Bacopa

Publication Title: 
Nutrition Journal

BACKGROUND: One of the major challenges associated with our ageing population is the increasing incidence of age-associated cognitive decline, which has significant implications for an individual's ability to lead a productive and fulfilling life. In pure economic terms the costs of ageing reflects decreased productivity and engagement with the workforce. The maintenance of brain health underpinning intact cognition is a key factor to maintaining a positive, engaged, and productive lifestyle.

Author(s): 
Stough, Con K.
Pase, Matthew P.
Cropley, Vanessa
Myers, Stephen
Nolidin, Karen
King, Rebecca
Camfield, David
Wesnes, Keith
Pipingas, Andrew
Croft, Kevin
Chang, Dennis
Scholey, Andrew B.
Publication Title: 
Nutrients

?yurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. ?yurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics.

Author(s): 
Singh, Hemant K.
Publication Title: 
Clinics (São Paulo, Brazil)

OBJECTIVE: In the ancient Indian system of medicine, Ayurveda, Bacopa monniera is classified as Medhya rasayana, which includes medicinal plants that rejuvenate intellect and memory. Here, we investigated the effect of a standardized extract of Bacopa monniera on the dendritic morphology of neurons in the basolateral amygdala, a region that is concerned with learning and memory. METHODS: The present study was conducted on 2½-month-old Wistar rats. The rats were divided into 2-, 4- and 6-week treatment groups.

Author(s): 
Vollala, Venkata Ramana
Upadhya, Subramanya
Nayak, Satheesha
Publication Title: 
Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

OBJECTIVE: Bacopa monniera (BM), a traditional Ayurvedic medicine has been used in treatment for a number of disorders, particularly those involving anxiety, intellect and poor memory. The current study examined the effects of standardized extract of Bacopa monniera on the dendritic morphology in adult rats of hippocampal CA3 neurons, one of the regions concerned with learning and memory. MATERIALS AND METHODS: Adult Wistar (2.5-month-old) rats were designated into 2-, 4- and 6-week treatment groups.

Author(s): 
Vollala, Venkata Ramana
Upadhya, Subramanya
Nayak, Satheesha
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND: Studies on alternative medicines for generalized anxiety disorder (GAD) are few. Manasamitra Vataka (an Ayurveda preparation) is explored for its efficacy in patients with GAD with comorbid generalized social phobia. MATERIALS AND METHODS: Seventy-two (72) patients with GAD with comorbid social phobia meeting DSM IV TR criteria, and who were between the ages of 20 and 55 of either sex, participated in the study. They were randomly divided into three treatment groups: Group 1 (n=24) and Group II (n=24) received Manasamitra Vataka tablets (100 mg twice daily for 30 days).

Author(s): 
Tubaki, Basavaraj R.
Chandrashekar, Channapatna R.
Sudhakar, Deverakonda
Prabha, Talakad N. Sathya
Lavekar, Gandhidas S.
Kutty, Bindu M.
Publication Title: 
Nutrients

Āyurveda, the science (ved) of life (ayu), owing its origin to Veda, the oldest recorded wisdom of human civilization written in 3500 BCE, contains extensive knowledge of various diseases and their therapeutic approaches. It essentially relied on nature and the immune system of an individual, and therapeutic interventions were introduced only to augment the immune system. Āyurveda had eight specialties, including psycho-neuroscience (a combination of psychology, clinical psychology and psychiatry) and a unique promotive therapy encompassing nutrition, rejuvenation and geriatrics.

Author(s): 
Singh, Hemant K.
Publication Title: 
Rejuvenation Research

This review synthesizes behavioral research with neuromolecular mechanisms putatively involved with the low-toxicity cognitive enhancing action of Bacopa monnieri (BM), a medicinal Ayurvedic herb. BM is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer. Numerous animal and in vitro studies have been conducted, with many evidencing potential medicinal properties. Several randomized, double-blind, placebo-controlled trials have substantiated BM's nootropic utility in humans.

Author(s): 
Aguiar, Sebastian
Borowski, Thomas
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

Bacopa monniera (EBm), an Indian aquatic herb, has been used in traditional Ayurvedic medicine for centuries for indications related to memory and inflammation. More recently specific extracts of EBm have emerged that have been subjected to rigorous in vitro, animal and now human clinical trials. In this paper we discuss some of these studies with special reference to mechanisms and efficacy of a special extract of Bacopa (CDRI08). Studies using this extract indicate that CDRI08 has several modes of action on the human brain.

Author(s): 
Stough, Con
Scholey, Andrew
Cropley, Vanessa
Wesnes, Keith
Zangara, Andrea
Pase, Matthew
Savage, Karen
Nolidin, Karen
Lomas, Justine
Downey, Luke
Publication Title: 
PloS One

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently available as over the counter herbal remedy for memory enhancement in children and adults. However, the consumption of herbal drugs has been reported to alter the expression of drug metabolizing enzymes and membrane transporters.

Author(s): 
Singh, Rajbir
Panduri, Jagadeesh
Kumar, Devendra
Kumar, Deepak
Chandsana, Hardik
Ramakrishna, Rachumallu
Bhatta, Rabi Sankar
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Bacopa monniera Wettst. (syn. Herpestis monniera L.; Scrophulariaceae) is a commonly used Ayurvedic drug for mental disorders. The standardized extract was reported earlier to have significant anti-oxidant effect, anxiolytic activity and improve memory retention in Alzheimer's disease. Presently, the standardized methanolic extract of Bacopa monniera (bacoside A - 38.0+/-0.9) was investigated for potential antidepressant activity in rodent models of depression. The effect was compared with the standard antidepressant drug imipramine (15 mg/kg, ip).

Author(s): 
Sairam, K.
Dorababu, M.
Goel, R. K.
Bhattacharya, S. K.

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