Antidepressive Agents, Tricyclic

Publication Title: 
Journal of Toxicology. Clinical Toxicology

Cyclic antidepressant overdose involves a risk of generalized seizures and cardiovascular disturbances. We have conducted a retrospective study to test the hypothesis of a relationship between generalized seizures and the onset of arrhythmia, hypotension or cardiac arrest during cyclic antidepressant intoxication. Patients who had seizures after ingestion of toxic amounts of tri- or tetracyclic antidepressants were included. Limb-lead QRS complex duration and systolic blood pressure were recorded before and after seizure.

Author(s): 
Taboulet, P.
Michard, F.
Muszynski, J.
Galliot-Guilley, M.
Bismuth, C.
Publication Title: 
Forschende Komplementärmedizin (2006)

We present the case of a 76-year-old female patient with complex psychosomatic complaints. The patient suffered from depression, panic attacks, chronic pain and dyspepsia with nausea and loss of appetite. In addition to the conventional psychosomatic care, the patient received individual homeopathic treatment for her dyspepsia, resulting in complete remission. The therapeutic value of homeopathy in the present case is discussed in the context of recent findings from placebo research.

Author(s): 
Zimmermann-Viehoff, Frank
Bergander, Bernd
Meissner, Karin
Deter, Hans-Christian
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

BACKGROUND: Migraine headache affects approximately 11 million adults in the United States. Spinal manipulation is a common alternative therapy for headaches, but its efficacy compared with standard medical therapies is unknown. OBJECTIVE: To measure the relative efficacy of amitriptyline, spinal manipulation and the combination of both therapies for the prophylaxis of migraine headache. DESIGN: A prospective, randomized, parallel-group comparison. After a 4-wk baseline period, patients were randomly assigned to 8 wk of treatment, after which there was a 4-wk follow-up period.

Author(s): 
Nelson, C. F.
Bronfort, G.
Evans, R.
Boline, P.
Goldsmith, C.
Anderson, A. V.
Publication Title: 
Neuroscience Letters

An increased vulnerability to pain complaints, along with a simultaneous increase in experimental pain thresholds, shows the paradoxical phenomenon of pain perception in depressive patients. Clomipramine, a tricyclic antidepressant, could also ameliorate syndromes in chronic pain patients. However, few studies have focused on the effect of antidepressants on experimental pain thresholds.

Author(s): 
Li, Bing
Yang, Chang-Jiang
Yue, Na
Liu, Yang
Yu, Jin
Wang, Yan-Qing
Liu, Qiong
Wu, Gen-Cheng
Publication Title: 
The New England Journal of Medicine

A 19-year-old man is brought to his primary physician by his father, who explains that his son washes his hands a hundred times a day, will not touch anything that has been touched by someone else without scrubbing it first, and has a fear of germs that has left him isolated in his bedroom, unable to eat, and wishing he were dead. Although the father reports that his son has always been finicky, this problem started approximately 2 years ago and has gradually become completely disabling. How should this patient be evaluated and treated?

Author(s): 
Grant, Jon E.
Publication Title: 
Family Practice

BACKGROUND: A number of different therapies have been used for postherpetic neuralgia. We decided to conduct a systematic review of existing randomized controlled trials. OBJECTIVE: To determine the efficacy of available therapies for relieving the pain of established postherpetic neuralgia. METHODS: We performed a systematic review, including meta-analysis, of existing randomized controlled trials. Eleven published trials and one unpublished trial were identified which met the inclusion criteria and were included in the current review.

Author(s): 
Volmink, J.
Lancaster, T.
Gray, S.
Silagy, C.
Publication Title: 
PLoS medicine

BACKGROUND: Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN.

Author(s): 
Hempenstall, Kathleen
Nurmikko, Turo J.
Johnson, Robert W.
A'Hern, Roger P.
Rice, Andrew S. C.
Publication Title: 
Clinical Journal of Oncology Nursing

Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a significant, debilitating symptom resulting from the administration of neurotoxic chemotherapy for the treatment of cancer. CIPN is an important consequence of cancer treatment because of its potential impact on physical functioning and quality of life. Oncology nurses play an important role in assessing, monitoring, and educating clients about CIPN.

Author(s): 
Visovsky, Constance
Collins, Mary
Abbott, Linda
Aschenbrenner, Julie
Hart, Connie
Publication Title: 
Journal of Rehabilitation Medicine

OBJECTIVE: To evaluate the effectiveness of acupuncture for fibromyalgia. METHODS: Fifty-eight women with fibromyalgia were allocated randomly to receive either acupuncture together with tricyclic antidepressants and exercise (n=34), or tricyclic antidepressants and exercise only (n=24). Patients rated their pain on a visual analogue scale. A blinded assessor evaluated both the mean pressure pain threshold value over all 18 fibromyalgia points and quality of life using SF-36.

Author(s): 
Targino, Rosa Alves
Imamura, Marta
Kaziyama, Helena H. S.
Souza, Luiz P. M.
Hsing, Wu Tu
Furlan, Andrea D.
Imamura, Satiko Tomikawa
Azevedo Neto, Raymundo Soares

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