Antipsychotic Agents

Publication Title: 
The Journal of Clinical Psychiatry

OBJECTIVE: To review the evidence for treating anxiety in patients with bipolar disorder. DATA SOURCES: A literature search from 1950 to week 1 of August 2009 was conducted via OVID and the National Institutes of Health's clinical trials online databases. Search terms included anxiety, anxiety disorders, bipolar disorder, panic disorder, generalized anxiety disorder, social phobia, social anxiety, obsessive compulsive disorder, specific phobia, posttraumatic stress disorder, and treatment. Reference lists of identified articles were also searched.

Author(s): 
Rakofsky, Jeffrey J.
Dunlop, Boadie W.
Publication Title: 
CNS drugs

Evidence-based medicine (EBM) is a broad concept, but the key elements include the incorporation of clinical judgment (which requires clinical experience) together with relevant scientific evidence while remaining mindful of the individual patient's values and preferences.

Author(s): 
Citrome, Leslie
Publication Title: 
International Journal of Clinical Practice

BACKGROUND: Acupuncture is one of the most popular types of complementary/alternative medicine. It is sometimes used as a treatment for schizophrenia. AIMS: The objective of this review is to assess systematically the clinical evidence for or against acupuncture as a treatment for schizophrenia. METHODS: We searched 20 databases from their inception to May 2009 without language restrictions. All randomised clinical trials (RCTs) of acupuncture, with or without electrical stimulation or moxibustion for patients with schizophrenia were considered for inclusion.

Author(s): 
Lee, M. S.
Shin, B.-C.
Ronan, P.
Ernst, E.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Antipsychotic-related constipation is a common and serious adverse effect, especially for people taking clozapine. Clozapine has been shown to impede gastrointestinal motility, leading to constipation, and has been reported in up to 60% of patients receiving clozapine. In rare cases, complications can be fatal. Appropriate laxatives should be prescribed to treat constipation in people taking antipsychotics, but there is a lack of guidance on the comparative effectiveness and harms of different agents in this population.

Author(s): 
Every-Palmer, Susanna
Newton-Howes, Giles
Clarke, Mike J.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Acupuncture, with many categories such as traditional acupuncture, electroacupuncture, laser acupuncture, and acupoint injection, has been shown to be relatively safe with few adverse effects. It is accessible and inexpensive, at least in China, and is likely to be widely used there for psychotic symptoms. OBJECTIVES: To review the effects of acupuncture, alone or in combination treatments compared with placebo (or no treatment) or any other treatments for people with schizophrenia or related psychoses.

Author(s): 
Shen, Xiaohong
Xia, Jun
Adams, Clive E.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Ayurvedic medicine has been used to treat mental health problems since 1000 BC. OBJECTIVES: To review effects of Ayurvedic medicine or treatments for schizophrenia. SEARCH STRATEGY: We searched the Cochrane Schizophrenia Group Trials Register (March 2007) and AMED (March 2007), inspected references of all identified studies and contacted the first author of each included study.

Author(s): 
Agarwal, V.
Abhijnhan, A.
Raviraj, P.
Publication Title: 
Nature
Author(s): 
Anthes, Emily
Publication Title: 
Praxis

The Gilles de la Tourette syndrome is a usually chronic neuropsychiatric disorder with an early childhood onset featuring mainly motor and vocal tics. It seems that strong genetic factors make a major contribution to the etiology of this disorder, but there are also clues that epigenetic factors are involved in the pathogenesis of Tourette's syndrome, such as maternal stress during pregnancy, birth complications and hormonal influences.

Author(s): 
Knecht, T.
Publication Title: 
Current Opinion in Pharmacology

Neurochemical and structural prefrontal cortex abnormalities, including decreased reelin and glutamic acid decarboxylase (GAD)(67) expression, decreased thickness, increased neuronal packing density and decreased neuropil and dendritic spine number, are characteristics of schizophrenia neuropathology. Reelin is an extracellular matrix protein secreted by GABAergic interneurons that, acting through pyramidal neuron integrin receptors, provides a signal for dendritic spine plasticity.

Author(s): 
Costa, Erminio
Davis, John
Pesold, Christine
Tueting, Patricia
Guidotti, Alessandro
Publication Title: 
Critical Reviews in Neurobiology

Several lines of evidence support the role of an epigenetic-induced GABAergic cortical dysfunction in schizophrenia psychopathology, which is probably dependent on an increase in the expression of DNA-methyltransferase-1 occurring selectively in GABAergic neurons. The key enzyme regulating GABA synthesis, termed glutamic acid decarboxylase 67 (GAD67) and the important neurodevelopmental protein called reelin are coexpressed in GABAergic neurons. Upon release, GABA and reelin bind to postsynaptic receptors located in dendrites, somata, or the axon initial segment of pyramidal neurons.

Author(s): 
Costa, E.
Davis, J. M.
Dong, E.
Grayson, D. R.
Guidotti, A.
Tremolizzo, L.
Veldic, M.

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