Arginine

Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Aktuelle Urologie

The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder. New suggestions for definitions and nomenclature take this into consideration. Since aetiology and pathogenesis are still unknown a treatment of the cause is still not possible. There are neither evidence-based treatment algorithms nor a so-called standard therapy. Numerous therapeutic approaches have been tried up to now. These attempts can be divided into oral, intravesical, surgical and physical procedures.

Author(s): 
Binder, I.
Rossbach, G.
van Ophoven, A.
Publication Title: 
Canadian Journal of Physiology and Pharmacology

Padma 28 is a mixture of herbs used in traditional Tibetan medicine with anti-inflammatory activities. We investigated the effects of Padma 28 on nitric oxide (NO) production by the inducible nitric oxide synthase (iNOS) in lipopolysaccharide stimulated mouse macrophages (RAW 264.7). Padma 28 (0-900 microg/mL) induced a concentration dependent inhibition of inducible nitric oxide synthesis. iNOS protein expression showed a concentration dependent reduction as revealed by immunoblotting when cells were incubated with increasing amounts of Padma 28.

Author(s): 
Moeslinger, T.
Friedl, R.
Volf, I.
Brunner, M.
Koller, E.
Spieckermann, P. G.
Publication Title: 
Natural Product Research

This study was carried out to evaluate the possible efflux-pump inhibitory activity of a gallotannin 1,2,6-tri-O-galloyl-?-D-glucopyranose isolated from Terminalia chebula fruit against multidrug-resistant (MDR) uropathogenic Escherichia coli. Susceptibility tests of antibiotics and ethidium bromide in the presence and absence of isolated gallotannin and phenylalanine-arginine ?-naphthylamide (PA?N) were conducted by using the microbroth dilution assay.

Author(s): 
Bag, Anwesa
Chattopadhyay, Rabi Ranjan
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production. The latter may be linked to the availability of citrulline, which is the immediate precursor of arginine and limiting factor for de novo arginine production. Arginine metabolism is highly compartmentalized due to the expression of the enzymes involved in arginine metabolism in various organs. A small fraction of arginine enters the NO synthase (NOS) pathway. Tetrahydrobiopterin (BH4) is an essential and rate-limiting cofactor for the production of NO.

Author(s): 
Luiking, Yvette C.
Ten Have, Gabriella A. M.
Wolfe, Robert R.
Deutz, Nicolaas E. P.
Publication Title: 
Critical Reviews in Immunology

The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes cell proliferation and tissue repair. Remarkably, the molecules primarily responsible for these "Fight" (NO) or "Fix" (Ornithine) activities both arise from arginine, and via enzymatic pathways (iNOS and arginase) that down regulate each other.

Author(s): 
Mills, Charles D.
Publication Title: 
Journal of Agricultural and Food Chemistry
Author(s): 
Visek, W. J.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

A fundamental question in the basic biology of aging is whether there is a universal aging process. If indeed such a process exists, one would expect that it develops at a higher rate in short- versus long-lived species. We have quantitated pentosidine, a marker of glycoxidative stress in skin collagen from eight mammalian species as a function of age. A curvilinear increase was modeled for all species, and the rate of increase correlated inversely with maximum life-span.

Author(s): 
Sell, D. R.
Lane, M. A.
Johnson, W. A.
Masoro, E. J.
Mock, O. B.
Reiser, K. M.
Fogarty, J. F.
Cutler, R. G.
Ingram, D. K.
Roth, G. S.
Monnier, V. M.
Publication Title: 
Current Opinion in Clinical Nutrition and Metabolic Care

PURPOSE OF REVIEW: The purpose of this review is to highlight recent publications examining nitric oxide production in health and disease and its association with clinical nutrition and alterations in metabolism. RECENT FINDINGS: The role of the cofactor tetrahydrobiopterin in nitric oxide production and its relation with arginine availability is indicated as an important explanation for the arginine paradox. This offers potential for nitric oxide regulation by dietary factors such as arginine or its precursors and vitamin C.

Author(s): 
Luiking, Yvette C.
Engelen, MariÎlle P. K. J.
Deutz, Nicolaas E. P.
Publication Title: 
Medical Hypotheses

In addition to general lifestyle, a number of foods and dietary patterns, such as the Mediterranean diet (MD), are associated with lower incidences of chronic, age-related diseases, and mortality. We have shown that increased polyamine intake decreases age-associated pathology and increases longevity in mice. Several foods in the MD, such as fruits and legumes, are foods containing high amount of polyamines. Among age-associated conditions, cardiovascular diseases (CVD) are the leading cause of mortality worldwide, and individuals who adhere to a MD have a lower incidence of CVD.

Author(s): 
Soda, Kuniyasu

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