AU Rich Elements

Publication Title: 
Molecular and Cellular Biology

The AU-rich elements (AREs) encoded within many mRNA 3' untranslated regions (3'UTRs) are targets for factors that control transcript longevity and translational efficiency. Hsp70, best known as a protein chaperone with well-defined peptide-refolding properties, is known to interact with ARE-like RNA substrates in vitro. Here, we show that cofactor-free preparations of Hsp70 form direct, high-affinity complexes with ARE substrates based on specific recognition of U-rich sequences by both the ATP- and peptide-binding domains.

Author(s): 
Kishor, Aparna
Tandukar, Bishal
Ly, Yann V.
Toth, Eric A.
Suarez, Yvelisse
Brewer, Gary
Wilson, Gerald M.
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