Benzoates

Publication Title: 
Toxicology and Applied Pharmacology
Author(s): 
Lal, H.
Shah, H. C.
Publication Title: 
The Journal of Pharmacy and Pharmacology

Alcoholic liver disease (ALD) is one of the most common diseases in society. A large number of studies are in progress to identify natural substances that are effective in reducing the severity of ALD. 2-Hydroxy-4-methoxy benzoic acid (HMBA), the active principle of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant in India, is expected to significantly inhibit the development of liver injury in ethanol administration.

Author(s): 
Saravanan, Nadana
Rajasankar, Srinivasagam
Nalini, Namasivayam
Publication Title: 
The Journal of Pharmacy and Pharmacology

The aim of the present study was to determine the effect of 2-hydroxy 4-methoxy benzoic acid (HMBA), the active principle of Hemidesmus indicus, an indigenous Ayurvedic medicinal plant in India. We investigated the effect of HMBA on hyperlipidaemia induced by ethanol, exploring food intake, body weight, and hepatic and plasma lipids and lipoproteins. Male Wistar rats weighing 130-180 g were given ethanol (5 g kg(-1) p.o.) daily for 30 days. Subsequently, ethanol-fed rats were given HMBA intragastrically at a dose of 200 microg kg(-1) per day for 30 days.

Author(s): 
Saravanan, Nadana
Nalini, Namasivayam
Publication Title: 
Biological & Pharmaceutical Bulletin

Paeoniflorin (PF) is an active glucoside in Shaoyao (peony root), and is transformed into an antispasmodic metabolite, paeonimetabolin-I (PM-I), by intestinal bacteria in the gut after oral administration of Shaoyao or Shaoyao-Gancao-tang (SGT, Shakuyaku-Kanzo-To in Japanese). SGT is a pain-relieving traditional Chinese formulation (Kampo-medicine in Japanese) and is often used together with antibacterial synthetic drugs, such as amoxicillin and metronidazole (AMPC-MET), in peptic ulcer therapy.

Author(s): 
He, Ju-Xiu
Akao, Teruaki
Tani, Tadato
Publication Title: 
Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry

A method based on capillary electrophoresis with electrochemical detection has been developed for the separation and determination of paeoniflorin, sucrose, glucose, and fructose in traditional Chinese medicine, Radix Paeoniae Alba. The effects of several important factors, such as the concentration of NaOH, the separation voltage, the injection time, and the detection potential, were investigated to determine the optimum conditions. The detection electrode was a 300-microm diameter copper disc electrode at a working potential of +0.60 V (versus SCE).

Author(s): 
Chen, Gang
Zhang, Luyan
Yang, Pengyuan
Publication Title: 
Chemical & Pharmaceutical Bulletin

A monolithic osmotic pump tablet (MOPT) of Traditional Chinese Medicine Compound Recipe (TCMCR) was successfully prepared and active components of Jingzhiguanxin prescription which has been widely used in China and Japan was selected as model drug. Analysis methods of maker compound in vitro of danshensu, paeoniflorin and safflor yellow A were built, and different methods were compared by f2 factors. The results showed that there were fine correlation among them.

Author(s): 
Yang, Xing-Gang
Zhang, Guo-Hua
Li, Wei
Peng, Bo
Liu, Zhi-Dong
Pan, Wei-San
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Paeoniflorin (PF) is the principal component of Paeoniae radix prescribed in traditional Chinese medicine. The delayed neuroprotection induced by PF preconditioning and its underlying mechanisms were investigated in rat middle cerebral artery occlusion (MCAO) and reperfusion model. At a dosage of 20 or 40 mg/kg, PF preconditioning 48 h before MCAO followed by 24-h reperfusion significantly reduced the mortality and infarct volume and reversed the neurological deficits caused by ischemia.

Author(s): 
Chen, Dong-Mei
Xiao, Liang
Cai, Xin
Zeng, Rong
Zhu, Xing-Zu
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To simultaneously determine the contents and explore the pharmacokinetics of ferulic acid and paeoniflorin by high performance liquid chromatography (HPLC) after oral administration of Modified Xiao-yao Decoction (MXYD), a compound of traditional Chinese herbal medicine. METHODS: A total of 8 healthy men were enlisted in this study. The serum samples were preprocessed by immersion method.

Author(s): 
Li, Hui
Ren, Ping
Huang, Xi
Tang, Wen-Fu
Wei, Hong-qiang
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To explore the effects of Western medicine including Ca(2+) channel antagonist and angiotensin-receptor antagonist combined with Songling Xuemaikang Capsule (SXC), a compound traditional Chinese herbal medicine for calming liver and suppressing liver yang, on blood pressure indexes derived from 24-hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure. METHODS: Seventy patients with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group.

Author(s): 
Fu, Li
Mao, Zhen-Xing
Wang, Jing
Zhang, Jing
Zheng, Tai-Rong
Wang, Sheng-Lian
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To study the anti-inflammatory effects of the combinations of active components of Painong powder, a compound traditional Chinese herbal medicine, and the quantitative analysis of their interactions. METHODS: The mouse model of acute inflammation with increase of capillary permeability was induced by intraperitoneal injection of acetic acid. An orthogonal design with 2 levels (used and unused) was applied to assign the combinations groups of active ingredients including naringin and neohesperidin, peoniflorin, and platycodin.

Author(s): 
Chen, Jun-Chao
Li, Lu-Jin
Wen, Shi-Mei
He, Ying-Chun
Liu, Hong-Xia
Zheng, Qing-Shan

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