Antifungal Agents

Publication Title: 
Journal of the European Academy of Dermatology and Venereology: JEADV

Seborrheic dermatitis (SD) is normally treated with topical corticosteroids and antifungals. Oral therapies can be prescribed in severe or unresponsive cases. This review aims to assess the quantity and quality of published reports on oral therapies for SD. MEDLINE and Embase databases and the reference listings of publications were searched for any publication using oral treatment for SD. The quality of the included publications was assessed using a modified 27 item checklist by Downs and Black.

Gupta, A. K.
Richardson, M.
Paquet, M.
Publication Title: 

In vitro studies of water extracts of plants such as Terminalia chebula, Punica granatum, Delonix regia and Emblica officinalis were found to be detrimental to test dermatophytes.

Dutta, B. K.
Rahman, I.
Das, T. K.
Publication Title: 
Phytotherapy research: PTR

In this study, twenty-eight South Indian medicinal plants were screened for their anti-fungal activity against six species of fungi (Trichophyton mentagrophytes, T. rubrum, T. soudanense, Candida albicans, Torulopsis glabrata, and C. krusei). Three plant species extracts, Celastrus paniculatus, Eriodendron anfractuosum and Ficus glomerata showed inhibitory activity. An aqueous extract of galls of Terminalia chebula showed inhibitory effects on three dermatophytes (Trichophyton spp.) and three yeasts (Candida spp.). Seeds extract of T. chebula inhibited only the growth of T. glabrata.

Vonshak, A.
Barazani, O.
Sathiyamoorthy, P.
Shalev, R.
Vardy, D.
Golan-Goldhirsh, A.
Publication Title: 

In vitro anticandidal activity of methanol extracts of 42 plant species of 29 families used in Iranian folkloric medicine were evaluated at 20 mg/ml concentration against Clotrimazole-resistant Candida albicans. Nineteen plant species in 16 families showed anticandidal activities. The lowest MIC of 0.62 mg/ml belonged to Terminalia chebula and Thymus vulgaris.

Bonjar, G. H. Shahidi
Publication Title: 
Microbial Ecology

The paper explores fungal infection and aflatoxin B1 contamination of six medicinal plant samples viz. Adhatoda vasica Nees, Asparagus racemosus Linn., Evolvulus alsinoides Linn., Glycyrrhiza glabra Linn., Plumbago zeylanica Linn. and Terminalia chebula Retz. A total of 858 fungal isolates were detected from the raw materials. Maximum number of fungal isolates was detected from A. racemosus (228). The genus Aspergillus was found to be the most dominant genus causing infection to most of the raw materials. Among the 32 isolates of A.

Singh, Priyanka
Srivastava, Bhawana
Kumar, Ashok
Dubey, N. K.
Publication Title: 
Pakistan journal of biological sciences: PJBS

The present study describes the antifungal potential of fruit and powdered ingredients of triphala churna, i.e. Emblica officinalis (Garetn.) (Amla), Terminalia bellirica (Gaertn.) Roxb. (Baheda) and Terminalia chebula (Retz.) (Harada), collected from the market of Gwalior (M.P.), India. Water extracts of all the fruits and powdered samples were tested (in vitro) for their antifungal activities by poisoned food technique against different Aspergillus species (A. flavus, A. fumigatus, A. versicolor, A. terreus and A. niger) associated with them during storage.

Gautam, Ajay K.
Avasthi, Shubhi
Sharma, Anu
Bhadauria, Rekha
Publication Title: 
Journal of Microbiology (Seoul, Korea)

In this study, a tropical endophytic fungus, Alternaria alternata Tche-153 was isolated from a Thai medicinal plant Terminalia chebula Rezt. The ethyl acetate extract prepared from the fermentation broth exhibited significant ketoconazole-synergistic activity against Candida albicans. Bioassay-directed fractionation of the ethyl acetate extract led to the isolation of altenusin (1), isoochracinic acid (2), and altenuic acid (3) together with 2,5-dimethyl-7-hydroxychromone (4).

Phaopongthai, Jatuporn
Wiyakrutta, Suthep
Meksuriyen, Duangdeun
Sriubolmas, Nongluksna
Suwanborirux, Khanit
Publication Title: 

Dermatophytes are the most common causative agents of cutaneous mycosis and remain a major public health problem in spite of the availability of an increasing number of antifungal drugs. It was, therefore considered necessary to pursue the screening of different extracts (compounds) of selected traditional medicinal plants reportedly having antidermatophyte potential. The aim of this study was to isolate and identify specific compound from the most active extract (free flavonoid) of stem of Terminalia chebula of the selected plants to treat dermatophytosis induced on experimental mice.

Singh, Geeta
Kumar, Padma
Joshi, Suresh Chandra
Publication Title: 
Biological & Pharmaceutical Bulletin

Candida albicans is one of the most prevalent human opportunistic pathogens. C. albicans undergoes a yeast-to-hyphal transition that has been identified as a virulence factor as well as a critical element for mature biofilm formation. A previous study in our lab showed retigeric acid B (RAB), a lichen derived pentacyclic triterpenoid, displayed synergistic antifungal activity with azoles. We now showed that this combination also proved to be adequate in combating the formation of hyphae in vitro.

Chang, Wenqiang
Li, Ying
Zhang, Li
Cheng, Aixia
Liu, Yongqing
Lou, Hongxiang
Publication Title: 
Scientific American
Stipp, David


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