beta Catenin

Publication Title: 
PloS One

Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways might be offset by increased cancer risk on account of their propensity to boost cell survival. The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals.

Author(s): 
Firestein, Ron
Blander, Gil
Michan, Shaday
Oberdoerffer, Philipp
Ogino, Shuji
Campbell, Jennifer
Bhimavarapu, Anupama
Luikenhuis, Sandra
de Cabo, Rafael
Fuchs, Charles
Hahn, William C.
Guarente, Leonard P.
Sinclair, David A.
Publication Title: 
Molecular and Cellular Biology

Telomerase canonically maintains telomeres, but recent reports have suggested that the core protein mammalian telomerase reverse transcriptase (TERT) component, together with the chromatin remodeling factor BRG1 and ?-catenin, may also bind to and promote expression of Wnt target genes. However, this proposed noncanonical role of TERT in Wnt signaling has been controversial. Here, we investigated the effects of human TERT (hTERT) on Wnt signaling in human breast cancer lines and HeLa cells.

Author(s): 
Listerman, Imke
Gazzaniga, Francesca S.
Blackburn, Elizabeth H.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: z-Guggulsterone (z-Gug) and Gugulipid (GL) have been used to treat a variety of ailments. We now report their anti-cancer effect and mechanism against human breast cancer. METHODS: Using the human estrogen receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cells as well as the normal human mammary epithelial cell line (HMEC), we evaluated the anti-breast-cancer efficacy and apoptosis inducing activity of GL. We determined the cellular and molecular mechanism of GL-inhibited breast cancer cell growth.

Author(s): 
Jiang, Guoqin
Xiao, Xiao
Zeng, Yan
Nagabhushanam, Kalyanam
Majeed, Muhammed
Xiao, Dong
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: z-Guggulsterone (z-Gug) and Gugulipid (GL) have been used to treat a variety of ailments. We now report their anti-cancer effect and mechanism against human breast cancer. METHODS: Using the human estrogen receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cells as well as the normal human mammary epithelial cell line (HMEC), we evaluated the anti-breast-cancer efficacy and apoptosis inducing activity of GL. We determined the cellular and molecular mechanism of GL-inhibited breast cancer cell growth.

Author(s): 
Jiang, Guoqin
Xiao, Xiao
Zeng, Yan
Nagabhushanam, Kalyanam
Majeed, Muhammed
Xiao, Dong
Publication Title: 
The Journal of Biological Chemistry

Osteoblast lineage-specific differentiation of mesenchymal stem cells is a well regulated but poorly understood process. Both bone morphogenetic proteins (BMPs) and Wnt signaling are implicated in regulating osteoblast differentiation and bone formation. Here we analyzed the expression profiles of mesenchymal stem cells stimulated with Wnt3A and osteogenic BMPs, and we identified connective tissue growth factor (CTGF) as a potential target of Wnt and BMP signaling.

Author(s): 
Luo, Qing
Kang, Quan
Si, Weike
Jiang, Wei
Park, Jong Kyung
Peng, Ying
Li, Xinmin
Luu, Hue H.
Luo, Jeffrey
Montag, Anthony G.
Haydon, Rex C.
He, Tong-Chuan
Publication Title: 
Cancer Research

Deregulation of beta-catenin signaling is an important event in the genesis of several human malignancies including prostate cancer. We investigated the effects of apigenin, a naturally occurring plant flavone, on prostate carcinogenesis in TRAMP mice and further elucidated its mechanism of action. Oral intake of apigenin by gavage at doses of 20 and 50 microg/mouse/d, 6 days per week for 20 weeks, significantly decreased tumor volumes of the prostate as well as completely abolished distant-site metastases to lymph nodes, lungs, and liver in TRAMP mice.

Author(s): 
Shukla, Sanjeev
Maclennan, Gregory T.
Flask, Chris A.
Fu, Pingfu
Mishra, Anil
Resnick, Martin I.
Gupta, Sanjay
Publication Title: 
Neoplasia (New York, N.Y.)

Chemopreventive effects and associated mechanisms of grape seed extract (GSE) against intestinal/colon cancer development are largely unknown. Herein, we investigated GSE efficacy against intestinal tumorigenesis in APC(min/+) mice. Female APC(min/+) mice were fed control or 0.5% GSE (wt/wt) mixed AIN-76A diet for 6 weeks. At the end of the experiment, GSE feeding decreased the total number of intestinal polyps by 40%. The decrease in polyp formation in the small intestine was 42%, which was mostly in its middle (51%) and distal (49%) portions compared with the proximal one.

Author(s): 
Velmurugan, Balaiya
Singh, Rana P.
Kaul, Nidhi
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
Endocrinology

beta-Catenin/T-cell factor signaling (beta-CTS) plays multiple critical roles in carcinogenesis and is blocked by androgens in androgen receptor (AR)-responsive prostate cancer (PrCa) cells, primarily via AR sequestration of beta-catenin from T-cell factor. Dehydroepiandrosterone (DHEA), often used as an over-the-counter nutritional supplement, is metabolized to androgens and estrogens in humans. The efficacy and safety of unregulated use of DHEA are unclear.

Author(s): 
Liu, Xunxian
Arnold, Julia T.
Blackman, Marc R.
Publication Title: 
Molecular Carcinogenesis

Chemoprevention by dietary agents/supplements has emerged as a novel approach to control various malignancies, including colorectal cancer (CRC). This study assessed dietary grape seed extract (GSE) effectiveness in preventing azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated mechanisms in Fischer 344 rats. Six-week-old rats were injected with AOM, and fed control diet or the one supplemented with 0.25% or 0.5% (w/w) GSE in pre- and post-AOM or only post-AOM experimental protocols.

Author(s): 
Velmurugan, Balaiya
Singh, Rana P.
Agarwal, Rajesh
Agarwal, Chapla
Publication Title: 
Molecular Pharmacology

As one of the most common malignancies, colon cancer is initiated by abnormal activation of the Wnt/β-catenin pathway. Although the treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. We have found that bisbenzylisoquinoline alkaloid tetrandrine (TET) exhibits anticancer activity. TET is used as a calcium channel blocker to treat hypertensive and arrhythmic conditions in Chinese medicine. Here, we investigate the molecular basis underlying TET's anticancer activity.

Author(s): 
He, Bai-Cheng
Gao, Jian-Li
Zhang, Bing-Qiang
Luo, Qing
Shi, Qiong
Kim, Stephanie H.
Huang, Enyi
Gao, Yanhong
Yang, Ke
Wagner, Eric R.
Wang, Linyuan
Tang, Ni
Luo, Jinyong
Liu, Xing
Li, Mi
Bi, Yang
Shen, Jikun
Luther, Gaurav
Hu, Ning
Zhou, Qixin
Luu, Hue H.
Haydon, Rex C.
Zhao, Yingming
He, Tong-Chuan

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