Antineoplastic Agents, Phytogenic

Publication Title: 
The Veterinary Clinics of North America. Small Animal Practice

Integrative medicine is the combined use of complementary and alternative medicine with conventional or traditional Western medicine systems. The demand for integrative veterinary medicine is growing, but evidence-based research on its efficacy is limited. In veterinary clinical oncology, such research could be translated to human medicine, because veterinary patients with spontaneous tumors are valuable translational models for human cancers.

Author(s): 
Raditic, Donna M.
Bartges, Joseph W.
Publication Title: 
European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences

Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone) is a biologically active alkaloid/amide from peppers, as from long pepper (Piper longum L. - Piperaceae). Long pepper is one of the most widely used in Ayurvedic medicine, which is used to treat many diseases, including tumors.

Author(s): 
Bezerra, Daniel P.
Pessoa, Claudia
de Moraes, Manoel O.
Saker-Neto, Nicolau
Silveira, Edilberto R.
Costa-Lotufo, Leticia V.
Publication Title: 
Journal of Ethnopharmacology

A 70% methanol extract of Terminalia chebula fruit, was studied for its effects on growth in several malignant cell lines including a human (MCF-7) and mouse (S115) breast cancer cell line, a human osteosarcoma cell line (HOS-1), a human prostate cancer cell line (PC-3) and a non-tumorigenic, immortalized human prostate cell line (PNT1A) using assays for proliferation ([(3)H]-thymidine incorporation and coulter counting), cell viability (ATP determination) and cell death (flow cytometry and Hoechst DNA staining).

Author(s): 
Saleem, Ammar
Husheem, Michael
Härkönen, Pirkko
Pihlaja, Kalevi
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Triphala (Sanskrit tri?=?three and phala?=?fruits), composed of the three medicinal fruits Phyllanthus emblica L. or Emblica officinalis Gaertn., Terminalia chebula Retz., and Terminalia belerica Retz. is an important herbal preparation in the traditional Indian system of medicine, Ayurveda. Triphala is an antioxidant-rich herbal formulation and possesses diverse beneficial properties. It is a widely prescribed Ayurvedic drug and is used as a colon cleanser, digestive, diuretic, and laxative.

Author(s): 
Baliga, Manjeshwar Shrinath
Publication Title: 
Journal of Medicinal Food

Terminalia chebula is a native plant from southern Asia to southwestern China that is used in traditional medicine for the treatment of malignant tumors and diabetes. This plant also has antibacterial and immunomodulatory properties. The present study assessed T. chebula extract-dependent protein expression changes in Jurkat cells. Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and Ingenuity Pathways Analysis (IPA) were performed to assess protein expression and networks, respectively. A comparative proteomic profile was determined in T.

Author(s): 
Das, Nando Dulal
Jung, Kyoung Hwa
Park, Ji Hyun
Choi, Mi Ran
Lee, Hyung Tae
Kim, Moo Sung
Lee, Sang Rin
Chai, Young Gyu
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Breast cancer is the most common cancer diagnosed among women and is the second leading cause of cancer death. Homeopathic medicines are part of the alternative medicines that are given as a supportive therapy in breast cancer. The objective of this study was to investigate the anticancer activity of commercially available homeopathic preparations of Terminalia chebula (TC) and evaluate their nanoparticulate nature.

Author(s): 
Wani, Kirtee
Shah, Nilesh
Prabhune, Asmita
Jadhav, Arun
Ranjekar, Prabhakar
Kaul-Ghanekar, Ruchika
Publication Title: 
Cancer Chemotherapy and Pharmacology

PURPOSE: Chemoneuropathy remains a painful, burdensome complication of cancer treatment for patients receiving a range of chemotherapeutics, yet the cause and persistence of this condition are not fully documented. This study was designed to quantify the longevity of and contributions to neuropathy following treatment with the plant alkaloids paclitaxel and vincristine.

Author(s): 
Boyette-Davis, Jessica A.
Cata, Juan P.
Driver, Larry C.
Novy, Diane M.
Bruel, Brian M.
Mooring, Deidre L.
Wendelschafer-Crabb, Gwen
Kennedy, William R.
Dougherty, Patrick M.
Publication Title: 
Cell Death & Disease

Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro and in Caenorhabditis elegans in vivo. The knockdown or knockout of Sirtuin-1 prevented the induction of autophagy by resveratrol and by nutrient deprivation in human cells as well as by dietary restriction in C. elegans.

Author(s): 
Morselli, E.
Maiuri, M. C.
Markaki, M.
Megalou, E.
Pasparaki, A.
Palikaras, K.
Criollo, A.
Galluzzi, L.
Malik, S. A.
Vitale, I.
Michaud, M.
Madeo, F.
Tavernarakis, N.
Kroemer, G.
Publication Title: 
Journal of Natural Products

Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico.

Author(s): 
León-Rivera, Ismael
Mirón-López, Gumersindo
Molina-Salinas, Gloria María
Herrera-Ruiz, Maribel
Estrada-Soto, Samuel
del Carmen Gutiérrez, María
Alonso-Cortes, Daniel
Navarrete-Vázquez, Gabriel
Rios, María Yolanda
Said-Fernández, Salvador
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The cytotoxicities of 2 derivatives of artemisinin B and 2 derivatives of artemisic acid (designated as Compound A, B, C, and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 micrograms.ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%.

Author(s): 
Sun, W. C.
Han, J. X.
Yang, W. Y.
Deng, D. A.
Yue, X. F.

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