Antidiarrheals

Publication Title: 
Pharmaceutical Biology

Context Chebulae Fructus is used as an herbal remedy for diarrhoea in traditional Chinese medicine. However, there is no scientific evidence to support its antidiarrhoeal activity. Objective This study evaluates the antidiarrhoeal properties of Chebulae Fructus aqueous extract (CFAE) and determines the active fraction. Materials and methods The antidiarrhoeal effect of CFAE (200-800?mg/kg) was investigated by determining the wet dropping, intestinal transit in BALB/c mice and enteropooling in Wister rats.

Author(s): 
Sheng, Zunlai
Yan, Xin
Zhang, Ruili
Ni, Huilin
Cui, Yuanxu
Ge, Junwei
Shan, Anshan
Publication Title: 
Alimentary Pharmacology & Therapeutics

This review summarizes the clinical evidence to support current therapies in irritable bowel syndrome (IBS). Fibre is indicated at a dose of at least 12 g per day in patients with constipation-predominant IBS. Loperamide (and probably other opioid agonists) are of proven benefit in diarrhoea-predominant IBS; loperamide may also aid continence by enhancing resting anal tone. In general, smooth muscle relaxants are best used sparingly, on an 'as needed' basis, as their overall efficacy is unclear.

Author(s): 
Camilleri, M.
Publication Title: 
Gastroenterology

Irritable bowel syndrome (IBS) is the most common disorder diagnosed by gastroenterologists and one of the more common ones encountered in general practice. The overall prevalence rate is similar (approximately 10%) in most industrialized countries; the illness has a large economic impact on health care use and indirect costs, chiefly through absenteeism. IBS is a biopsychosocial disorder in which 3 major mechanisms interact: psychosocial factors, altered motility, and/or heightened sensory function of the intestine.

Author(s): 
Camilleri, M.
Publication Title: 
Alimentary Pharmacology & Therapeutics

This consensus document reviews the current status of the epidemiology, social impact, patient quality of life, pathophysiology, diagnosis and treatment of irritable bowel syndrome. Current evidence suggests that two major mechanisms may interact in irritable bowel syndrome: altered gastrointestinal motility and increased sensitivity of the intestine. However, other factors, such as psychosocial factors, intake of food and prior infection, may contribute to its development.

Author(s): 
Camilleri, M.
Heading, R. C.
Thompson, W. G.
Publication Title: 
Journal of Ethnopharmacology

Preliminary pharmacological studies were performed on the methanol extract of Bixa orellana L. (Bixaceae) leaves to investigate neuropharmacological, anticonvulsant, analgesic, antidiarrhoeal activity and effect on gastrointestinal motility. All studies were conducted in mice using doses of 125, 250 and 500 mg/kg of body weight. In the pentobarbitone-induced hypnosis test, the extract statistically reduced the time for the onset of sleep at 500 mg/kg dose and (dose-dependently) increased the total sleeping time at 250 and 500 mg/kg dose.

Author(s): 
Shilpi, Jamil Ahmad
Taufiq-Ur-Rahman, Md
Uddin, Shaikh Jamal
Alam, Md Shahanur
Sadhu, Samir Kumar
Seidel, Véronique
Publication Title: 
Applied Psychophysiology and Biofeedback

This study was conducted to evaluate the comparative effect of yogic and conventional treatment in diarrhea-predominant irritable bowel syndrome (IBS) in a randomized control design. The patients were 22 males, aged 20-50 years, with confirmed diagnosis of diarrhea-predominant IBS.

Author(s): 
Taneja, Indu
Deepak, K. K.
Poojary, G.
Acharya, I. N.
Pandey, R. M.
Sharma, M. P.
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: Asparagus racemosus Wild root has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. However, the claims of Ayurveda need to be validated by a suitable experimental model. Therefore, the present study was undertaken to evaluate the effect of ethanol and aqueous extracts of Asparagus racemosus for its antidiarrhoeal potential against several experimental models of diarrhoea in Albino Wistar rats.

Author(s): 
Venkatesan, N.
Thiyagarajan, Vadivu
Narayanan, Sathiya
Arul, Arokya
Raja, Sundararajan
Vijaya Kumar, Sengodan Gurusamy
Rajarajan, Thandavarayan
Perianayagam, James Britto
Publication Title: 
Methods and Findings in Experimental and Clinical Pharmacology

Recurrent diarrhea is prevalent in developing countries, particularly in tropical regions. A natural based antidiarrheal home remedy can serve as an ideal health tool to limit diarrhea-related morbidity and mortality. In the traditional Indian medical science of Ayurveda, nutmeg is one such plant said to possess antidiarrheal activity. A study was therefore planned to assess the various pharmacological effects (antidiarrheal, sedative, analgesic and blood pressure) of nutmeg.

Author(s): 
Grover, J. K.
Khandkar, S.
Vats, V.
Dhunnoo, Y.
Das, D.
Publication Title: 
Journal of Ethnopharmacology

Mebarid, an ayurvedic formulation, was tested for its anti-diarrhoeal, anti-ulcer and anti-motility activities in animals. Mebarid was investigated at four dose levels of 125, 250, 500 mg/kg BW and 1g/kg BW The methods of castor oil-induced diarrhoea and pylorus-ligation-induced ulcers in rats were used to evaluate the anti-diarrhoeal and anti-ulcer activity, respectively, while charcoal meal test in mice was the method used for testing its anti-motility effect. Mebarid was found to have significant activity in all the three models.

Author(s): 
Bafna, Pallavi
Bodhankar, Subhash
Publication Title: 
Journal of Ethnopharmacology

Piper chaba Hunter (Piperaceae) is a common pepper in the southern part of Bangladesh. Various parts of this plant have been extensively used in different traditional formulations including ayurveda. In order to rationalize the ethnomedical uses of this plant in a number of ailments, the methanol extract of the stem bark was subjected to preliminary evaluation for analgesic, anti-inflammatory, diuretic, anti-diarrhoeal, effect on gastrointestinal motility and CNS depressant activity in mice and rat at 125, 250 and 500 mg/kg body weight doses.

Author(s): 
Taufiq-Ur-Rahman, Md
Shilpi, Jamil Ahmad
Ahmed, Muniruddin
Faiz Hossain, Chowdhury

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