Antimetabolites

Publication Title: 
Urological Research

Most of the drugs administered to stone patients appear to be inappropriate and doing more harm than good to the patients. The objective of this paper is to identify the prevalence of blind chemotherapy among the stone patients and find out the real indication for the drugs administered. Patients who attended the stone clinic for the first time were interviewed to find out what drugs they had been taking before the attendance at the stone clinic. 350 patients consuming specific drugs relevant to stone formation at least for a period of 15 days were selected for a detailed assessment.

Author(s): 
Fazil Marickar, Y. M.
Salim, Abiya
Vijay, Adarsh
Publication Title: 
Pancreas

OBJECTIVES: A new method of determining protein turnover by labeling protein with N amino acids was used in conjunction with serum-free cell culture to profile secreted proteins that are released by MIA PaCa-2 pancreatic cancer cells in culture. METHODS: MIA PaCa-2 cells were first cultured in Dulbecco modified Eagle medium (Gibco by Invitrogen, Carlsbad, Calif) with 10% fetal bovine serum, then in serum-free modified Eagle medium with or without 50% N algal amino acid mixture. The effect of oxythiamine chloride on secreteome was studied.

Author(s): 
Xiao, Jing
Lee, Wai-Nang Paul
Zhao, Yingchun
Cao, Rui
Go, Vay Liang W.
Recker, Robert R.
Wang, Qi
Xiao, Gary Guishan
Publication Title: 
Stroke; a Journal of Cerebral Circulation

BACKGROUND AND PURPOSE: Carbon monoxide (CO) is a gaseous second messenger produced when heme oxygenase enzymes catabolize heme. We have demonstrated that CO can be therapeutic in ischemia-reperfusion brain injury; however, it is unclear whether CO can also offer protection in permanent ischemic stroke or what mechanism(s) underlies the effect. Heme oxygenase-1 neuroprotection was shown to be regulated by Nrf2; therefore, we investigated whether CO might partially exert neuroprotection by modulating the Nrf2 pathway.

Author(s): 
Wang, Bing
Cao, Wangsen
Biswal, Shyam
Doré, Sylvain
Publication Title: 
International Braz J Urol: Official Journal of the Brazilian Society of Urology

INTRODUCTION: The exact mechanism of chronic nonbacterial prostatitis has not been yet elucidated and the outcome with the current management is dismal. In this trial, we studied the effect of allopurinol in the treatment of this disease. MATERIALS AND METHODS: In this randomized double blind controlled trial, a calculated sample size of 56 were grouped into "intervention group" who received allopurinol (100 mg tds for 3 months) with ofloxacin (200 mg tds) for 3 weeks (n = 29) and "control group" who received placebo tablets with ofloxacin (n = 27).

Author(s): 
Ziaee, Amir M.
Akhavizadegan, Hamed
Karbakhsh, Mojgan
Publication Title: 
Cancer Research

Dietary energy restriction (DER) is a potent inhibitor of carcinogenesis, but chronic DER in human populations is difficult to sustain. Consequently, interest exists in identifying energy restriction mimetic agents (ERMAs), agents that provide the health benefits of DER without reducing caloric intake. The selection of a candidate ERMAs for this study was based on evidence that DER inhibits carcinogenesis by limiting glucose availability. The study objective was to determine if 2-deoxyglucose (2-DG), a glucose analogue that blocks its metabolism, would inhibit mammary carcinogenesis.

Author(s): 
Zhu, Zongjian
Jiang, Weiqin
McGinley, John N.
Thompson, Henry J.
Publication Title: 
American Journal of Nephrology

BACKGROUND: Both ACE inhibitors and allopurinol have been shown to partially prevent metabolic syndrome induced by fructose. We tested the hypothesis that combined therapy might be more effective at blocking the metabolic syndrome induced with fructose. METHODS: Male Sprague-Dawley rats were fed a high fructose diet with or without allopurinol, captopril, or the combination for 20 weeks. A control group received a normal diet. All groups were pair-fed to assure equivalent caloric intake.

Author(s): 
Roncal, Carlos A.
Reungjui, Sirirat
Sánchez-Lozada, Laura Gabriela
Mu, Wei
Sautin, Yuri Y.
Nakagawa, Takahiko
Johnson, Richard J.
Publication Title: 
Acta Orthopaedica Et Traumatologica Turcica

OBJECTIVE: The aim of this study was to investigate the influence of the antiproliferative agent 5-Fluorouracil (5FU) over inhibition of spinal bone formation in an experimental rat model. METHODS: The study included 30 6-month-old Sprague-Dawley rats divided into 3 groups. Aggressive periosteal denuding was performed by scalpel to induce punctuate bleeding in the posterior elements of the L4-L5 vertebrae in the spontaneous fusion model. Spinous processes were fixated by wires and no graft substitute was applied. Adcon-L was applied in Group 1, single-touch technique 5FU in Group 2.

Author(s): 
Kıter, Esat
Er, Ertan
Sen Türk, Nilay
Oto, Murat
Akkaya, Semih
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