Publication Title: 

BACKGROUND: Automatic control of depth of hypnosis using the Bispectral Index (BIS) can help to reduce phases of inadequate control. Automated BIS control with propofol or isoflurane administration via an infusion system has recently been described, a comparable study with isoflurane administration via a vaporizer had not been conducted yet. Our hypothesis was that our new model based closed-loop control system can safely be applied clinically and maintains the BIS within a defined target range better than manual control.

Locher, Stephan
Stadler, Konrad S.
Boehlen, Thomas
Bouillon, Thomas
Leibundgut, Daniel
Schumacher, Peter M.
Wymann, Rolf
Zbinden, Alex M.
Publication Title: 
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie

PURPOSE: The purpose of this randomized control trial was to determine the performance of a novel rule-based adaptive closed-loop system for propofol administration using the bispectral index (BIS(R)) and to compare the system's performance with manual administration. The effectiveness of the closed-loop system to maintain BIS close to a target of 45 was determined and compared with manual administration.

Hemmerling, Thomas M.
Charabati, Samer
Zaouter, Cedrick
Minardi, Carmelo
Mathieu, Pierre A.
Publication Title: 
Journal of Clinical Monitoring and Computing

To control the three components of general anesthesia (hypnosis, analgesia, and neuromuscular blockade), an automated closed-loop, anesthesia-drug delivery system (McSleepy) was developed. Bispectral index was used as the control variable for hypnosis, the analgoscore for analgesia, and phonomyography for neuromuscular blockade. McSleepy can be used to control the induction, maintenance and emergence from general anesthesia.

Wehbe, Mohamad
Arbeid, Erik
Cyr, Shantale
Mathieu, Pierre A.
Taddei, Riccardo
Morse, Joshua
Hemmerling, Thomas M.
Publication Title: 
Antimicrobial Agents and Chemotherapy

A simple, nonisotopic, semiautomated bioassay for the measurement of antimalarial drug levels in plasma or serum based on the quantitation of histidine-rich protein II in malaria culture is presented. The assay requires only small sample volumes and was found to be highly sensitive and reproducible. The results closely paralleled those obtained with isotopic bioassays (R = 0.988, P < 0.001) and high-performance liquid chromatography-electrochemical detection (R = 0.978, P < 0.001).

Noedl, Harald
Teja-Isavadharm, Paktiya
Miller, Robert Scott
Publication Title: 
PloS One

Placental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis. To facilitate the discovery of antimalarial drugs targeting the cytoadherence process of Plasmodium-infected erythrocytes in the placenta microvasculature, we have developed an automated image-based assay for high-throughput screening for potent cytoadherence inhibitors in vitro.

Ku, Min-Je
Dossin, Fernando de M.
Hansen, Michael A. E.
Genovesio, Auguste
Ayong, Lawrence
Freitas-Junior, Lucio H.
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