Blood Chemical Analysis

Publication Title: 
Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion

The acupuncture-moxibustion serum has received wide attention as a new idea and method. Its application on researches in vivo and the treatment of disease not only has an important theory value, but also provides new ideas for overcoming the limitations of researches in vivo and some disease's treatment.

Author(s): 
He, Jing
Yu, Jian-chun
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet

BACKGROUND: Tri-sa-maw recipe is a botanical preparation comprised of equal proportions ofthe three herbalfruits, namely Terminalia chebula Retz., Tenninalia sp. and Terminalia bellirica Roxb. This recipe is used for antipyretic, expectorant, periodic maintenance, and relieving stomach tight. OBJECTIVE: To evaluate the acute and sub-chronic toxicities of Tri-sa-maw recipe extract in rats. MATERIAL AND METHOD: In the present study of acute toxicity, a single oral dose 5,000 mg/kg of Tri-sa-maw recipe extract was administered to rats.

Author(s): 
Nanna, Urarat
Jaijoy, Kanjana
Lertprasertsuke, Nirush
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Publication Title: 
Ideggyógyászati Szemle
Author(s): 
Koronkai, B.
Publication Title: 
British Medical Journal
Author(s): 
Black, S.
Friedman, M.
Publication Title: 
Malaria Journal

BACKGROUND: Artesunate plus sulphadoxine-pyrimethamine is one of the four artemisinin-based combination therapies currently recommended by WHO as first-line treatment for falciparum malaria. Sulphadoxine-pyrimethamine is also used for intermittent preventive treatment for malaria in pregnancy. Drug use patterns and drug pharmacokinetics are important factors impacting the spread of drug resistant parasites hence it is imperative to monitor the effect of pharmacokinetic variability on therapeutic efficacy.

Author(s): 
Gbotosho, Grace O.
Happi, Christian T.
Sijuade, Abayomi O.
Sowunmi, Akin
Oduola, Ayoade M. J.
Publication Title: 
European Journal of Clinical Pharmacology

PURPOSE: Dihydroartemisinin-piperaquine (DP) is a fixed-dose artemisinin-based combination treatment. Field pharmacokinetic studies would be simplified and facilitated by being able to use small volume capillary assays rather than venous blood. The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.

Author(s): 
Ashley, Elizabeth A.
Stepniewska, Kasia
Lindegardh, Niklas
Annerberg, Anna
Tarning, Joel
McGready, Rose
Phaiphun, Lucy
Singhasivanon, Pratap
White, Nicholas J.
Nosten, François
Publication Title: 
The Journal of Infectious Diseases

BACKGROUND: In 2008, Guinea-Bissau introduced artemether-lumefantrine for treatment of uncomplicated malaria. Previously, 3 times the standard dose of chloroquine, that was probably efficacious against Plasmodium falciparum with the resistance-associated chloroquine-resistance transporter (pfcrt) 76T allele, was routinely used. The present study compared the efficacy and tolerability of a double standard dose of chloroquine with the efficacy and tolerability of artemether-lumefantrine.

Author(s): 
Ursing, Johan
Kofoed, Poul-Erik
Rodrigues, Amabelia
Blessborn, Daniel
Thoft-Nielsen, Rikke
Björkman, Anders
Rombo, Lars
Publication Title: 
Malaria Journal

BACKGROUND: Sulphadoxine-pyrimethamine, in combination with artesunate or amodiaquine, is recommended for the treatment of uncomplicated malaria and is being evaluated for intermittent preventive treatment. Yet, limited data is available on pharmacokinetic interactions between these drugs. METHODS: In a randomized controlled trial, children aged 6-59 months with uncomplicated falciparum malaria, received either one dose of sulphadoxine-pyrimethamine alone (SP), one dose of SP plus three daily doses of amodiaquine (SP+AQ) or one dose of SP plus 3 daily doses of artesunate (SP+AS).

Author(s): 
Tekete, Mamadou M.
Toure, Sekou
Fredericks, Alfia
Beavogui, Abdoul H.
Sangare, Cheick P. O.
Evans, Alicia
Smith, Peter
Maiga, Hamma
Traore, Zoumana I.
Doumbo, Ogobara K.
Barnes, Karen I.
Djimde, Abdoulaye A.
Publication Title: 
Malaria Journal

BACKGROUND: Artesunate-amodiaquine (AS&AQ) is a widely used artemisinin combination therapy (ACT) for falciparum malaria. A comprehensive appreciation of its effects on haematology vs other anti-malarials is needed in view of potential safety liabilities. METHODS: Individual-patient data analysis conducted on a database from seven randomized controlled trials conducted in sub-Saharan African comparing AS&AQ to reference treatments in uncomplicated falciparum malaria patients of all ages.

Author(s): 
Zwang, Julien
Ndiaye, Jean-Louis
Djimde, Abdoulaye
Dorsey, Grant
Mårtensson, Andreas
Karema, Corine
Olliaro, Piero
Publication Title: 
Journal of Ethnopharmacology

Chronic ethanol ingestion in rats showed metabolic and physiological changes similar to alterations reported in human alcoholics. There was a lowering of blood glucose concentration, urea and plasma proteins and elevated concentrations of serum gamma-glutamyl transpeptidase. Administration of SKV, an Ayurvedic formula produced by fermentation of cane sugar with raisins and 12 herbal ingredients brought down voluntary ethanol ingestion in the rats and increased food intake.

Author(s): 
Shanmugasundaram, E. R.
Shanmugasundaram, K. R.

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