Body Mass Index

Publication Title: 
The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi

BACKGROUND/AIMS: The prevalence of colonic diverticulosis in Korea is increasing in conjunction with the adoption of western dietary pattern, extension of lifespan, and advances in diagnostic modalities. The clinical characteristics of colonic diverticulosis seem to be gradually becoming similar to those of Western societies. Therefore, factors associated with the clinical characteristics of colonic diverticulosis in Korea were investigated.

Author(s): 
Kim, Sun Young
Kim, You Sun
Kim, Hyun Tae
Kwon, Sun Ok
Oh, Myoung Ki
Cha, In Hye
Ok, Kyeong Sam
Kwak, Cheol Hun
Kim, Jin Nam
Moon, Jeong Seop
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Families of centenarians have high levels of plasma high-density lipoprotein (HDL) cholesterol, which may have neurological as well as cardiovascular protective effects during aging. Because plasma HDL level declines progressively with aging, we examined whether centenarians with higher plasma HDL levels have better cognitive function.

Author(s): 
Atzmon, Gil
Gabriely, Ilan
Greiner, William
Davidson, Deborah
Schechter, Clyde
Barzilai, Nir
Publication Title: 
Clinical Cardiology

BACKGROUND: Asian Indian women have a higher rate of coronary artery disease (CAD) than do other ethnic groups, despite similar conventional risk factors and lipid profiles. Smaller high-density lipoprotein cholesterol (HDL-C) particle size is associated with reduced cardiac protection or even an increased risk of CAD. Exceptional longevity correlates better with larger HDL-C particle sizes.

Author(s): 
Bhalodkar, Narendra C.
Blum, Steve
Rana, Thakor
Kitchappa, Radha
Bhalodkar, Ami N.
Enas, Enas A.
Publication Title: 
Biogerontology

As the elderly population is increasing rapidly, there is a lot of scientific interest in clarifying the differential life-style, genetic, biochemical and molecular factors contributing to mortality or exceptional longevity. Within the framework of the ZINCAGE project, 249 old (60-85 years) and nonagenarian Greek subjects (>/=85 years old) were recruited and anthropometrical, blood and biochemical indices as well as blood pressure measurements were obtained.

Author(s): 
Kanoni, Stavroula
Dedoussis, George
Manios, Yannis
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Most survival studies of the elderly population have set their baselines for first examinations between 60 and 80 years. The rapidly increasing numbers of exceptionally old persons call for knowledge about determinants of exceptional survival. METHODS: The Swedish Centenarian Study followed 100 centenarians from the age of 100 to death of the entire cohort, by age 111 years. A biomedical, psychological, and social multivariate survival analysis was performed based on factors identified as important in earlier studies of older adults.

Author(s): 
Hagberg, Bo
Samuelsson, Gillis
Publication Title: 
Maturitas

The oldest old are among the fastest growing segment of the population and it is important to understand not only the influence of modifiable lifestyle factors such as diet and nutrition on the achievement of exceptional longevity but also the role, if any, of these factors on maintaining optimal cognitive, mental and physical health into advanced age.

Author(s): 
Hausman, Dorothy B.
Fischer, Joan G.
Johnson, Mary Ann
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess lifestyle factors including physical activity, smoking, alcohol consumption, and dietary habits in men and women with exceptional longevity. DESIGN: Retrospective cohort study. SETTING: A cohort of community-dwelling Ashkenazi Jewish individuals with exceptional longevity defined as survival and living independently at age 95 and older.

Author(s): 
Rajpathak, Swapnil N.
Liu, Yingheng
Ben-David, Orit
Reddy, Saritha
Atzmon, Gil
Crandall, Jill
Barzilai, Nir
Publication Title: 
BMC medical genetics

BACKGROUND: Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults. It is not known, however, whether or not telomere length is a highly conserved inheritable trait in this homogeneous cohort, where age-related diseases are highly prevalent. As such, the aim of this study was to address the inheritability of telomere length in Saudi families and the impact of cardiometabolic disease biomarkers on telomere length.

Author(s): 
Al-Attas, Omar S.
Al-Daghri, Nasser M.
Alokail, Majed S.
Alkharfy, Khalid M.
Alfadda, Assim A.
McTernan, Philip
Gibson, Greg C.
Sabico, Shaun B.
Chrousos, George P.
Publication Title: 
Aging Cell

Biomarkers of aging are essential to predict mortality and aging-related diseases. Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging because their associations with mortality generally diminish with age. How this pattern arises is, however, not understood. With meta-analysis we show that human leucocyte telomere length (TL) predicts mortality, and that this mortality association diminishes with age, as found for other biomarkers of aging.

Author(s): 
Boonekamp, Jelle J.
Simons, Mirre J. P.
Hemerik, Lia
Verhulst, Simon
Publication Title: 
Aging Cell

Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age-dependent LTL attrition during adulthood can substantially affect individuals' LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12 years apart on average by 1156 participants in four longitudinal studies.

Author(s): 
Benetos, Athanase
Kark, Jeremy D.
Susser, Ezra
Kimura, Masayuki
Sinnreich, Ronit
Chen, Wei
Steenstrup, Troels
Christensen, Kaare
Herbig, Utz
von Bornemann Hjelmborg, Jacob
Srinivasan, Sathanur R.
Berenson, Gerald S.
Labat, Carlos
Aviv, Abraham

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