Aorta

Publication Title: 
International Journal of Cardiology

Four groups of 25 rabbits each, were studied to determine the effect of Haritaki (Terminalia chebula), Amla (Emblica officinalis) and Bahira (Terminalia belerica) on cholesterol-induced hypercholesteolaemia and atherosclerosis. The control group was fed with cholesterol alone; the Haritaki group received Haritaki and cholesterol; the Bahira group received Bahira and cholesterol; and the Amla group received Amla and cholesterol for 16 weeks.

Author(s): 
Thakur, C. P.
Thakur, B.
Singh, S.
Sinha, P. K.
Sinha, S. K.
Publication Title: 
The Journal of Clinical Investigation

Children conceived by assisted reproductive technologies (ART) display a level of vascular dysfunction similar to that seen in children of mothers with preeclamspia. The long-term consequences of ART-associated vascular disorders are unknown and difficult to investigate in healthy children. Here, we found that vasculature from mice generated by ART display endothelial dysfunction and increased stiffness, which translated into arterial hypertension in vivo. Progeny of male ART mice also exhibited vascular dysfunction, suggesting underlying epigenetic modifications.

Author(s): 
Rexhaj, Emrush
Paoloni-Giacobino, Ariane
Rimoldi, Stefano F.
Fuster, Daniel G.
Anderegg, Manuel
Somm, Emmanuel
Bouillet, Elisa
Allemann, Yves
Sartori, Claudio
Scherrer, Urs
Publication Title: 
Journal of Korean Academy of Nursing

PURPOSE: To investigate the effectiveness of aromatherapy on blood pressure, heart rate variability, aortic pulse wave velocity and the aortic augmentation index of essential hypertensive patients. METHODS: Using a coin toss, 22 participants were assigned to the experimental group and 20 to the control. The experimental group was given a blend of oils of lemon (Citrus limonum), lavender (Lavandula angustifolia), and ylang ylang (Cananga odorata) which were prepared in the ratio of 2:2:1, respectively.

Author(s): 
Cha, Jung Hee
Lee, Sun Hee
Yoo, Yang Sook
Publication Title: 
International Journal of Cardiology

Four groups of 25 rabbits each, were studied to determine the effect of Haritaki (Terminalia chebula), Amla (Emblica officinalis) and Bahira (Terminalia belerica) on cholesterol-induced hypercholesteolaemia and atherosclerosis. The control group was fed with cholesterol alone; the Haritaki group received Haritaki and cholesterol; the Bahira group received Bahira and cholesterol; and the Amla group received Amla and cholesterol for 16 weeks.

Author(s): 
Thakur, C. P.
Thakur, B.
Singh, S.
Sinha, P. K.
Sinha, S. K.
Publication Title: 
Clinical and Experimental Pharmacology & Physiology

1. The effects of Coccinia indica, an indigenous plant used in Ayurvedic medicine in India, on aortic collagen content and its characteristics were assessed in streptozotocin (STZ) diabetic rats. 2. Rats were made diabetic with a single intraperitoneal injection of STZ (45 mg/kg). Blood glucose, hydroxyproline, collagen, extent of glycation, collagen-linked fluorescence, soluble pattern of pepsin-soluble collagen, shrinkage temperature, alpha/beta ratio of type I collagen and type I/type III collagen ratio were determined in rats treated with C.

Author(s): 
Venkateswaran, Subramanian
Pari, Leelavinothan
Suguna, Lonchin
Chandrakasan, Gowri
Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVES: Inula racemosa Hook. f. is indicated for precordial chest pain in Ayurveda. In this study, the effects of a hexane (IrH) and an alcohol extract (IrA) of Inula racemosa on atherosclerosis induced by a high-fat diet in guinea-pigs were investigated. METHODS: After 30 days on a high-fat diet (guinea-pig pellet diet + 0.2% w/w cholesterol) six animals were killed and evaluated for the onset of early atherosclerotic changes in coronary artery, aorta and major organs.

Author(s): 
Mangathayaru, Kalachaveedu
Kuruvilla, Sarah
Balakrishna, Kedike
Venkhatesh, Jayakothandaramaswamy
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia arjuna - stem bark extract is traditionally used as cardiotonic in Ayurvedic medicine. AIM OF THE STUDY: The present study was aimed to evaluate the molecular basis for cardioprotective potential of Terminalia arjuna (TA) stem bark, using cell cultures of human monocytic (THP-1) and human aortic endothelial cells (HAECs).

Author(s): 
Kokkiripati, Praveen K.
Kamsala, Ratnam V.
Bashyam, Leena
Manthapuram, Nalini
Bitla, Prasanth
Peddada, Vidyadhari
Raghavendra, Agepati S.
Tetali, Sarada D.
Publication Title: 
Circulation

BACKGROUND: C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis. METHODS AND RESULTS: We tested the effect of CRP on eNOS expression and bioactivity in cultured human aortic endothelial cells (HAECs). CRP decreased eNOS mRNA, protein abundance, and enzyme activity in HAECs. Furthermore, eNOS bioactivity assayed by cyclic GMP levels was significantly reduced by CRP.

Author(s): 
Venugopal, Senthil Kumar
Devaraj, Sridevi
Yuhanna, Ivan
Shaul, Philip
Jialal, Ishwarlal
Publication Title: 
Circulation

BACKGROUND: Inflammation plays a pivotal role in atherosclerosis. In addition to being a risk marker for cardiovascular disease, much recent data suggest that C-reactive protein (CRP) promotes atherogenesis via effects on monocytes and endothelial cells. The metabolic syndrome is associated with significantly elevated levels of CRP. Plasminogen activator inhibitor-1 (PAI-1), a marker of atherothrombosis, is also elevated in the metabolic syndrome and in diabetes, and endothelial cells are the major source of PAI-1.

Author(s): 
Devaraj, Sridevi
Xu, Dan Yan
Jialal, Ishwarlal
Publication Title: 
Circulation

BACKGROUND: In addition to being a risk marker for cardiovascular disease, much recent data suggest that C-reactive protein (CRP) promotes atherogenesis. Decreased endothelial NO and prostacyclin (PGI2) contribute to a proatherogenic and prothrombotic state. We have shown that CRP decreases endothelial NO synthase expression and bioactivity in human aortic endothelial cells (HAECs). PGI2 is a potent vasodilator and inhibitor of platelet aggregation. Hence, the aim of this study was to examine the effect of CRP on PGI2 release from HAECs and human coronary artery endothelial cells (HCAECs).

Author(s): 
Venugopal, Senthil Kumar
Devaraj, Sridevi
Jialal, Ishwarlal

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