Azadirachta

Publication Title: 
Canadian Journal of Microbiology

Endophytic fungi represent an interesting group of microorganisms associated with the healthy tissues of terrestrial plants. They represent a large reservoir of genetic diversity. Fungal endophytes were isolated from the inner bark segments of ethnopharmaceutically important medicinal tree species, namely Terminalia arjuna, Crataeva magna, Azadirachta indica, Holarrhena antidysenterica, Terminalia chebula, and Butea monosperma (11 individual trees), growing in different regions of southern India. Forty-eight fungal species were recovered from 2200 bark segments.

Author(s): 
Tejesvi, Mysore V.
Mahesh, Basavanna
Nalini, Monnanda S.
Prakash, Harishchandra S.
Kini, Kukkundoor R.
Subbiah, Ven
Shetty, Hunthrike S.
Publication Title: 
Phytotherapy research: PTR

Eleven decoctions, obtained from indian plants widely used in ayurvedic medicine, have been investigated as a possible source of molecules exhibiting biological activity on the interaction between DNA and NF-kB, a transcription factor involved in the expression of proinflammatory genes. Cystic fibrosis (CF) cell line stimulated by TNF-? has been used as inflammatory cellular model to determinate interleukin-8 (IL-8), one of the most relevant pro-inflammatory mediator in CF regulated by the NF-kB.

Author(s): 
Guerrini, Alessandra
Mancini, Irene
Maietti, Silvia
Rossi, Damiano
Poli, Ferruccio
Sacchetti, Gianni
Gambari, Roberto
Borgatti, Monica
Publication Title: 
Pakistan journal of biological sciences: PJBS

Neem leaf dust and a commercial formulation of neem were tested on adult Bactrocera cucurbitae (Coquillett) and Bactrocera dorsalis (Hendel) to determine their effects on the longevity, fecundity and ovarian development. Different combinations of neem leaf dust and a commercial formulation of a neem compound incorporated with sugar solution and adult rearing diets were tested. The Laboratory tests showed that ingestion of neem can significantly reduced the longevity and fertility of both the fly species.

Author(s): 
Khan, Mahfuza
Aftab Hossain, M.
Saidul Islam, M.
Publication Title: 
Malaria Journal

BACKGROUND: The wide use of gametocytocidal artemisinin-based combination therapy (ACT) lead to a reduction of Plasmodium falciparum transmission in several African endemic settings. An increased impact on malaria burden may be achieved through the development of improved transmission-blocking formulations, including molecules complementing the gametocytocidal effects of artemisinin derivatives and/or acting on Plasmodium stages developing in the vector.

Author(s): 
Lucantoni, Leonardo
Yerbanga, Rakiswendé S.
Lupidi, Giulio
Pasqualini, Luciano
Esposito, Fulvio
Habluetzel, Annette
Publication Title: 
Biological & Pharmaceutical Bulletin

In India, Azadirachta indica is typically known as 'neem tree' and its leaves has long been used in the ayurvedic medical tradition as a treatment for diabetes mellitus. In-depth chromatographic investigation on chloroform extract resulted in identification of one new tetranortriterpenoid. Structural elucidation was established on the basis of spectral data as 24,25,26,27-tetranor-apotirucalla-(apoeupha)-1α-senecioyloxy-3α,7α-dihydroxy-14,20,22-trien-21,23-epoxy named by us as meliacinolin (1).

Author(s): 
Perez-Gutierrez, Rosa Martha
Damian-Guzman, Monica
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Azadirachta indica, a plant used widely in Ayurveda, has been reported to have anti-inflammatory, immunomodulatory and adaptogenic properties. The present study evaluates its hepatoprotective role. Fresh juice of tender leaves of Azadirachta indica (200 mg/kg body wt. p.o.) inhibited paracetamol (2 g/kg body wt. p.o.)-induced lipid peroxidation and prevented depletion of sulfhydryl groups in liver cells. There was an increase in serum marker enzymes of hepatic damage (aspartate transaminase, alanine transaminase and alkaline phosphatase) after paracetamol administration.

Author(s): 
Yanpallewar, S. U.
Sen, S.
Tapas, S.
Kumar, Mohan
Raju, S. S.
Acharya, S. B.
Publication Title: 
The Medical Journal of Malaysia

Neem, Azadirachta indica, is a plant from the family Meliaceae, known as "Pokok Semambu" in Malay community. It has been extensively used in India as traditional Ayurvedic and folklore minedicine for the treatment of various diseases. This study aimed to determine the distribution of selenium in the liver of rats during hepatocarcinogenesis when neem aqueous extract and dietary selenium was supplemented.

Author(s): 
Hanachi, P.
Loh, L. N.
Fauziah, O.
Rafiuz, Z. H.
Tee, S. T.
Lye, C. W.
Lam, T. P.
Publication Title: 
Current Medicinal Chemistry. Anti-Cancer Agents

Azadirachta indica, commonly known as neem, has attracted worldwide prominence in recent years, owing to its wide range of medicinal properties. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a cynosure of modern medicine. Neem elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex. More than 140 compounds have been isolated from different parts of neem.

Author(s): 
Subapriya, R.
Nagini, S.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Azadirachta indica A. Juss, popularly known as neem, has been extensively used in Ayurvedic medicine by Indian population for over 2000 years. It is used traditionally for the healing of various diseases. Natural products and their derivatives provide an excellent source for new anti-viral drugs. AIM OF THE STUDY: The present study aims at evaluating the activity of two polysaccharides (P1 and P2) isolated from the leaves of Azadirachta indica and their chemical sulfated derivatives (P1S and P2S) against poliovirus type 1 (PV-1).

Author(s): 
Faccin-Galhardi, Ligia Carla
Yamamoto, Kristie Aimi
Ray, Sayani
Ray, Bimalendu
Carvalho Linhares, Rosa Elisa
Nozawa, Carlos
Publication Title: 
Biological & Pharmaceutical Bulletin

In India, Azadirachta indica is typically known as 'neem tree' and its leaves has long been used in the ayurvedic medical tradition as a treatment for diabetes mellitus. In-depth chromatographic investigation on chloroform extract resulted in identification of one new tetranortriterpenoid. Structural elucidation was established on the basis of spectral data as 24,25,26,27-tetranor-apotirucalla-(apoeupha)-1α-senecioyloxy-3α,7α-dihydroxy-14,20,22-trien-21,23-epoxy named by us as meliacinolin (1).

Author(s): 
Perez-Gutierrez, Rosa Martha
Damian-Guzman, Monica

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