Antigens, Helminth

Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemether (Art) on the thio proteinase ("hemoglobinase", Hem) of Schistosoma japonicum. METHODS: Hem was extracted from S japonicum adults. The inhibitory effect of Art on the activity of Hem to degrade human hemoglobin (Hgb) was examined with UV-photometer at 280 nm, SDS-PAGE and scanning at 600 nm on a chromoscanner. RESULTS: Human Hgb was degraded at pH 4.0 by the Hem. The activities of Hem preincubated at 37 degrees C with Art 0.14, 1.4, and 14 mmol.L-1, were inhibited by 30.2%, 39.8%, and 45.0%, respectively.

Author(s): 
Gong, P. L.
Li, Y. L.
Feng, Y. R.
Publication Title: 
Journal of Biomedicine & Biotechnology

In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S.

Author(s): 
Xu, Xinyu
Wen, Xiaoyun
Chi, Ying
He, Lei
Zhou, Sha
Wang, Xuefeng
Zhao, Jiaqing
Liu, Feng
Su, Chuan
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