Publication Title: 
Human Molecular Genetics

Niemann-Pick type C (NPC) disease, an autosomal recessive disorder caused primarily by loss-of-function mutations in NPC1 gene, is characterized neuropathologically by intracellular cholesterol accumulation, gliosis and neuronal loss in selected brain regions. Recent studies have shown that NPC disease exhibits intriguing parallels with Alzheimer's disease (AD), including the presence of tau-positive neurofibrillary tangles (NFTs) and ?-amyloid (A?)-related peptides in vulnerable brain regions. Since enhanced cholesterol level, which acts as a risk factor for AD, can increase A?

Maulik, Mahua
Ghoshal, Bibaswan
Kim, John
Wang, Yanlin
Yang, Jing
Westaway, David
Kar, Satyabrata
Publication Title: 
Chemical & Pharmaceutical Bulletin

The main objective of this research is to improve the dissolution rate of artemisinin (ART) by fabrication with ?-cyclodextrin (?-CD) as a hydrophilic carrier. Artemisinin nanoparticles and ART/?-CD complexes were successfully fabricated by means of evaporative precipitation of nanosuspension. Characterization of the samples was done by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and dissolution tester.

Kakran, Mitali
Sahoo, Nanda Gopal
Li, Lin
Judeh, Zaher
Publication Title: 
AAPS PharmSciTech

Artemisinin, a poorly water-soluble antimalarial drug, presents a low and erratic bioavailability upon oral administration. The aim of this work was to study an agglomerated powder dosage form for oral administration of artemisinin based on the artemisinin/?-cyclodextrin primary microparticles. These primary microparticles were prepared by spray-drying a water-methanol solution of artemisinin/?-cyclodextrin. ?-Cyclodextrin in spray-dried microparticles increased artemisinin water apparent solubility approximately sixfold.

Balducci, Anna Giulia
Magosso, Enrico
Colombo, Gaia
Sonvico, Fabio
Khan, Nurzalina Abdul Karim
Yuen, Kah Hay
Bettini, Ruggero
Colombo, Paolo
Rossi, Alessandra
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

The purpose of this study was to simultaneously improve the solubility and stability of dihydroartemisinin (DHA) in aqueous solutions by a ternary cyclodextrin system comprised of DHA, hydroxypropyl-?-cyclodextrin (HP-?-CD) and a third auxiliary substance. Solubility and phase solubility studies were carried out to evaluate the solubilizing efficiency of HP-?-CD in association with various auxiliary substances.

Wang, Dan
Li, Haiyan
Gu, Jingkai
Guo, Tao
Yang, Shuo
Guo, Zhen
Zhang, Xueju
Zhu, Weifeng
Zhang, Jiwen
Publication Title: 
The Journal of Biological Chemistry

Macrophage-specific Abca1 knock-out (Abca1(-)(M)(/-)(M)) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate immune response of macrophages. Plasma lipid and lipoprotein concentrations in chow-fed Abca1(-)(M)(/-)(M) and wild-type (WT) mice were indistinguishable.

Zhu, Xuewei
Lee, Ji-Young
Timmins, Jenelle M.
Brown, J. Mark
Boudyguina, Elena
Mulya, Anny
Gebre, Abraham K.
Willingham, Mark C.
Hiltbold, Elizabeth M.
Mishra, Nilamadhab
Maeda, Nobuyo
Parks, John S.
Publication Title: 
The Journal of Nutritional Biochemistry

Fish oil-enriched long chain n-3 polyunsaturated fatty acids disrupt the molecular organization of T-cell proteins in the immunological synapse. The impact of fish oil derived n-3 fatty acids on antigen-presenting cells, particularly at the animal level, is unknown. We previously demonstrated B-cells isolated from mice fed with fish oil-suppressed naïve CD4(+) T-cell activation.

Rockett, Benjamin Drew
Melton, Mark
Harris, Mitchel
Bridges, Lance C.
Shaikh, Saame Raza
Publication Title: 
Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University

OBJECTIVE: To study the factors affecting cyclodextrin (CD) inclusion of the volatile components in compound traditional Chinese medicines and evaluate the stability of the inclusion compound. METHODS: This study took Gengnian compound as an example to examine the factors affecting the inclusion process according to the inclusion compound utilization ratio. Orthogonal design method was employed optimize the parameters in the inclusion process. The moisture absorption rate of the beta-CD inclusion compound was determined in different humidity and Q10 was used to predict its.

Yi, Yan-kui
Chen, Zhi-liang
Publication Title: 
International Journal of Nanomedicine

Icariin is a bioactive herbal ingredient isolated from Herba epimedii, which has been widely used for the treatment of osteoporosis and male sexual dysfunction in traditional Chinese medicine. The major objective of this work is to investigate the different enhancing effects of β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the intestinal absorption of icariin, and to identify the molecular mechanisms of this action.

Zhang, Ye
Wang, Qiang-Song
Cui, Yuan-Lu
Meng, Fan-Cui
Lin, Ke-Ming
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