Antidepressive Agents, Second-Generation

Publication Title: 
Sleep Medicine Reviews

In concert with growing public interest in complementary and alternative medicine (CAM), these therapies and products have been increasingly studied over the past two decades for the treatment of sleep disorders. While systematic reviews have been conducted on acupuncture and valerian in the treatment of insomnia, to date no comprehensive review has been conducted on all major CAM treatments.

Author(s): 
Sarris, Jerome
Byrne, Gerard J.
Publication Title: 
Preventive Medicine

OBJECTIVE: To assess the preferred methods to quit smoking among current smokers. METHOD: Cross-sectional, population-based study conducted in Lausanne between 2003 and 2006 including 988 current smokers. Preference was assessed by questionnaire. Evidence-based (EB) methods were nicotine replacement, bupropion, physician or group consultations; non-EB-based methods were acupuncture, hypnosis and autogenic training.

Author(s): 
Marques-Vidal, Pedro
Melich-Cerveira, João
Paccaud, Fred
Waeber, Gérard
Vollenweider, Peter
Cornuz, Jacques
Publication Title: 
Sleep Medicine Reviews

In concert with growing public interest in complementary and alternative medicine (CAM), these therapies and products have been increasingly studied over the past two decades for the treatment of sleep disorders. While systematic reviews have been conducted on acupuncture and valerian in the treatment of insomnia, to date no comprehensive review has been conducted on all major CAM treatments.

Author(s): 
Sarris, Jerome
Byrne, Gerard J.
Publication Title: 
Preventive Medicine

OBJECTIVE: To assess the preferred methods to quit smoking among current smokers. METHOD: Cross-sectional, population-based study conducted in Lausanne between 2003 and 2006 including 988 current smokers. Preference was assessed by questionnaire. Evidence-based (EB) methods were nicotine replacement, bupropion, physician or group consultations; non-EB-based methods were acupuncture, hypnosis and autogenic training.

Author(s): 
Marques-Vidal, Pedro
Melich-Cerveira, João
Paccaud, Fred
Waeber, Gérard
Vollenweider, Peter
Cornuz, Jacques
Publication Title: 
Annals of Internal Medicine

DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the comparative effectiveness of treatment with second-generation antidepressants versus nonpharmacologic treatments for major depressive disorder in adults. METHODS: This guideline is based on a systematic review of published, English-language, randomized, controlled trials from 1990 through September 2015 identified using several databases and through hand searches of references of relevant studies.

Author(s): 
Qaseem, Amir
Barry, Michael J.
Kansagara, Devan
Clinical Guidelines Committee of the American College of Physicians
Publication Title: 
Depression and Anxiety

BACKGROUND: Scant research has examined the effect of neuropsychological (NP) functioning on treatment outcome in pediatric obsessive-compulsive disorder (OCD). This study sought to address this gap in existing research. METHODS: A total of 63 youths were included in this study and asked to complete the Rey-Osterrieth Complex Figure (ROCF) and specific subtests of the Wechsler Intelligence Scale for Children, Third Edition (WISC-III).

Author(s): 
Flessner, Christopher A.
Allgair, Amy
Garcia, Abbe
Freeman, Jennifer
Sapyta, Jeffrey
Franklin, Martin E.
Foa, Edna
March, John
Publication Title: 
The Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine

Finely tuning levels of the key neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) during early life is essential for brain development and setting pathways for health and disorder across the early life span. Given the central role of 5-HT in brain development, regulation of mood, stress reactivity, and risk for psychiatric disorders, alterations in 5-HT signaling early in life have critical implications for behavior and mental health in childhood and adolescence.

Author(s): 
Oberlander, Tim F.
Publication Title: 
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

Chronic social defeat stress in mice produces a susceptible phenotype characterized by several behavioral abnormalities consistent with human depression that are reversed by chronic but not acute exposure to antidepressant medications. Recent work in addiction models demonstrates that the transcription factor ?FosB and protein kinase calmodulin-dependent protein kinase II (CaMKII) are co-regulated in nucleus accumbens (NAc), a brain reward region implicated in both addiction and depression models including social defeat.

Author(s): 
Robison, A. J.
Vialou, Vincent
Sun, Hao-Sheng
LabontÈ, Benoit
Golden, Sam A.
Dias, Caroline
Turecki, Gustavo
Tamminga, Carol
Russo, Scott
Mazei-Robison, Michelle
Nestler, Eric J.
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the patients' antidepressant response. METHOD: A total of 232 Mexican Americans who met DSM-IV criteria for major depressive disorder were randomly assigned to receive 8 weeks of double-blind treatment with desipramine (50-200 mg/day) or fluoxetine (10-40 mg/day) after a 1-week placebo lead-in period.

Author(s): 
Wong, Ma-Li
Dong, Chuanhui
Flores, Deborah L.
Ehrhart-Bornstein, Monika
Bornstein, Stefan
Arcos-Burgos, Mauricio
Licinio, Julio
Publication Title: 
Molecular Psychiatry

Bipolar disorder (BD) is a chronic psychiatric disorder of public health importance affecting >1% of the Swedish population. Despite progress, patients still suffer from chronic mood switches with potential severe consequences. Thus, early detection, diagnosis and initiation of correct treatment are critical.

Author(s): 
Hayashi, A.
Le Gal, K.
Sˆdersten, K.
Vizlin-Hodzic, D.
≈gren, H.
Funa, K.

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