Antibodies, Monoclonal, Humanized

Publication Title: 
BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy

Systemic lupus erythematosus (SLE) is a complex heterogeneous disease, posing challenges to clinical trials. As in other autoimmune diseases, B-lymphocytes play a central role in lupus pathogenesis. The finding that selection and survival of B cells are controlled by a variety of signals, including those provided by the longevity factor BAFF (B-cell activating factor), also called BLyS (B-lymphocyte stimulator), led to preclinical trials that revealed that BAFF represents a promising therapeutic target for human lupus. Belimumab is a fully human monoclonal antibody directed against BAFF.

Author(s): 
Zouali, Moncef
Uy, Eugene A.
Publication Title: 
Health Services Research

OBJECTIVES: To examine the impact of benefit generosity and household health care financial burden on the demand for specialty drugs in the treatment of rheumatoid arthritis (RA). DATA SOURCES/STUDY SETTING: Enrollment, claims, and benefit design information for 35 large private employers during 2000-2005. STUDY DESIGN: We estimated multivariate models of the effects of benefit generosity and household financial burden on initiation and continuation of biologic therapies.

Author(s): 
Karaca-Mandic, Pinar
Joyce, Geoffrey F.
Goldman, Dana P.
Laouri, Marianne
Publication Title: 
Expert Opinion on Biological Therapy

IMPORTANCE OF THE FIELD: Type 1 diabetes mellitus (T1D) is a T-cell mediated autoimmune disease with selective destruction of beta cells. Immunological interventions are directed at arresting the loss of beta-cell function with the promise that this will make it easier for patients to control their glucose levels. AREAS COVERED IN THIS REVIEW: This review provides a summary of the preclinical and clinical research published between 1992 and 2009 using teplizumab and other anti-CD3 antibodies to arrest the loss of beta-cell function in new onset T1D.

Author(s): 
Masharani, Umesh B.
Becker, Joseph
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: The therapeutic effect of trastuzumab monoclonal antibody (mAb) therapy has been shown to be partially dependent on functional natural killer (NK) cells. Novel agents that enhance NK cell function could potentially improve the antitumor effect of trastuzumab. We recently identified polysaccharide krestin (PSK), a natural product extracted from medicinal mushroom Trametes versicolor, as a potent toll-like receptor 2 (TLR2) agonist. This study was undertaken to evaluate the effect of PSK on human NK cells and the potential of using PSK to enhance HER2-targeted mAb therapy.

Author(s): 
Lu, Hailing
Yang, Yi
Gad, Ekram
Inatsuka, Carol
Wenner, Cynthia A.
Disis, Mary L.
Standish, Leanna J.
Publication Title: 
Nutrients

PURPOSE: Rare spontaneous remissions from age-related macular degeneration (AMD) suggest the human retina has large regenerative capacity, even in advanced age. We present examples of robust improvement of retinal structure and function using an OTC oral resveratrol (RV) based nutritional supplement called Longevinex® or L/RV (circa 2004, Resveratrol Partners, LLC, Las Vegas, NV, USA). RV, a polyphenolic phytoalexin caloric-restriction mimic, induces hormesis at low doses with widespread beneficial effects on systemic health. RV alone inhibits neovascularization in the murine retina.

Author(s): 
Richer, Stuart
Stiles, William
Ulanski, Lawrence
Carroll, Donn
Podella, Carla
Publication Title: 
Chinese Journal of Cancer

Either cetuximab or bevacizumab can improve the survival of patients with metastastic colorectal cancer (mCRC) if administered combided with cytotoxic agents. However, the effect of two or more target agents in combination is uncertain in these patients. Here, we reported a patient with mCRC successfully treated by a combination of target agents after the failure of chemotherapy.

Author(s): 
Xia, Liang-Ping
Wu, Pei-Hong
Xia, Jian-Chuan
Zhang, Bei
Guan, Zhong-Zhen
Wan, De-Sen
Guo, Gui-Fang
Zeng, Yi-Xin
Publication Title: 
Der Nervenarzt

BACKGROUND: The increasing therapeutic options for relapsing-remitting multiple sclerosis require a specific treatment and risk management to recognize the individual response as well as potential side effects. To switch from pure MS documentation to MS management by implementing a new multiple sclerosis management and documentation tool may be of importance. METHOD: This article presents the novel computer-based patient management system "multiple sclerosis management system 3D" (MSDS 3D).

Author(s): 
Schultheiss, T.
Kempcke, R.
Kratzsch, F.
Eulitz, M.
Pette, M.
Reichmann, H.
Ziemssen, T.
Publication Title: 
Expert Review of Clinical Pharmacology

The treatment of diabetic macular edema may be evolving from a laser ablative approach into a pharmacotherapeutic approach. The exponential growth that has occurred over the past decade in the retinal pharmacotherapy field has led to the development of several pharmacotherapies for retinal vascular diseases such as diabetic macular edema. Many of these agents, in the form of intravitreal injections or sustained delivery devices, have already undergone clinical trial testing for safety and efficacy and many others are currently being similarly evaluated.

Author(s): 
Al Shamsi, Hanan
Ghazi, Nicola G.
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