Asian Continental Ancestry Group

Publication Title: 
BMJ open

OBJECTIVES: Optimal control of type 2 diabetes is challenging in many patient populations including in South Asian patients. We systematically reviewed studies on the effect of diabetes management interventions targeted at South Asian patients with type 2 diabetes on glycaemic control. DESIGN: Systematic review of MEDLINE, EMBASE and CINAHL databases for randomised controlled trials (RCTs) and pre-post-test studies (January 1990 to February 2014). Studies were stratified by where interventions were conducted (South Asia vs Western countries).

Author(s): 
Bhurji, N.
Javer, J.
Gasevic, D.
Khan, N. A.
Publication Title: 
BMJ open

OBJECTIVES: Optimal control of type 2 diabetes is challenging in many patient populations including in South Asian patients. We systematically reviewed studies on the effect of diabetes management interventions targeted at South Asian patients with type 2 diabetes on glycaemic control. DESIGN: Systematic review of MEDLINE, EMBASE and CINAHL databases for randomised controlled trials (RCTs) and pre-post-test studies (January 1990 to February 2014). Studies were stratified by where interventions were conducted (South Asia vs Western countries).

Author(s): 
Bhurji, N.
Javer, J.
Gasevic, D.
Khan, N. A.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: Despite a growing body of literature on complementary and alternative medicine, there is still limited information on the use of Ayurveda in the United States. Because Ayurveda is one of the world's major traditional medical systems, knowledge of its use is important. In particular, information on utilization by Asian Indians living in the United States is needed due to increased immigration from India and related regions. Recent reports of heavy metal contamination of some imported Ayurveda products underscore this need.

Author(s): 
Satow, Yumi E.
Kumar, Praveena D.
Burke, Adam
Inciardi, John F.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Okinawa, an isolated island prefecture of Japan, has among the highest prevalence of exceptionally long-lived individuals in the world; therefore, we hypothesized that, within this population, genes that confer a familial survival advantage might have clustered. We analyzed the pedigrees of 348 centenarian families with 1142 siblings and compared sibling survival with that of the 1890 Okinawan general population cohort. Both male and female centenarian siblings experienced approximately half the mortality of their birth cohort-matched counterparts.

Author(s): 
Willcox, Bradley J.
Willcox, D. Craig
He, Qimei
Curb, J. David
Suzuki, Makoto
Publication Title: 
Lipids in Health and Disease

BACKGROUND: The -493G/T polymorphism in the microsomal triglyceride transfer protein (MTP) gene is associated with lower serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and longevity in several populations, but the results are inconsistent in different racial/ethnic groups. The current study was to investigate the plausible association of MTP -493G/T polymorphism with serum lipid levels and longevity in Zhuang long-lived families residing in Bama area, a famous home of longevity in Guangxi, China.

Author(s): 
Pan, Shang-Ling
Luo, Xiao-Qiu
Lu, Ze-Ping
Lu, Shao-Hua
Luo, Huan
Liu, Cheng-Wu
Hu, Cai-You
Yang, Ming
Du, Li-Li
Song, Zhen
Pang, Guo-Fang
Wu, Hua-Yu
Huang, Jin-Bo
Peng, Jun-hua
Yin, Rui-Xing
Publication Title: 
Aging Cell

?-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of ?-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the ?-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity survey. The Han Chinese population in this study consisted of 963 long-lived and 1028 geography-matched young individuals.

Author(s): 
Zhao, Ling
Yang, Fan
Xu, Ke
Cao, Huiqing
Zheng, Gu-Yan
Zhang, Yan
Li, Jianxin
Cui, Hanbin
Chen, Xiaomin
Zhu, Zhiming
He, Hongbo
Mo, Xianming
Kennedy, Brian K.
Suh, Yousin
Zeng, Yi
Tian, Xiao-Li
Publication Title: 
Journal of Human Genetics

The purpose of the present study was to identify mitochondrial DNA (mtDNA) polymorphisms and rare variants that associate with elite Japanese athletic status. Subjects comprised 185 elite Japanese athletes who had represented Japan at international competitions (that is, 100 endurance/middle-power athletes: EMA; 85 sprint/power athletes: SPA) and 672 Japanese controls (CON). The entire mtDNA sequences (16?569?bp) were analyzed by direct sequencing. Nucleotide variants were detected at 1488 sites in the 857 entire mtDNA sequences.

Author(s): 
Mikami, Eri
Fuku, Noriyuki
Kong, Qing-Peng
Takahashi, Hideyuki
Ohiwa, Nao
Murakami, Haruka
Miyachi, Motohiko
Higuchi, Mitsuru
Tanaka, Masashi
Pitsiladis, Yannis P.
Kawahara, Takashi
Publication Title: 
The British Journal of Nutrition

Dietary patterns, which reflect the complexity of food preference, lifestyle and socio-economic status, may play a major role in health and longevity. Understanding dietary patterns and their correlates is important to the research of diet and health relationships. In the Shanghai Men's Health Study (SMHS) a total of 61,582 men aged 40-74 were recruited between 2002 and 2006. Their food intake over the previous year was collected using a validated FFQ. Study participants (75.6%) reported little or no change in meat and vegetable intake in the 5 years prior to recruitment.

Author(s): 
Cai, Hui
Zheng, Wei
Xiang, Yong-Bing
Xu, Wang Hong
Yang, Gong
Li, Honglan
Shu, Xiao Ou
Publication Title: 
Hypertension Research: Official Journal of the Japanese Society of Hypertension

Metabolic syndrome (MetS) represents a cluster of risk factors for atherosclerosis and is considered a risk factor for cardiovascular disease. The role of diet in the etiology of MetS is poorly understood, especially among Asian subjects. This cross-sectional study assessed the relationship between diet and the number of MetS components among Japanese men (n=609) and women (n=631). Mean (s.d.) age and body mass index were 57.1 (12.1) years and 22.8 (2.8) kg m(-2) for men and 55.5 (12.0) years and 22.0 (3.0) kg m(-2) for women, respectively.

Author(s): 
Otsuka, Rei
Imai, Tomoko
Kato, Yuki
Ando, Fujiko
Shimokata, Hiroshi
Publication Title: 
Nihon Aruk?ru Yakubutsu Igakkai Zasshi = Japanese Journal of Alcohol Studies & Drug Dependence
Author(s): 
Sato, Nobuhiro

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