Anti-Obesity Agents

Publication Title: 
The Psychiatric Clinics of North America

The two specialty psychological therapies of CBT and IPT remain the treatments of choice for the full range of BED patients, particularly those with high levels of specific eating disorder psychopathology such as overvaluation of body shape and weight. They produce the greatest degree of remission from binge eating as well as improvement in specific eating disorder psychopathology and associated general psychopathology such as depression. The CBT protocol evaluated in the research summarized above was the original manual from Fairburn and colleagues.

Author(s): 
Wilson, G. Terence
Publication Title: 
Alternative Therapies in Health and Medicine

CONTEXT: In India, vaidyas (Ayurvedic physicians) traditionally administer triphala and its constituents as therapeutic agents for promoting digestion and satiety. OBJECTIVE: The research team performed the present study to investigate the effects of triphala and its constituents (T bellirica [bibhitaki], T chebula [haritaki], and E officinalis [amalaki]) on the dietary induction of obesity (diet-induced obesity [DIO]), and other symptoms of visceral obesity syndrome, in mice fed a high-fat diet (HFD).

Author(s): 
Gurjar, Shaifali
Pal, Anuradha
Kapur, Suman
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

As part of an effort to review current understanding of the mechanisms by which caloric restriction (CR) extends maximum life span, the authors of the present review were requested to develop a list of key issues concerning the potential role of neuroendocrine systems in mediating these effects. It has long been hypothesized that failure of specific neuroendocrine functions during aging leads to key age-related systemic and physiological failures, and more recently it has been postulated that physiological neuroendocrine responses to CR may increase life span.

Author(s): 
Mobbs, C. V.
Bray, G. A.
Atkinson, R. L.
Bartke, A.
Finch, C. E.
Maratos-Flier, E.
Crawley, J. N.
Nelson, J. F.
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Marx, Jean
Publication Title: 
Drug Safety: An International Journal of Medical Toxicology and Drug Experience

Obesity is a major health problem worldwide. It is associated with cardiovascular diseases, diabetes mellitus and decreased longevity. In managing obesity, diet and exercise are essential; pharmacological therapy may be added for obese patients or overweight patients with cardiovascular risk factors. Sibutramine is a serotonergic and adrenergic drug that reduces food intake and increases thermogenesis. It reduces bodyweight by about 4.2?kg after 12 months, and improves blood glucose and lipids; however, it can increase heart rate and blood pressure.

Author(s): 
Cheung, Bernard M. Y.
Publication Title: 
Expert Opinion on Therapeutic Patents

INTRODUCTION: Reversible acetylation is a key post-translational modification of target proteins. Sirtuin deacetylases represent the homolog of the yeast silent information regulator (SIR2). Although seven sirtuins have been found in mammals, all sirtuin activators described to date act through SIRT1.

Author(s): 
Villalba, JosÈ M.
de Cabo, Rafael
Alcain, Francisco J.
Publication Title: 
Toxicology Mechanisms and Methods

LI85008F is a novel synergistic composition of Moringa oleifera, Murraya koenigi, and Curcuma longa. These herbs are well recognized and widely used in ayurvedic system of medicine for treating a variety of diseases and are also have been used for culinary purposes for thousands of years. LI85008F inhibits preadipocyte differentiation and potentiates lipid breakdown in mature adipocytes. In diet-induced obese rats, LI85008F significantly reduced weight gain and improved serum adiponectin levels. These findings motivated the authors to determine the broad-spectrum safety of LI85008F.

Author(s): 
Krishnaraju, A. V.
Sundararaju, D.
Srinivas, P.
Rao, C. V.
Sengupta, K.
Trimurtulu, G.
Publication Title: 
Journal of Natural Medicines

In Ayurvedic medicine, Salacia reticulata is known to be useful against various metabolic diseases, including diabetes and obesity. In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months.

Author(s): 
Shimada, Tsutomu
Nagai, Eiichi
Harasawa, Yukiko
Akase, Tomoko
Aburada, Takashi
Iizuka, Seiichi
Miyamoto, Ken-ichi
Aburada, Masaki
Publication Title: 
Journal of Natural Medicines

Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring countries, and the fruit of this plant has been reported to have hypoglycemic and hypolipidemic effects. In this study, we investigated the preventive effect of a hot water extract of T.

Author(s): 
Makihara, Hiroko
Shimada, Tsutomu
Machida, Eriko
Oota, Masatomi
Nagamine, Rika
Tsubata, Masahito
Kinoshita, Kaoru
Takahashi, Kunio
Aburada, Masaki
Publication Title: 
Chinese Journal of Integrative Medicine

Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and develop new anti-obesity drugs through herbal sources to minimize adverse reactions associated with the present anti-obesity drugs. The use of natural products as medicine has been documented for hundreds of years in various traditional systems of medicines throughout the world.

Author(s): 
Vasudeva, Neeru
Yadav, Neerja
Sharma, Surendra Kumar

Pages

Subscribe to RSS - Anti-Obesity Agents