Antigens, Ly

Publication Title: 
Nature Communications

With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspan extension.

Lavasani, Mitra
Robinson, Andria R.
Lu, Aiping
Song, Minjung
Feduska, Joseph M.
Ahani, Bahar
Tilstra, Jeremy S.
Feldman, Chelsea H.
Robbins, Paul D.
Niedernhofer, Laura J.
Huard, Johnny
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Fish oil, containing omega-3 fatty acids, attenuates atherosclerosis. We hypothesized that omega-3 fatty acid-enriched oils are atheroprotective through alteration of monocyte subsets and their trafficking into atherosclerotic lesions. METHODS AND RESULTS: Low-density lipoprotein receptor knockout and apolipoprotein E(-/-) mice were fed diets containing 10% (calories) palm oil and 0.2% cholesterol, supplemented with an additional 10% palm oil, echium oil (containing 18:4 n-3), or fish oil.

Brown, Amanda L.
Zhu, Xuewei
Rong, Shunxing
Shewale, Swapnil
Seo, Jeongmin
Boudyguina, Elena
Gebre, Abraham K.
Alexander-Miller, Martha A.
Parks, John S.
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