Antigens, CD

Publication Title: 
Forschende Komplementarmedizin (2006)

BACKGROUND: To evaluate the evidence available on the effects of acupuncture point (acupoint) application for asthma therapy in adults. METHODS: Six electronic databases were searched up to May 2014 to identify relevant studies. Randomized controlled trials, which assessed the effects of acupoint application for asthma treatment in adults, were included in our review. The methodological quality of eligible studies was assessed by the Cochrane Collaboration's tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.

Author(s): 
Su, Li
Meng, Ling
Chen, Ran
Wu, Weihua
Peng, Bo
Man, Lixin
Publication Title: 
Biogerontology

The aim of the present study was to determine Toll-like receptor (TLR)-2 and TLR-4 membrane expression on the major peritoneal leukocyte populations throughout the aging process, including subjects that had achieved exceptional longevity. ICR (CD1) female mice of different ages: adult (44 +/- 4 weeks), old (69 +/- 4), very old (92 +/- 4) and extreme long-lived (125 +/- 4), were used.

Author(s): 
Arranz, Lorena
De Castro, Nuria M.
Baeza, Isabel
De la Fuente, MÛnica
Publication Title: 
Cell Proliferation

OBJECTIVES: This study has intended to investigate longevity of subcutaneous fat-derived mesenchymal stem cells (SF-MSCs) under extensive culturing. It has also focused on optimization of culture media for them over prolonged periods in vitro. MATERIALS AND METHODS: We evaluated SF-MSCs with reference to phenotypic characterization, proliferative ability, karyotype stability and differentiation potency with early (P3) and late passage (P20) conditions, using four different media, DMEM-LG, ALPHA-MEM, DMEM-F12 and DMEM-KO.

Author(s): 
Dhanasekaran, M.
Indumathi, S.
Rashmi, M.
Rajkumar, J. S.
Sudarsanam, D.
Publication Title: 
Nature

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin.

Author(s): 
Yilmaz, ÷mer H.
Katajisto, Pekka
Lamming, Dudley W.
G¸ltekin, Yetis
Bauer-Rowe, Khristian E.
Sengupta, Shomit
Birsoy, Kivanc
Dursun, Abdulmetin
Yilmaz, V. Onur
Selig, Martin
Nielsen, G. Petur
Mino-Kenudson, Mari
Zukerberg, Lawrence R.
Bhan, Atul K.
Deshpande, Vikram
Sabatini, David M.
Publication Title: 
Journal of Immunological Methods

Telomeres are the DNA-protein complexes that protect the ends of eukaryotic chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding telomeric DNA. A growing body of literature links shorter telomere length and lower telomerase activity with various age-related diseases and earlier mortality. Thus, leukocyte telomere length (LTL) and telomerase activity are emerging both as biomarkers and contributing factors for age-related diseases.

Author(s): 
Lin, Jue
Epel, Elissa
Cheon, Joshua
Kroenke, Candyce
Sinclair, Elizabeth
Bigos, Marty
Wolkowitz, Owen
Mellon, Synthia
Blackburn, Elizabeth
Publication Title: 
Journal of Immunological Methods

Telomeres are the DNA-protein complexes that protect the ends of eukaryotic chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding telomeric DNA. A growing body of literature links shorter telomere length and lower telomerase activity with various age-related diseases and earlier mortality. Thus, leukocyte telomere length (LTL) and telomerase activity are emerging both as biomarkers and contributing factors for age-related diseases.

Author(s): 
Lin, Jue
Epel, Elissa
Cheon, Joshua
Kroenke, Candyce
Sinclair, Elizabeth
Bigos, Marty
Wolkowitz, Owen
Mellon, Synthia
Blackburn, Elizabeth
Publication Title: 
Asian Pacific journal of cancer prevention: APJCP

Cytotoxic activity of artemisinin and derivatives in the presence and absence of holo-transferrin and expression of genes involved in resistance of cancer cells were investigated in human cholangiocarcinoma (CL-6) and hepatocarcinoma (Hep-G2) cell lines in vitro. After incubation with the test drugs and 5-fluorouracil (5-FU) cytotoxicity was asessed by MTT assay.

Author(s): 
Chaijaroenkul, Wanna
Viyanant, Vithoon
Mahavorasirikul, Wiratchanee
Na-Bangchang, Kesara
Publication Title: 
PloS One

Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models. Although iron mediated oxidative damage is involved, the mechanisms underlying these activities remain unclear. In the current study, we found that dihydroartemisinin caused cellular iron depletion in time- and concentration-dependent manners. It decreased iron uptake and disturbed iron homeostasis in cancer cells, which were independent of oxidative damage.

Author(s): 
Ba, Qian
Zhou, Naiyuan
Duan, Juan
Chen, Tao
Hao, Miao
Yang, Xinying
Li, Junyang
Yin, Jun
Chu, Ruiai
Wang, Hui
Publication Title: 
Neuro-Oncology

BACKGROUND: A proportion of glioblastoma stemlike cells (GSCs) expressing endothelial cell marker CDH5 (vascular-endothelial-cadherin or CD144) can transdifferentiate into endothelial cells and form blood vessels. However, the implications of CDH5 expression in gliomas and how it is regulated in GSCs remain to be clarified. METHODS: The mRNA and protein levels of CDH5 were detected in glioma samples and cultured cell lines, and the prognostic value of the CDH5 expression level for GBM patients was evaluated.

Author(s): 
Mao, Xing-Gang
Xue, Xiao-Yan
Wang, Liang
Zhang, Xiang
Yan, Ming
Tu, Yan-yang
Lin, Wei
Jiang, Xiao-Fan
Ren, Hong-Gang
Zhang, Wei
Song, Shao-Jun
Publication Title: 
Journal of Leukocyte Biology

Although the exact etiology of rheumatoid arthritis (RA) remains unknown, there is increasing evidence that reactive oxygen species and a pro-oxidant/antioxidant imbalance are an important part of the pathogenesis of joint tissue injury. Flow cytometry was used to evaluate the thiol status [surface-thiols and intracellular glutathione (iGSH)] of leukocytes from RA patients and controls. Levels of surface-thiols and iGSH of leukocytes from RA patients were significantly lower than of leukocytes from controls.

Author(s): 
Pedersen-Lane, Joan H.
Zurier, Robert B.
Lawrence, David A.

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