Biliary Tract

Publication Title: 
British Journal of Pharmacology

1. The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies. 2. In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 ml min(-1) in controls (n=8) to 6.0+/-1.0 ml min(-1) in MI (n=8; P<0.01). Clearance in control livers was similar to the perfusion flow rate, suggesting a high hepatic extraction ratio for DHA. 3.

Author(s): 
Batty, K. T.
Ilett, K. F.
Edwards, G.
Powell, S. M.
Maggs, J. L.
Park, B. K.
Davis, T. M.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Ezetimibe (EZE) lowers serum lipid levels by blocking cholesterol uptake in the intestine. Disposition of EZE and its pharmacologically active glucuronide metabolite (EZE-GLUC) to the intestine is dependent on hepatobiliary efflux. Previous studies suggested that hepatic transporter expression and function may be altered during nonalcoholic steatohepatitis (NASH). The purpose of the current study was to determine whether NASH-induced changes in the expression and function of hepatic transporters result in altered disposition of EZE and EZE-GLUC.

Author(s): 
Hardwick, Rhiannon N.
Fisher, Craig D.
Street, Stephanie M.
Canet, Mark J.
Cherrington, Nathan J.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

Echinacoside (ECH) is one of the major active phenylethanoid glycosides (PEGs) in famous traditional Chinese medicine, Herba Cistanches. Although it has various bioactivities, such as antioxidation, neuroprotection, and hepatoprotection, knowledge about its metabolic fate is scant.

Author(s): 
Jia, Cunqin
Shi, Haiming
Jin, Wei
Zhang, Ke
Jiang, Yong
Zhao, Mingbo
Tu, Pengfei
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