Bone Density Conservation Agents

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Homeopathy is based on treatment by similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the secondary and paradoxical action of the organism as therapeutic response. This vital or homeostatic reaction of the organism can be scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after suspension of treatment.

Author(s): 
Teixeira, Marcus Zulian
Publication Title: 
European Cells & Materials

Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors.

Author(s): 
Mansell, Jason P.
Brown, Judith
Knapp, Jonathan G.
Faul, Charl F. J.
Blom, Ashley W.
Publication Title: 
Postgraduate Medicine

Vascular calcification (VC), commonly encountered in renal failure, diabetes, and aging, is associated with a large increase in the risk for cardiovascular events and mortality. Calcification of the arterial media and of heart valves clearly plays a mediating role in this regard, whereas it is less clear how calcification of plaque influences atherogenesis and risk for plaque rupture. Vascular calcification is an active process in which vascular smooth muscle cells (VSMCs) adopt an osteoblastic phenotype and deposit hydroxyapatite crystals; apoptosis of VSMCs also promotes this deposition.

Author(s): 
McCarty, Mark F.
DiNicolantonio, James J.
Publication Title: 
Molecular cancer research: MCR

Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now well recognized that osteoclasts are responsible for the osteolysis observed in bone metastases of the tumor.

Author(s): 
Reuter, Simone
Prasad, Sahdeo
Phromnoi, Kanokkarn
Kannappan, Ramaswamy
Yadav, Vivek R.
Aggarwal, Bharat B.
Publication Title: 
Molecular cancer research: MCR

Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now well recognized that osteoclasts are responsible for the osteolysis observed in bone metastases of the tumor.

Author(s): 
Reuter, Simone
Prasad, Sahdeo
Phromnoi, Kanokkarn
Kannappan, Ramaswamy
Yadav, Vivek R.
Aggarwal, Bharat B.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Ancient Indian ayurvedic literature prescribes Tinospora cordifolia as a remedy to rheumatoid arthritis, inflammatory and allied diseases of musculo skeletal system. AIM: To investigate the effects of the alcoholic extract of Tinospora cordifolia (TC) on the proliferation, differentiation and mineralization of bone like matrix on osteoblast model systems in vitro and hence its possible use as a potential anti-osteoporotic agent.

Author(s): 
Abiramasundari, G.
Sumalatha, K. R.
Sreepriya, M.
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

INTRODUCTION: Reduction of ovarian estrogen secretion at menopause increases net bone resorption and leads to bone loss. Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods.

Author(s): 
Weaver, C. M.
Martin, B. R.
Jackson, G. S.
McCabe, G. P.
Nolan, J. R.
McCabe, L. D.
Barnes, S.
Reinwald, S.
Boris, M. E.
Peacock, M.
Publication Title: 
Nutrition Research (New York, N.Y.)

Osteoporosis is a major health problem in both elderly women and men. Epidemiological evidence has shown an association between tea consumption and the prevention of age-related bone loss in elderly women and men. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures.

Author(s): 
Shen, Chwan-Li
Yeh, James K.
Cao, Jay J.
Wang, Jia-Sheng
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Studies suggest that green tea polyphenols (GTP) or alphacalcidol is promising agent for preventing bone loss. Findings that GTP supplementation plus alphacalcidol administration increased bone mass via a decrease of oxidative stress and inflammation suggest a significant role of GTP plus alphacalcidol in bone health of patients with chronic inflammation. INTRODUCTION: Studies have suggested that green tea polyphenols (GTP) or alphacalcidol are promising dietary supplements for preventing bone loss in women.

Author(s): 
Shen, C.-L.
Yeh, J. K.
Cao, J. J.
Tatum, O. L.
Dagda, R. Y.
Wang, J.-S.
Publication Title: 
PloS One

BACKGROUND: Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human bone health. This study examined the efficacy of GTP and TC on mitigation of oxidative damage in postmenopausal women with osteopenia. METHODS: A 6-month randomized and placebo-controlled clinical trial was conducted in 171 postmenopausal women with osteopenia, who were recruited from Lubbock County, Texas.

Author(s): 
Qian, Guoqing
Xue, Kathy
Tang, Lili
Wang, Franklin
Song, Xiao
Chyu, Ming-Chien
Pence, Barbara C.
Shen, Chwan-Li
Wang, Jia-Sheng

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