Benzoxepins

Publication Title: 
Planta Medica

HPLC-SPE-NMR analysis of a crude extract of fermentation broth of cultured PESTALOTIOPSIS VIRGATULA isolate TC-320 from TERMINALIA CHEBULA Retz. (Combretaceae) disclosed the presence of a simple but unprecedented low-molecular-weight metabolite, 9-hydroxybenzo[ C]oxepin-3[1 H]-one, subsequently isolated by a targeted purification procedure.

Author(s): 
Kesting, Julie R.
Staerk, Dan
Tejesvi, Mysore V.
Kini, Kukkundoor R.
Prakash, Harishchandra S.
Jaroszewski, Jerzy W.
Publication Title: 
Journal of Natural Products

The endophytic fungus Pestalotiopsis virgatula, derived from the plant Terminalia chebula and previously found to produce a large excess of a single metabolite when grown in the minimal M1D medium, was induced to produce a variety of unusual metabolites by growing in potato dextrose broth medium. Analysis of the fermentation medium extract was performed using an HPLC-PDA-MS-SPE-NMR hyphenated system, which led to the identification of a total of eight metabolites (1-8), six of which are new.

Author(s): 
Kesting, Julie R.
Olsen, Lars
Staerk, Dan
Tejesvi, Mysore V.
Kini, Kukkundoor R.
Prakash, Harishchandra S.
Jaroszewski, Jerzy W.
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