Antigens, CD11b

Publication Title: 
Phytotherapy research: PTR

Penta-O-galloyl-?-D-glucose (PGG) occurrs in high concentrations in medicinal herbs such as Rhus chinensis, Paeonia suffruticosa, Acer truncatum and Terminalia chebula, which demonstrate anti-inflammatory activity. We investigated the effect of PGG on stimulated and non-stimulated neutrophils in processes which included reactive oxygen species generation (ROS), metalloproteinase-9 and interleukin-8 secretion (IL-8), ?? integrin (CD11b) and L-selectin (CD62L) expression and apoptosis.

Author(s): 
Kiss, Anna K.
Filipek, Agnieszka
Zy?y?ska-Granica, Barbara
Naruszewicz, Marek
Publication Title: 
Circulation

BACKGROUND: Obesity is associated with chronic inflammation, which includes increased macrophage accumulation in adipose tissue (AT) and upregulation of chemokines and cytokines. T cells also play important roles in chronic inflammatory diseases such as atherosclerosis but have not been well studied in obesity. METHODS AND RESULTS: Flow cytometric analysis showed higher numbers of T cells and macrophages in AT of diet-induced obese insulin-resistant male mice than in lean mice and obese females (P<0.05).

Author(s): 
Wu, Huaizhu
Ghosh, Sudip
Perrard, Xiaoyuan Dai
Feng, Lili
Garcia, Gabriela E.
Perrard, Jerry L.
Sweeney, John F.
Peterson, Leif E.
Chan, Lawrence
Smith, C. Wayne
Ballantyne, Christie M.
Publication Title: 
Archives of Pathology & Laboratory Medicine

CONTEXT: Inflammation is pivotal to atherosclerosis. The monocyte-macrophage, a crucial cell in atherogenesis, is present during all stages of atherosclerosis. However, there is a paucity of data comparing circulating monocytes to cholesterol-laden macrophages (foam cells), with regard to their atherogenic properties, especially in subjects with established risk factors such as hyperlipidemia.

Author(s): 
Devaraj, Sridevi
Jialal, Ishwarlal
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Myeloid-derived suppressor cells (MDSCs) promote tumor progression. The mechanisms of MDSC development during tumor growth remain unknown. Tumor exosomes (T-exosomes) have been implicated to play a role in immune regulation, however the role of exosomes in the induction of MDSCs is unclear. Our previous work demonstrated that exosomes isolated from tumor cells are taken up by bone marrow myeloid cells. Here, we extend those findings showing that exosomes isolated from T-exosomes switch the differentiation pathway of these myeloid cells to the MDSC pathway (CD11b(+)Gr-1(+)).

Author(s): 
Xiang, Xiaoyu
Poliakov, Anton
Liu, Cunren
Liu, Yuelong
Deng, Zhong-Bin
Wang, Jianhua
Cheng, Ziqiang
Shah, Spandan V.
Wang, Gui-Jun
Zhang, Liming
Grizzle, William E.
Mobley, Jim
Zhang, Huang-Ge
Publication Title: 
Hepatology (Baltimore, Md.)

Chronic inflammation plays a critical role in promoting obesity-related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation. We found that the accumulation of immature myeloid cells, i.e., CD11b(+)Ly6C(hi)Ly6G(-) cells, in the liver of B6 mice fed a high-fat diet contribute to liver inflammation.

Author(s): 
Deng, Zhong-Bin
Liu, Yuelong
Liu, Cunren
Xiang, Xiaoyu
Wang, Jianhua
Cheng, Ziqiang
Shah, Spandan V.
Zhang, Shuangyin
Zhang, Liming
Zhuang, Xiaoying
Michalek, Sue
Grizzle, William E.
Zhang, Huang-Ge
Publication Title: 
European Journal of Immunology

Cannabinoid receptor activation by agents such as Δ(9)-tetrahydrocannabinol (THC) is known to trigger immune suppression. Here, we show that administration of THC in mice leads to rapid and massive expansion of CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSC) expressing functional arginase and exhibiting potent immunosuppressive properties both in vitro and in vivo. The induction of MDSC by THC was associated with a significant increase in granulocyte CSF. Moreover, administration of anti-granulocyte CSF Ab inhibited the induction of MDSC by THC.

Author(s): 
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
PloS One

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are getting increased attention as one of the main regulatory cells of the immune system. They are induced at sites of inflammation and can potently suppress T cell functions. In the current study, we demonstrate how activation of TRPV1 vanilloid receptors can trigger MDSCs, which in turn, can inhibit inflammation and hepatitis.

Author(s): 
Hegde, Venkatesh L.
Nagarkatti, Prakash S.
Nagarkatti, Mitzi
Publication Title: 
Brain, Behavior, and Immunity

Resveratrol, a naturally occurring polyphenol has received significant attention as a potent anti-inflammatory agent. Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by hyperactivated effector immune cells that produce proinflammatory cytokines. Myeloid derived suppressor cells (MDSCs) are a heterogeneous population characterized by the co-expression of CD11b(+) and Gr-1(+) and have long been known for their immunosuppressive function.

Author(s): 
Singh, Udai P.
Singh, Narendra P.
Singh, Balwan
Hofseth, Lorne J.
Taub, Dennis D.
Price, Robert L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Neurochemical Research

Microglial activation participates in the pathogenesis of various neuroinflammatory and neurodegenerative diseases. However, mechanisms by which microglial activation could be controlled are poorly understood. Peroxisome proliferator-activated receptors (PPAR) are transcription factors belonging to the nuclear receptor super family with diverse effect. This study underlines the importance of PPARβ/δ in mediating the anti-inflammatory effect of gemfibrozil, an FDA-approved lipid-lowering drug, in primary human microglia.

Author(s): 
Jana, Malabendu
Pahan, Kalipada
Publication Title: 
Microcirculation (New York, N.Y.: 1994)

OBJECTIVE: We sought to test the hypothesis that turmeric-derived curcuminoids limit reperfusion brain injury in an experimental model of stroke via blockade of early microvascular inflammation during reperfusion. METHODS: Male Sprague Dawley rats subjected to MCAO/R were treated with turmeric-derived curcuminoids (vs. vehicle) 1 hour prior to reperfusion (300 mg/kg ip).

Author(s): 
Funk, Janet L.
Frye, Jennifer B.
Davis-Gorman, Grace
Spera, Allison L.
Bernas, Michael J.
Witte, Marlys H.
Weinand, Martin E.
Timmermann, Barbaba N.
McDonagh, Paul F.
Ritter, Leslie

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