Publication Title: 
Women's Health (London, England)

Vasomotor symptoms and vaginal atrophy are both common menopausal symptoms. Hormone therapy is currently the only FDA-approved treatment for hot flashes. Current recommendations are to use the lowest dose of hormone therapy for the shortest period that will allow treatment goals to be met. Although the reanalysis of the WHI in 2007 by Roussow et al. provided evidence of coronary heart safety for users of hormone therapy under the age of 60 years and within 10 years of the onset of menopause, not all women desire or are candidates for hormone therapy.

Pinkerton, JoAnn V.
Stovall, Dale W.
Kightlinger, Rebecca S.
Publication Title: 
Journal of Health, Population, and Nutrition

In developed countries, vitamin B12 (cobalamin) deficiency usually occurs in children, exclusively breastfed ones whose mothers are vegetarian, causing low body stores of vitamin B12. The haematologic manifestation of vitamin B12 deficiency is pernicious anaemia. It is a megaloblastic anaemia with high mean corpuscular volume and typical morphological features, such as hyperlobulation of the nuclei of the granulocytes. In advanced cases, neutropaenia and thrombocytopaenia can occur, simulating aplastic anaemia or leukaemia.

Kocaoglu, Celebi
Akin, Fatih
Caksen, Hüseyin
Böke, Saltuk Buğra
Arslan, Sükrü
Aygün, Serhat
Publication Title: 
Journal of Neuropathology and Experimental Neurology

A large fraction of hereditary demyelinating neuropathies, classified as Charcot-Marie-Tooth disease type 1A, is associated with misexpression of peripheral myelin protein 22. In this study, we characterized morphologic and biochemical changes that occur with diseaseprogression in neuromuscular tissue of Trembler-J mice, a spontaneous rodent model of Charcot-Marie-Tooth disease type 1A. Using age-matched, 2- and 10-month-old, wild-type and Trembler-J mice, we observed neuromuscular deficits that progress from distal to proximal regions.

Nicks, Jessica Renee
Lee, Sooyeon
Kostamo, Kathryne Ann
Harris, Andrew Benford
Sookdeo, Amanda M.
Notterpek, Lucia
Publication Title: 
Science (New York, N.Y.)

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths.

Colman, Ricki J.
Anderson, Rozalyn M.
Johnson, Sterling C.
Kastman, Erik K.
Kosmatka, Kristopher J.
Beasley, T. Mark
Allison, David B.
Cruzen, Christina
Simmons, Heather A.
Kemnitz, Joseph W.
Weindruch, Richard
Publication Title: 
Journal of Anatomy

Changes in body weight due to changes in food intake are reflected by corresponding changes in the cardiac phenotype. Despite a growing body of literature on cardiac hypertrophy associated with obesity, little is known on the atrophic remodelling of the heart associated with calorie restriction. We hypothesized that, besides the cardiomyocyte compartment, capillaries and nerve fibres are involved in the atrophic process. C57Bl6 mice were kept on normal diet (control group) or at a calorie-restricted diet for 3 or 7 days (n = 5 each).

Gruber, Carina
Nink, Nadine
Nikam, Sandeep
Magdowski, Gerd
Kripp, Gerhard
Voswinckel, Robert
Mühlfeld, Christian
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

Caloric restriction (CR) is a dietary regimen known to promote lifespan by slowing down the occurrence of age-dependent diseases. The greatest risk factor for neurodegeneration in the brain is age, from which follows that CR might also attenuate the progressive loss of neurons that is often associated with impaired cognitive capacities. In this study, we used a transgenic mouse model that allows for a temporally and spatially controlled onset of neurodegeneration to test the potentially beneficial effects of CR.

Gräff, Johannes
Kahn, Martin
Samiei, Alireza
Gao, Jun
Ota, Kristie T.
Rei, Damien
Tsai, Li-Huei
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: The purpose of this study is to examine the inter- and intraexaminer reliability of determining the prevalence of vertebral artery hypoplasia on magnetic resonance imaging (MRI) as well as the reliability of assigning a severity grading of mild, moderate, or marked hypoplasia. METHODS: Two chiropractic radiologists independently evaluated the MR images of 131 adult patients retrospectively for visual vertebral artery hypoplasia. Severity of hypoplastic was graded. The side of hypoplasia and sex of the patient were recorded. The process was repeated after 1 month.

Peterson, Cynthia
Phillips, Lee
Linden, Ashleah
Hsu, William
Publication Title: 
Biological & Pharmaceutical Bulletin

The aim of this study is to investigate whether or not You Gui Wan (YGW), a classical herbal formula in Traditional Chinese Medicine (TCM), has an impact on rat uterine and vaginal atrophic processes induced by ovariectomy (OVX). Thirty-four OVX Sprague-Dawley (SD) rats were randomly divided into three sets, and orally administrated with YGW decoction, saline or estrogen for 11 weeks, respectively. Histomorphological changes of the uterus and vagina, and serum estradiol levels were then compared. Results showed that OVX caused a dramatic atrophy of the uterus and vagina in the rats.

Hu, Xiang
Wang, Jin
Yin, Qiao-Zhi
Lu, Hua
Yie, Shang-Mian


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