini, A. H.

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