Antiviral Agents

Publication Title: 
Respiratory Medicine

BACKGROUND: Many options are available for preventing people from getting infected by influenza virus, with vaccination being the most widely used. METHODS: We assessed the evidence available in Cochrane systematic reviews. We found nine reviews, five of them addressing influenza vaccination, and four addressing medication. RESULTS: Vaccination is effective in healthy adults and children, but the effect is modest in adults, and for young children few data are available.

van der Wouden, J. C.
Bueving, H. J.
Poole, P.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

This review presents a critical evaluation of methodological quality in controlled trials on homeopathic treatment of influenza. First, a short summary on the prevalence, quality, and most commonly cited shortcomings of homeopathic controlled trials in general is presented to support the more specific points within influenza trials alone.

Kirkby, R.
Herscu, P.
Publication Title: 
Laryngo- Rhino- Otologie

A new S2k AWMF guideline for the treatment of idiopathic facial palsy has been published. An accurate differential diagnosis is indispensable as 25-40% of all facial palsy cases are of non-idiopathic origin. It is explicitly recommended to treat patients with idiopathic facial palsy with steroids. Steroids favour a complete recovery, decrease the risk of synkinesis, autonomic sequelae and contractures. Adjuvant antiviral therapy cannot be recommended. On current data there is not sufficient evidence that the combination of steroids with antiviral drugs has a benefit for the patients.

Heckmann, J. G.
Lang, C.
Glocker, F. X.
Urban, P.
Bischoff, C.
Weder, B.
Reiter, G.
Meier, U.
Guntinas-Lichius, O.
Association of the Scientific Medical Societies in Germany (AWMF)
Publication Title: 
Phytotherapy research: PTR

The antiviral effects of aqueous extracts of Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq. and Rheum palmatum L. were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8-day treatment.

Kim, T. G.
Kang, S. Y.
Jung, K. K.
Kang, J. H.
Lee, E.
Han, H. M.
Kim, S. H.
Publication Title: 
Teratogenesis, Carcinogenesis, and Mutagenesis

India is one of the 12 mega diversity countries in the world so it has a vital stake in conservation and sustainable utilization of its biodiversity resources. Plant secondary metabolites have been of interest to man for a long time due to their pharmacological relevance. With this in view, the bark powder of Acacia auriculiformis, A. nilotica, Juglans regia, and the fruit powder of Terminalia bellerica, T. chebula, Emblica officinalis, and a combination drug "Triphala," which are known to be rich in polyphenols, were tested for their antimutagenic activities.

Arora, Saroj
Kaur, Kamaljit
Kaur, Swayamjot
Publication Title: 
Journal of Virology

Herpes simplex virus 1 (HSV-1) is a common human pathogen that causes lifelong latent infection of sensory neurons. Non-nucleoside inhibitors that can limit HSV-1 recurrence are particularly useful in treating immunocompromised individuals or cases of emerging acyclovir-resistant strains of herpesvirus. We report that chebulagic acid (CHLA) and punicalagin (PUG), two hydrolyzable tannins isolated from the dried fruits of Terminalia chebula Retz. (Combretaceae), inhibit HSV-1 entry at noncytotoxic doses in A549 human lung cells.

Lin, Liang-Tzung
Chen, Ting-Ying
Chung, Chueh-Yao
Noyce, Ryan S.
Grindley, T. Bruce
McCormick, Craig
Lin, Ta-Chen
Wang, Guey-Horng
Lin, Chun-Ching
Richardson, Christopher D.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The herb formulation Deva-5 is used in traditional medicine to treat acute infectious diseases. Deva-5 is composed of five herbs: Gentiana decumbens L., Momordica cochinchinensis L., Hypecoum erectum L., Polygonum bistorta L., and Terminalia chebula Retz. Deva-5 and its five components were investigated for in vitro antiviral activity against avian influenza A virus subtype H3N8. METHODS: The water extracts of the herbal parts of G. decumbens, H. erectum and P. bistorta, the seeds of T. chebula and M.

Oyuntsetseg, Namsrai
Khasnatinov, Maxim A.
Molor-Erdene, Perenlei
Oyunbileg, Janchiv
Liapunov, Aleksander V.
Danchinova, Galina A.
Oldokh, Sanduijav
Baigalmaa, Jigden
Chimedragchaa, Chimedtseren
Publication Title: 

Two new hydrolysable tannins, chebumeinin A (1) and chebumeinin B (2), together with eight known related compounds (3-10), were isolated from the fruits of Terminalia chebula. The new compounds were structurally determined by analysis of their spectroscopic data and the known compounds characterized by comparing their spectroscopic data with literature values. All isolates were evaluated by an HCV protease inhibition assay, and some compounds were found to be potently active.

Ajala, Olusegun S.
Jukov, Azzaya
Ma, Chao-Mei
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medicinal plants, in the present study, the potential of Terminalia chebula Retz was investigated for its activity against HSV-2. METHODS: Fruits of Terminalia chebula Retz were used to prepare 50% ethanolic extract. In addition, chebulagic acid and chebulinic acid both purified from T. chebula were also used.

Kesharwani, Ajay
Polachira, Suja Kizhiyedath
Nair, Reshmi
Agarwal, Aakanksha
Mishra, Nripendra Nath
Gupta, Satish Kumar
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

The French paradox is a dietary anomaly which has focused attention on the Mediterranean diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium and Brassica vegetables, and red wine), correlated with the increased longevity and decreased incidence of cardiovascular disease seen in these populations. The most frequently studied flavonoid, quercetin, has been shown to have biological properties consistent with its sparing effect on the cardiovascular system.

Formica, J. V.
Regelson, W.


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