In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.
The physical dependence liability of guanabenz, a hypotensive agent with central noradrenergic alpha 2-agonistic activity, was investigated. 1) Guanabenz showed a potent analgesic effect nearly equipotent to morphine by the modified Haffner's method, and repeated p.o. treatment resulted in the development of tolerance to the effect. 2) In the combined treatment of guanabenz with morphine or hexobarbital, it potentiated morphine analgesia and prolonged hexobarbital hypnosis in a dose dependent manner.
Archives Internationales De Pharmacodynamie Et De Thérapie
Metamizol (sodium N-(1,5-dimethyl-3-oxo-2-phenylpyrazolin-4-yl)-N-methylamino-methylsulphonate; Dipyrone) a non-narcotic analgesic was tested for hypnotic potentiating effect. Metamizol potentiated the hypnosis induced by pentobarbital, barbital and chloral hydrate. This effect was dose-dependent and was inversely proportional to the duration of the analgesic pretreatment. An augmented hypothermia and competition at drug metabolizing sites seem to be the mechanisms involved in the observed effect.