Aromatase

Publication Title: 
Cancer Research

In breast cancer, in situ estrogen production has been demonstrated to play a major role in promoting tumor growth. Aromatase is the enzyme responsible for the conversion of androgen substrates into estrogens. This enzyme is highly expressed in breast cancer tissue compared with normal breast tissue. A wine extract fraction was recently isolated from red wine that exhibited a potent inhibitory action on aromatase activity.

Author(s): 
Eng, Elizabeth T.
Ye, JingJing
Williams, Dudley
Phung, Sheryl
Moore, Roger E.
Young, Mary K.
Gruntmanis, Ugis
Braunstein, Glenn
Chen, Shiuan
Publication Title: 
Biology of Reproduction

Although alcoholism causes changes in hepatic folate metabolism that are aggravated by folate deficiency, male reproductive effects have never been studied. We evaluated changes in folate metabolism in the male reproductive system following chronic ethanol consumption and folate deficiency. Twenty-four juvenile micropigs received folate-sufficient (FS) or folate-depleted (FD) diets or the same diets containing 40% of energy as ethanol (FSE or FDE) for 14 wk, and the differences between the groups were determined by ANOVA.

Author(s): 
Wallock-Montelius, Lynn M.
Villanueva, Jesus A.
Chapin, Robert E.
Conley, A. J.
Nguyen, Hung P.
Ames, Bruce N.
Halsted, Charles H.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Estrogen (E2) is reported to regulate skeletal muscle mass and contractile function; whether E2 exerts its effects through estrogen receptor-alpha (ERalpha) or -beta (ERbeta) is unclear. We determined the effect of ERalpha or ERbeta elimination on muscle mass and contractile function in multiple muscles of the lower limb, muscles with different locomotor tasks and proportions of fiber types I and II: soleus (Sol), plantaris (Plan), tibialis anterior (TA), and gastrocnemius (Gast) in mature female mice.

Author(s): 
Brown, Marybeth
Ning, Jie
Ferreira, J. Andries
Bogener, Jennifer L.
Lubahn, Dennis B.
Publication Title: 
Breast cancer research: BCR

INTRODUCTION: Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms in CYP19A1, the final enzyme in estrogen synthesis, may be associated with the occurrence of AIAA. METHODS: We performed a cross-sectional study of postmenopausal women with stage 0 to III breast cancer receiving adjuvant aromatase inhibitor (AI) therapy. Patient-reported AIAA was the primary outcome.

Author(s): 
Mao, Jun J.
Su, H. Irene
Feng, Rui
Donelson, Michelle L.
Aplenc, Richard
Rebbeck, Timothy R.
Stanczyk, Frank
DeMichele, Angela
Publication Title: 
Asian Journal of Andrology

AIM: To examine the effects on rat aging of caloric restriction (CR1) and undernutrition (CR2) on the body and on testicular weights, on two enzymatic antioxidants (superoxide dismutase and catalase), on lipid peroxidation and on the expression of testicular aromatase and estrogen receptors (ER). METHODS: CR was initiated in 1-month-old rats and carried on until the age of 18 months.

Author(s): 
Hamden, Khaled
Silandre, Dorothee
Delalande, Christelle
El Feki, Abdefattah
Carreau, Serge
Publication Title: 
Asian Journal of Andrology

AIM: To investigate the effects of 17beta-estradiol (E2), Peganum harmala extract (PHE) and caloric restriction (CR) on various testis parameters during aging. METHODS: Twelve month-old male rats were treated for 6 months with either E2 or PHE, or submitted to CR (40%). RESULTS: Our results show that estrogens and CR are able to protect the male gonad by preventing the decrease of testosterone and E2 levels as well as the decrease of aromatase and estrogen receptor gene expressions.

Author(s): 
Hamden, Khaled
Silandre, Dorothee
Delalande, Christelle
Elfeki, Abdelfattah
Carreau, Serge
Publication Title: 
Cancer Prevention Research (Philadelphia, Pa.)

Obesity is a risk factor for the development of hormone receptor-positive breast cancer in postmenopausal women. Estrogen synthesis is catalyzed by aromatase. Recently, we identified an obesity→inflammation→aromatase axis in mouse models and women. In mouse models of obesity, inflammatory foci characterized by crown-like structures (CLS) consisting of dead adipocytes encircled by macrophages were found in the mammary gland. CLS of the breast were found in most overweight and obese women.

Author(s): 
Bhardwaj, Priya
Du, Baoheng
Zhou, Xi Kathy
Sue, Erika
Harbus, Michael D.
Falcone, Domenick J.
Giri, Dilip
Hudis, Clifford A.
Kopelovich, Levy
Subbaramaiah, Kotha
Dannenberg, Andrew J.
Publication Title: 
PloS One

BACKGROUND: Puerarin is a major isoflavonoid compound extracted from Radix puerariae. It has a weak estrogenic action by binding to estrogen receptors (ERs). In our early clinical practice to treat endometriosis, a better therapeutic effect was achieved if the formula of traditional Chinese medicine included Radix puerariae. The genomic and non-genomic effects of puerarin were studied in our Lab.

Author(s): 
Cheng, Wen
Chen, Lizao
Yang, Shengsheng
Han, Jie
Zhai, Dongxia
Ni, Jian
Yu, Chaoqin
Cai, Zailong
Publication Title: 
Reproductive biology and endocrinology: RB&E

BACKGROUND: Repeated electroacupuncture (EA) stimulation is known to stimulate the activity of the hypothalamus-pituitary-adrenal axis, and to enhance the circulation level of estrogen in the ovariectomized rats. To explore the source of the increased circulation estrogen, the extragonadal aromatization was detected. METHODS: Female rats were divided into five groups: 1) intact (INT), 2) intact with EA in specific points (INT+EA), 3) ovariectomized (OVX), 4) ovariectomized with EA in specific points (OVX+EA) and 5) ovariectomized with EA in non-specific points (OVX+C).

Author(s): 
Zhao, Hong
Tian, Zhanzhuang
Cheng, Lina
Chen, Boying
Publication Title: 
Reproductive biology and endocrinology: RB&E

BACKGROUND: The circulating estrogen concentration elevated gradually along with time after ovariectomy in rats. To explore the source of the increased circulation estrogen, the extragonadal aromatization as well as the synthesis of androgen in the adrenal cortex of the ovariectomized rats was evaluated. METHODS: Female rats were divided into twelve groups: 1 month after ovariectomy (OVX1M), OVX2M, OVX3M, OVX4M, OVX5M, OVX6M; intact 1 month (INT1M), INT2M, INT3M, INT4M, INT5M, INT6M. The blood concentration of testosterone (T) was measured by radioimmunoassay.

Author(s): 
Zhao, Hong
Tian, Zhanzhuang
Hao, Junwei
Chen, Boying

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