Asian Continental Ancestry Group

Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Okinawa, an isolated island prefecture of Japan, has among the highest prevalence of exceptionally long-lived individuals in the world; therefore, we hypothesized that, within this population, genes that confer a familial survival advantage might have clustered. We analyzed the pedigrees of 348 centenarian families with 1142 siblings and compared sibling survival with that of the 1890 Okinawan general population cohort. Both male and female centenarian siblings experienced approximately half the mortality of their birth cohort-matched counterparts.

Willcox, Bradley J.
Willcox, D. Craig
He, Qimei
Curb, J. David
Suzuki, Makoto
Publication Title: 
Lipids in Health and Disease

BACKGROUND: The -493G/T polymorphism in the microsomal triglyceride transfer protein (MTP) gene is associated with lower serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and longevity in several populations, but the results are inconsistent in different racial/ethnic groups. The current study was to investigate the plausible association of MTP -493G/T polymorphism with serum lipid levels and longevity in Zhuang long-lived families residing in Bama area, a famous home of longevity in Guangxi, China.

Pan, Shang-Ling
Luo, Xiao-Qiu
Lu, Ze-Ping
Lu, Shao-Hua
Luo, Huan
Liu, Cheng-Wu
Hu, Cai-You
Yang, Ming
Du, Li-Li
Song, Zhen
Pang, Guo-Fang
Wu, Hua-Yu
Huang, Jin-Bo
Peng, Jun-hua
Yin, Rui-Xing
Publication Title: 
Aging Cell

?-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of ?-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the ?-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity survey. The Han Chinese population in this study consisted of 963 long-lived and 1028 geography-matched young individuals.

Zhao, Ling
Yang, Fan
Xu, Ke
Cao, Huiqing
Zheng, Gu-Yan
Zhang, Yan
Li, Jianxin
Cui, Hanbin
Chen, Xiaomin
Zhu, Zhiming
He, Hongbo
Mo, Xianming
Kennedy, Brian K.
Suh, Yousin
Zeng, Yi
Tian, Xiao-Li
Publication Title: 
Journal of Human Genetics

The purpose of the present study was to identify mitochondrial DNA (mtDNA) polymorphisms and rare variants that associate with elite Japanese athletic status. Subjects comprised 185 elite Japanese athletes who had represented Japan at international competitions (that is, 100 endurance/middle-power athletes: EMA; 85 sprint/power athletes: SPA) and 672 Japanese controls (CON). The entire mtDNA sequences (16?569?bp) were analyzed by direct sequencing. Nucleotide variants were detected at 1488 sites in the 857 entire mtDNA sequences.

Mikami, Eri
Fuku, Noriyuki
Kong, Qing-Peng
Takahashi, Hideyuki
Ohiwa, Nao
Murakami, Haruka
Miyachi, Motohiko
Higuchi, Mitsuru
Tanaka, Masashi
Pitsiladis, Yannis P.
Kawahara, Takashi
Publication Title: 
The British Journal of Nutrition

Dietary patterns, which reflect the complexity of food preference, lifestyle and socio-economic status, may play a major role in health and longevity. Understanding dietary patterns and their correlates is important to the research of diet and health relationships. In the Shanghai Men's Health Study (SMHS) a total of 61,582 men aged 40-74 were recruited between 2002 and 2006. Their food intake over the previous year was collected using a validated FFQ. Study participants (75.6%) reported little or no change in meat and vegetable intake in the 5 years prior to recruitment.

Cai, Hui
Zheng, Wei
Xiang, Yong-Bing
Xu, Wang Hong
Yang, Gong
Li, Honglan
Shu, Xiao Ou
Publication Title: 
Hypertension Research: Official Journal of the Japanese Society of Hypertension

Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis and is considered a risk factor for cardiovascular disease. The role of diet in the etiology of MetS is poorly understood, especially among Asian subjects. This cross-sectional study assessed the relationship between diet and the number of MetS components among Japanese men (n=609) and women (n=631). Mean (s.d.) age and body mass index were 57.1 (12.1) years and 22.8 (2.8) kg m(-2) for men and 55.5 (12.0) years and 22.0 (3.0) kg m(-2) for women, respectively.

Otsuka, Rei
Imai, Tomoko
Kato, Yuki
Ando, Fujiko
Shimokata, Hiroshi
Publication Title: 
Nihon Aruk?ru Yakubutsu Igakkai Zasshi = Japanese Journal of Alcohol Studies & Drug Dependence
Sato, Nobuhiro
Publication Title: 
The Journal of Nutrition

Dietary guidelines generally recommend avoiding a high-fat diet. However, the relationship between fat subtypes and mortality remains unclear especially in a population with a relatively low intake of fat. We aimed to prospectively examine the relationship between dietary fat intake and all-cause and cause-specific mortality in a Japanese community. In 1992, a total of 28,356 residents of Takayama, Japan, without cancer, stroke, or coronary heart disease, responded to a validated 169-item FFQ. We identified 4616 deaths during a 16-y follow-up.

Nagata, Chisato
Nakamura, Kozue
Wada, Keiko
Oba, Shino
Tsuji, Michiko
Tamai, Yuya
Kawachi, Toshiaki
Publication Title: 

Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are the predominant long-chain polyunsaturated fatty acids (PUFA) among membrane phospholipids in the mammalian brain and neural tissues. This cross-sectional study examined age effects on serum eicosapentaenoic acid (EPA), DHA, and ARA compositions assessed with reference to dietary intakes among 1,014 Japanese men and 1,028 Japanese women aged 40-79 years. Venous blood was collected early in the morning after at least 12-h fasting. Serum fatty acid (FA) compositions were expressed as molar percentages of the total FA (mol% of total).

Otsuka, Rei
Kato, Yuki
Imai, Tomoko
Ando, Fujiko
Shimokata, Hiroshi
Publication Title: 
PloS One

The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis) is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction. HSCR is attributed to a failure of migration of the enteric ganglion precursors along the developing gut. RET is a key regulator of the development of the enteric nervous system (ENS) and the major HSCR-causing gene. Yet the reduced penetrance of RET DNA HSCR-associated variants together with the phenotypic variability suggest the involvement of additional genes in the disease.

Tang, Clara Sze-Man
Tang, Wai-Kiu
So, Man-Ting
Miao, Xiao-Ping
Leung, Brian Man-Chun
Yip, Benjamin Hon-Kei
Leon, Thomas Yuk-Yu
Ngan, Elly Sau-Wai
Lui, Vincent Chi-Hang
Chen, Yan
Chan, Ivy Hau-Yee
Chung, Patrick Ho-Yu
Liu, Xue-Lai
Wu, Xuan-Zhao
Wong, Kenneth Kak-Yuen
Sham, Pak-Chung
Cherny, Stacey S.
Tam, Paul Kwong-Hang
Garcia-BarcelÛ, Maria-MercË


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