Anticoagulants

Publication Title: 
The Permanente Journal

INTRODUCTION: Theoretically, acupuncture in anticoagulated patients could increase bleeding risk. However, precise estimates of bleeding complication rates from acupuncture in anticoagulated patients have not been systematically examined. OBJECTIVE: To critically evaluate evidence for safety of acupuncture in anticoagulated patients. METHODS: We searched PubMed, EMBASE, the Physiotherapy Evidence Database, and Google Scholar. RESULTS: Of 39 potentially relevant citations, 11 met inclusion criteria: 2 randomized trials, 4 case series, and 5 case reports.

Author(s): 
McCulloch, Michael
Nachat, Arian
Schwartz, Jonathan
Casella-Gordon, Vicki
Cook, Joseph
Publication Title: 
The Journal of Cardiovascular Nursing

The formation of blood clots is a significant threat to individuals with limited mobility, whether in the hospital or recovering in an outpatient setting. Prevention of deep vein thrombosis and pulmonary embolism has been found to be cost-effective when compared with treating an existing thrombosis. Despite these positive findings, compliance with the clinical practice guidelines is less than ideal.

Author(s): 
Long, Janet B.
Publication Title: 
Journal of thrombosis and haemostasis: JTH

BACKGROUND: Thromboprophylaxis with rivaroxaban (R) is superior to enoxaparin in patients undergoing major orthopedic surgery (MOS). However, rivaroxaban has never been directly compared with fondaparinux (F), which also shows superior efficacy over enoxaparin. The clinical impact of switching from fondaparinux to rivaroxaban thromboprophylaxis is unclear. OBJECTIVES: To evaluate the efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in unselected patients undergoing MOS.

Author(s): 
Beyer-Westendorf, J.
L¸tzner, J.
Donath, L.
Radke, O. C.
Kuhlisch, E.
Hartmann, A.
Weiss, N.
Werth, S.
Publication Title: 
The Practitioner
Author(s): 
Blackburn, E. K.
Publication Title: 
Lancet
Author(s): 
Blackburn, E. K.
Shinton, N. K.
Publication Title: 
The American Journal of Cardiology

With the introduction of novel oral anticoagulants (NOACs), the factors driving anticoagulant selection in atrial fibrillation (AF) in real-world practice are unclear. The goal was to examine whether and to what extent utilization has been driven by predictions of stroke risk (treatment benefit), bleeding risk (treatment harm), or prescription benefits' coverage. We extracted a cohort of patients with nonvalvular AF initiating anticoagulation from October 2010 to December 2012 from a large US database of commercial and Medicare supplement claims.

Author(s): 
Lauffenburger, Julie C.
Farley, Joel F.
Gehi, Anil K.
Rhoney, Denise H.
Brookhart, M. Alan
Fang, Gang
Publication Title: 
Medical Science
Author(s): 
Erslev, A. J.
Publication Title: 
Lancet

Concurrent use of herbs may mimic, magnify, or oppose the effect of drugs.

Author(s): 
Fugh-Berman, A.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Stem bark gum resin extract of Boswellia serrata is traditionally used in India for its hemostatic, antiinflammatory and cardiovascular health effects and it is named as Śallakī in Ayurvedic medicine. AIM OF THE STUDY: This study was conducted to evaluate the antioxidative and antithrombotic properties of stem bark gum resin extracts of Boswellia serrata (BS). MATERIALS AND METHODS: The inhibitory activity of the BSWE and BSAE on FeCl(3) induced lipid peroxidation (in vitro) in rat liver and heart homogenates was measured spectrophotometrically.

Author(s): 
Kokkiripati, Praveen K.
Bhakshu, Lepakshi Md
Marri, Swathi
Padmasree, K.
Row, Anupama T.
Raghavendra, Agepati S.
Tetali, Sarada D.
Publication Title: 
The British Journal of Nutrition

Amla (Emblica officinalis Gaertn.) has been used for many centuries in traditional Indian Ayurvedic formulations for the prevention and treatment of many inflammatory diseases. The present study evaluated the anti-inflammatory and anticoagulant properties of amla fruit extract. The amla fruit extract potentially and significantly reduced lipopolysaccharide (LPS)-induced tissue factor expression and von Willebrand factor release in human umbilical vein endothelial cells (HUVEC) in vitro at clinically relevant concentrations (1-100 μg/ml).

Author(s): 
Rao, Theertham Pradyumna
Okamoto, Takayuki
Akita, Nobuyuki
Hayashi, Tatsuya
Kato-Yasuda, Naomi
Suzuki, Koji

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