Biotechnology

Publication Title: 
Journal of Biotechnology

It has been widely reported that CHO cells undergo apoptosis in culture, despite supplementation of nutrients through fed-batch strategies. Improvement of cell viability in culture can effectively improve recombinant protein yield through extension of the culture's production lifespan, especially at high cell densities. Heat shock proteins (HSPs) have been reported to demonstrate anti-apoptotic effects against a wide range of physical and chemical stimuli through their ability to bind and act as antagonists to critical apoptotic molecules.

Author(s): 
Lee, Yih Yean
Wong, Kathy T. K.
Tan, Janice
Toh, Poh Choo
Mao, Yanying
Brusic, Vesna
Yap, Miranda G. S.
Publication Title: 
Science (New York, N.Y.)
Author(s): 
Couzin, Jennifer
Publication Title: 
The Keio Journal of Medicine

Rapid progress is being made in our ability to modify the aging process. Rather than serving as a period of debility and decreasing health, for many people, the later years of life are becoming a period of continued productivity, independence and good health. Progress is also being made in increasing average lifespan. The leading causes of death (cardiovascular disease, cancer, lung disease, diabetes) are the end result of decades-long processes. With current knowledge, it is possible to delay the onset of these diseases.

Author(s): 
Grossman, Terry
Publication Title: 
PLoS biology
Author(s): 
Blackburn, Elizabeth
Rowley, Janet
Publication Title: 
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics

Genome-wide association aims to comprehensively survey genetic variation for the purposes of disease and trait mapping. We provide a brief history of the development of genetic technology necessary to realize genome-wide association. From there we identify and review the publicly available resources for conducting such work including the molecular technologies, genomic databases, and analytic tools. Following on from the analytic tools, we highlight common analytic considerations, ranging from study design, quality control, and data cleaning to association analysis and replication.

Author(s): 
Neale, Benjamin M.
Purcell, Shaun
Publication Title: 
Journal of Agricultural & Environmental Ethics

Patents for genetic material in the industrialized North have expanded significantly over the past twenty years, playing a crucial role in the current configuration of the agricultural biotechnology industries, and raising significant ethical issues. Patents have been claimed for genes, gene sequences, engineered crop species, and the technical processes to engineer them. Most critics have addressed the human and ecosystem health implications of genetically engineered crops, but these broad patents raise economic issues as well.

Author(s): 
Warner, K. D.
Publication Title: 
The American journal of bioethics: AJOB

"Love hurts"-as the saying goes-and a certain amount of pain and difficulty in intimate relationships is unavoidable. Sometimes it may even be beneficial, since adversity can lead to personal growth, self-discovery, and a range of other components of a life well-lived. But other times, love can be downright dangerous. It may bind a spouse to her domestic abuser, draw an unscrupulous adult toward sexual involvement with a child, put someone under the insidious spell of a cult leader, and even inspire jealousy-fueled homicide. How might these perilous devotions be diminished?

Author(s): 
Earp, Brian D.
Wudarczyk, Olga A.
Sandberg, Anders
Savulescu, Julian
Publication Title: 
Developing World Bioethics

One effect of late capitalism--the commodification of practically everything--is to knock down the Chinese walls between the natural and productive realms, to use a Marxist framework. Women's labour in egg extraction and 'surrogate' motherhood might then be seen as what it is, labour which produces something of value. But this does not necessarily mean that women will benefit from the commodification of practically everything, in either North or South.

Author(s): 
Dickenson, Donna
Publication Title: 
Politics and the Life Sciences: The Journal of the Association for Politics and the Life Sciences

In a recent issue of Politics and the Life Sciences Mark Walker presented a compelling proposition for reducing evil in the world via an interdisciplinary program he calls the "Genetic Virtue Project" (GVP). As Walker explains, the purpose of the GVP is "to discover and enhance human ethics using biotechnology genetic correlates of virtuous behavior." PLS subsequently published several critiques of this proposal.

Author(s): 
Robison, Shea
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Despite considerable efforts by multiple governmental and nongovernmental organizations to increase access to artemisinin-based combination therapies (ACTs), these life-saving antimalarial drugs remain largely unaffordable to the most vulnerable populations. The cost of artemisinin derivatives, ACTs' crucial active ingredients, contributes significantly to the high price of these therapies.

Author(s): 
Hale, Victoria
Keasling, Jay D.
Renninger, Neil
Diagana, Thierry T.

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