Behavioral Symptoms

Publication Title: 
Clinical Interventions in Aging

Many patients with Alzheimer's disease will develop agitation at later stages of the disease, which constitutes one of the most challenging and distressing aspects of dementia. Recently, nonpharmacological therapies have become increasingly popular and have been proven to be effective in managing the behavioral symptoms (including agitation) that are common in the middle or later stages of dementia. These therapies seem to be a good alternative to pharmacological treatment to avoid unpleasant side effects.

Author(s): 
Millán-Calenti, José Carlos
Lorenzo-López, Laura
Alonso-Búa, Begoña
de Labra, Carmen
González-Abraldes, Isabel
Maseda, Ana
Publication Title: 
Free Radical Biology & Medicine

Oxidative stress is a prominent feature of Huntington's disease (HD) due to mitochondrial dysfunction and the ensuing overproduction of reactive oxygen species (ROS). This phenomenon ultimately contributes to cognitive and motor impairment, as well as brain pathology, especially in the striatum. Targeting the transcription of the endogenous antioxidant machinery could be a promising therapeutic approach. The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway is an important pathway involved in antioxidant and anti-inflammatory responses.

Author(s): 
Stack, Cliona
Ho, Daniel
Wille, Elizabeth
Calingasan, Noel Y.
Williams, Charlotte
Liby, Karen
Sporn, Michael
Dumont, Magali
Beal, M. Flint
Publication Title: 
Archives of Suicide Research: Official Journal of the International Academy for Suicide Research

A number of recent studies have shown epigenetic alterations associated with suicidal behavior. These epigenetic mechanisms, which alter gene expression via alternative mechanisms to the coding DNA sequence, result from environmental effects acting on the genome.

Author(s): 
LabontÈ, Benoit
Turecki, Gustavo
Publication Title: 
Neurobiology of Aging

Epidemiological evidence implies a role for chronic stress and stress-related disorders in the etiopathogenesis of sporadic Alzheimer's disease (AD). Although chronic stress exposure during various stages of life has been shown to exacerbate AD-related cognitive deficits and neuropathology in AD mouse models, the role of stress exposure during the prenatal period on AD development and progression remained to be investigated.

Author(s): 
Sierksma, Annerieke S. R.
Prickaerts, Jos
Chouliaras, Leonidas
Rostamian, Somayeh
Delbroek, Lore
Rutten, Bart P. F.
Steinbusch, Harry W. M.
van den Hove, Daniel L. A.
Publication Title: 
The American Journal of Clinical Nutrition

BACKGROUND: Fetal alcohol spectrum disorders (FASDs) are conditions characterized by physical anomalies, neurodevelopmental abnormalities, and neurocognitive deficits, including intellectual, executive, and memory deficits. There are no specific biological treatments for FASDs, but rodent models have shown that prenatal or postnatal choline supplementation reduces cognitive and behavioral deficits. Potential mechanisms include phospholipid production for axonal growth and myelination, acetylcholine enhancement, and epigenetic effects.

Author(s): 
Wozniak, Jeffrey R.
Fuglestad, Anita J.
Eckerle, Judith K.
Fink, Birgit A.
Hoecker, Heather L.
Boys, Christopher J.
Radke, Joshua P.
Kroupina, Maria G.
Miller, Neely C.
Brearley, Ann M.
Zeisel, Steven H.
Georgieff, Michael K.
Publication Title: 
Journal of Clinical Psychology

OBJECTIVE: Research has linked adolescent romantic and sexual activities to depressive symptoms. The current study examines whether such activities are uniquely linked to depressive symptoms versus symptoms of other disorders (including anxiety, externalizing, and eating disorders), and whether co-occurring symptoms more precisely account for the association between depressive symptoms and romantic involvement. METHOD: Early adolescent girls (N = 83; mean age = 13.45) participated in baseline and 1-year follow up data collection.

Author(s): 
Starr, Lisa R.
Davila, Joanne
Stroud, Catherine B.
Clara Li, Po Ching
Yoneda, Athena
Hershenberg, Rachel
Ramsay Miller, Melissa
Publication Title: 
The Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry

No one who read Frieda Fromm-Reichmann's "Transference Problems in Schizophrenia" could reasonably think about persons with schizophrenia in the same way as before. Her writings made clear that schizophrenia is a human experience with meaning, meaning that is hard to uncover, but it only takes patience, kindness, a tolerance for not understanding as well as for the patient's desperate defenses, and a willingness to understand the human condition at its most painful and to take psychoanalytic ideas seriously when patients talk about them.

Author(s): 
Karon, Bertram P.
Publication Title: 
The Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry

No one who read Frieda Fromm-Reichmann's "Transference Problems in Schizophrenia" could reasonably think about persons with schizophrenia in the same way as before. Her writings made clear that schizophrenia is a human experience with meaning, meaning that is hard to uncover, but it only takes patience, kindness, a tolerance for not understanding as well as for the patient's desperate defenses, and a willingness to understand the human condition at its most painful and to take psychoanalytic ideas seriously when patients talk about them.

Author(s): 
Karon, Bertram P.
Publication Title: 
British Journal of Nursing (Mark Allen Publishing)

Management of dementia should focus on the maintenance of function and independence for the person with the disease. Non-pharmacological interventions to manage dementia include reality orientation, aromatherapy and validation therapy. Non-pharmacological ways of managing challenging behaviour are recommended in current guidance. Drug treatments, which may stabilize the symptoms of Alzheimer's disease or slow down further progression for a time, have been available in the United Kingdom since 1997 and may help some people with dementia.

Author(s): 
Ouldred, Emma
Bryant, Catherine
Publication Title: 
Geriatrics & Gerontology International
Author(s): 
Kimura, Takemi
Takamatsu, Junichi

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