The effect of orally administered indigenous drugs Terminalia arjuna, T. belerica and T. chebula were investigated on experimental atherosclerosis. Rabbits were fed a cholesterol-rich diet to induce atherosclerosis. The three drugs were fed along with cholesterol. At the end of the experimental period the animals were killed and their plasma and tissue lipid components estimated. Atherosclerotic lesions of the aorta were examined histologically. T. arjuna was found to be the most potent hypolipidemic agent and induced partial inhibition of rabbit atheroma. The results indicate that T.
American Journal of Physiology. Heart and Circulatory Physiology
We hypothesized that elevated partial pressures of O(2) would increase perivascular nitric oxide (*NO) synthesis. Rodents with O(2)- and.NO-specific microelectrodes implanted adjacent to the abdominal aorta were exposed to O(2) at partial pressures from 0.2 to 2.8 atmospheres absolute (ATA). Exposures to 2.0 and 2.8 ATA O(2) stimulated neuronal (type I) NO synthase (nNOS) and significantly increased steady-state.NO concentration, but the mechanism for enzyme activation differed at each partial pressure.
Journal of Manipulative and Physiological Therapeutics
Two reports are given of patients presenting to a chiropractic physician's office with the chief complaint of low back pain. Both patients' conditions were ultimately diagnosed as abdominal aortic aneurysms. These two reports demonstrate the importance of listening to a patient's case history, as well as the need for a thorough physical examination by the use of diagnostic tools. A brief review of the anatomy and clinical presentation is also presented.
A 44-year-old man with an acute aortic occlusion after chiropractic manipulation was found to have a lumbar artery aneurysm. This article presents a previously undescribed entity, a lumbar artery aneurysm, which manifested as a unique cause of distal aortic occlusion in a patient with chronic back pain.
Over-degradation of extracellular components by matrix metalloproteinases (MMPs) has been implicated as an important characteristic during the pathological evolution of the abdominal aortic aneurysm (AAA) and cerebral aneurysm (CA), which contribute to progressive dilation of vascular wall. However, mRNA and protein expression of local rennin-angiotensin system (RAS) components are found down-regulated in CA walls, which is contrary to long-holding concept that local RAS will be activated in response to increased hemodynamic stress and contributes to thickening of arterial wall.