Arsenites

Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

The burden of protein misfolding is believed to contribute to aging. However, the links between adaptations to conditions associated with protein misfolding and resistance to the time-dependent attrition of cellular function remain poorly understood. We report that worms lacking aip-1, a homologue of mammalian AIRAP (arsenic-inducible proteasomal 19S regulatory particle-associated protein), are not only impaired in their ability to resist exposure to arsenite but also exhibit shortened lifespan and hypersensitivity to misfolding-prone proteins under normal laboratory conditions.

Author(s): 
Yun, Chi
Stanhill, Ariel
Yang, Yun
Zhang, Yuhong
Haynes, Cole M.
Xu, Chong-Feng
Neubert, Thomas A.
Mor, Adam
Philips, Mark R.
Ron, David
Publication Title: 
Aging Cell

Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. In the nematode C. elegans, low-dose arsenite promotes resistance against thermal and chemical stressors and extends lifespan of this metazoan, whereas higher concentrations reduce longevity. While arsenite causes a transient increase in reactive oxygen species (ROS) levels in C.

Author(s): 
Schmeisser, Sebastian
Schmeisser, Kathrin
Weimer, Sandra
Groth, Marco
Priebe, Steffen
Fazius, Eugen
Kuhlow, Doreen
Pick, Denis
Einax, J¸rgen W.
Guthke, Reinhard
Platzer, Matthias
Zarse, Kim
Ristow, Michael
Publication Title: 
Aging Cell

Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. In the nematode C. elegans, low-dose arsenite promotes resistance against thermal and chemical stressors and extends lifespan of this metazoan, whereas higher concentrations reduce longevity. While arsenite causes a transient increase in reactive oxygen species (ROS) levels in C.

Author(s): 
Schmeisser, Sebastian
Schmeisser, Kathrin
Weimer, Sandra
Groth, Marco
Priebe, Steffen
Fazius, Eugen
Kuhlow, Doreen
Pick, Denis
Einax, J¸rgen W.
Guthke, Reinhard
Platzer, Matthias
Zarse, Kim
Ristow, Michael
Publication Title: 
Journal of Toxicology and Environmental Health. Part A

The use of dietary adsorbents to reduce arsenic (As) exposure is innovative. Ferrihydrite successfully sorbs arsenite and asenate over a wide range of pH conditions and the As-ferrihydrite complexes are stable in gastrointestinal (GIT) models.

Author(s): 
Taylor, John F.
Robinson, Abraham
Mitchell, Nicole J.
Marroquin-Cardona, Alicia
Johnson, Natalie
Elmore, Sarah E.
Romoser, Amelia A.
Phillips, Timothy D.
Publication Title: 
PloS One

In the Sahel, most malaria deaths occur among children 1-4 years old during a short transmission season. A trial of seasonal intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) and a single dose of artesunate (AS) showed an 86% reduction in the incidence of malaria in Senegal but this may not be the optimum regimen. We compared this regimen with three alternatives.

Author(s): 
Sokhna, Cheikh
Cissé, Badara
Bâ, El Hadj
Milligan, Paul
Hallett, Rachel
Sutherland, Colin
Gaye, Oumar
Boulanger, Denis
Simondon, Kirsten
Simondon, François
Targett, Geoffrey
Lines, Jo
Greenwood, Brian
Trape, Jean-François
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: Whether ultra-highly diluted homeopathic remedies can affect living systems is questionable. Therefore, this study sees value in the analysis of whether homeopathically diluted glucose 30C has any effect on Escherichia coli exposed to arsenite stress. METHODS: E.

Author(s): 
Khuda-Bukhsh, Anisur Rahman
De, Arnab
Das, Durba
Dutta, Suman
Boujedaini, Naoual
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To examine if potentiated homeopathic drug Arsenicum Album 30C (Ars Alb 30C) can reduce sodium arsenite-induced toxicity in Escherichia coli. METHODS: E. coli were exposed to low arsenite insult after they grew up to log phase in standard Luria-Bertani medium. E. coli were treated with 1 or 2 mmol/L sodium arsenite alone (control), or Ars Alb 30C was added to the medium of a subset of sodium arsenite-treated bacteria (drug-treated), or homeopathically agitated alcohol was added to the medium containing a subset of sodium arsenite-treated bacteria (placebo-treated).

Author(s): 
De, Arnab
Das, Durba
Dutta, Suman
Chakraborty, Debrup
Boujedaini, Naoual
Khuda-Bukhsh, Anisur Rahman
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